A5061675100- Tea Polyphenols and Effects
- Advanced Proteomics Techniques and Applications
- Potato Plant Research
- Metabolomics and Mass Spectrometry Studies
- Plant Molecular Biology Research
- Mass Spectrometry Techniques and Applications
- RNA and protein synthesis mechanisms
- Advanced oxidation water treatment
- Single-cell and spatial transcriptomics
- Analytical Chemistry and Chromatography
- Cancer, Hypoxia, and Metabolism
- Industrial Gas Emission Control
- Machine Learning in Bioinformatics
- Adipose Tissue and Metabolism
- Photosynthetic Processes and Mechanisms
- Bioinformatics and Genomic Networks
- Antimicrobial Peptides and Activities
- Cancer survivorship and care
- Light effects on plants
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
- Remote-Sensing Image Classification
- Geochemistry and Elemental Analysis
- Diet and metabolism studies
- Remote Sensing in Agriculture
University of Michigan–Ann Arbor
2024-2025
Nanjing University of Posts and Telecommunications
2022-2024
Anhui Agricultural University
2024
Bureau of Geology and Mineral Exploration and Development of Guizhou Province
2019-2023
BGI Group (China)
2015-2021
Chinese Academy of Inspection and Quarantine
2019-2021
Fujian Medical University
2021
China National GeneBank
2020
China Medical University
2020
Chinese Academy of Sciences
2015-2019
The FragPipe computational proteomics platform is gaining widespread popularity among the research community because of its fast processing speed and user-friendly graphical interface. Although produces well-formatted output tables that are ready for analysis, there still a need an easy-to-use downstream statistical analysis visualization tool. FragPipe-Analyst addresses this by providing R shiny web server to assist users in conducting analyses resulting quantitative data. It supports major...
ABSTRACT The FragPipe computational proteomics platform is gaining widespread popularity among the research community because of its fast processing speed and user-friendly graphical interface. Although produces well-formatted output tables that are ready for analysis, there still a need an easy-to-use downstream statistical analysis visualization tool. FragPipe-Analyst addresses this by providing R shiny web server to assist users in conducting analyses resulting quantitative data. It...
The interaction of naturally occurring minerals with H2O2 affects the remediation efficiency polluted sites in situ chemical oxidation (ISCO) treatments. However, interactions between vanadium(V) and have rarely been explored. In this study, decomposition by various vanadium-containing including V(III), V(IV), V(V) oxides was examined, mechanism hydroxyl radical (•OH) generation for contaminant degradation studied. Vanadium were found to catalyze efficiently produce •OH diethyl phthalate...
Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific metabolism remains largely unexplored. L-Theanine, an important quality component tea, is primarily synthesized in roots, from which it then transported to new shoots tea plant. In this study, we present RNA sequencing (scRNA-seq)-derived map for the plant root, enabled cell-type-specific analysis...
ABSTRACT Activation of innate immune signaling occurs during the progression immunometabolic diseases, including type 2 diabetes (T2D), yet impact on glucose homeostasis is controversial. Here, we report that E3 ubiquitin ligase TRAF6 integrates signals following diet-induced obesity to promote through induction mitophagy. Whereas was dispensable for and pancreatic β-cell function under basal conditions, pivotal insulin secretion, mitochondrial respiration, increases in mitophagy metabolic...
Chongming Island and its surrounding areas are highly significant coastal regions in China. However, the undergo continuous changes owing to various factors, such as sedimentation from Yangtze River, human activities, tidal movements. is part of River Delta, which one most economically developed Studying water body this area great importance for decision making resource conservation, management, ecological environmental protection. In study, we propose an improved ISUNet model by enhancing...
Abstract Liquid chromatography-mass spectrometry (LC-MS) based proteomics, particularly in the bottom-up approach, relies on digestion of proteins into peptides for subsequent separation and analysis. The most prevalent method identifying from data-dependent acquisition (DDA) mass data is database search. Traditional tools typically focus a single peptide per tandem spectrum (MS2), often neglecting frequent occurrence co-fragmentations leading to chimeric spectra. Here, we introduce...
Proteotoxicity is a contributor to the development of type 2 diabetes (T2D), but it unknown whether protein misfolding in T2D generalized or has special features. Here, we report robust accumulation misfolded proteins within mitochondria human pancreatic islets and elucidate its impact on β cell viability. Surprisingly, quantitative proteomics studies aggregates reveal that from donors with have signature more closely resembling mitochondrial rather than ER misfolding. The matrix protease...
β-Defensins (DEFBs) have a variety of functions. The majority these proteins were not identified in recent proteome survey. Neither protein detection nor the analysis transcriptomic data based on RNA-seq for three liver cancer cell lines any expression products. Extensive investigation into DEFB transcripts over 70 offered similar results. This fact naturally begs question—Why are genes scarcely expressed? After examining gene annotation and physicochemical properties its products, we...
Abstract An analytical method for the determination of six emerging derivatives or metabolites together with 25 common macrolides antibiotics in milk by ultra‐performance liquid chromatography quadrupole/electrostaticfield orbitrap mass spectrometry was established. The samples were purified optimized Quick, Easy, Cheap, Effective, Rugged, Safe methods. amounts primary‐secondary amine, C18, and sodium acetate adsorbent materials response surface to obtain best purification effect....
Database searches of MS/MS spectra are the main approach to peptide/protein identification in proteomics. Since most database search engines only utilize a small portion original signals for peptide detection, how improve quality is primary concern enhancement rate. A fundamental issue that some noise MS signals, informative or uninformative, have be filtered out prior searching. Herein, an integrative preprocessing algorithm was designed, termed pClean, which incorporates three modules...
Abstract Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific metabolism remains largely unexplored. L-theanine, an important quality component tea, is primarily synthesized in roots, from which it then transported to new shoots tea plant. In this study, we present RNA sequencing (scRNA-seq)-derived map for the plant root, enabled cell-type-specific...
Abstract Acute myeloid leukemia (AML) is a blood malignancy of poor prognosis with marked heterogeneity. To elucidate the underlying mechanisms that drive AML as part Clinical Proteomic Tumor Analysis Consortium (CPTAC) effort, we performed large scale comprehensive genomics, transcriptomics, proteomics including multiple post-translational modifications (phosphorylation, acetylation, and glycosylation), metabolomics, lipidomics characterization 173 treatment-naïve patients. Applying...
Abstract Acute myeloid leukemia (AML) is a blood malignancy of poor prognosis with marked heterogeneity. To elucidate the underlying mechanisms that drive AML as part Clinical Proteomic Tumor Analysis Consortium (CPTAC) effort, we performed comprehensive genomics, transcriptomics, proteomics including multiple post-translational modifications (phosphorylation, acetylation, and glycosylation), metabolomics, lipidomics characterization 173 treatment-naïve patients. Applying similarity network...
Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific metabolism remains largely unexplored. L-theanine, an important quality component tea, is primarily synthesized in roots, from which it then transported to new tea shoots. In this study, we present RNA sequencing (scRNA-seq)-derived map for the root, enabled cell-type-specific analysis glutamate...