A5016270380- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Genital Health and Disease
- Adolescent Sexual and Reproductive Health
- Bacterial Infections and Vaccines
- Blood groups and transfusion
- Sex work and related issues
- HIV, TB, and STIs Epidemiology
- Herpesvirus Infections and Treatments
- Reproductive Health and Contraception
- Female Genital Mutilation/Cutting Issues
- Otolaryngology and Infectious Diseases
- Respiratory viral infections research
- HIV Research and Treatment
- Diverticular Disease and Complications
- Child Abuse and Related Trauma
- Telemedicine and Telehealth Implementation
- Cutaneous Melanoma Detection and Management
- Social Media in Health Education
- Pelvic floor disorders treatments
- Sexual function and dysfunction studies
- Urinary and Genital Oncology Studies
- Food Allergy and Anaphylaxis Research
Melbourne Sexual Health Centre
2012-2024
Alfred Health
2013-2024
Sexual Health Clinic
2021
The University of Melbourne
2013-2016
Peter Doherty Institute
2016
Monash University
2016
Mahidol University
2016
Melbourne Health
2014
The Alfred Hospital
2011-2013
King Edward VIII Hospital
1995
Background. Our aim was to determine the efficacy of 1 g azithromycin and alternative antibiotic regimens in a prospective cohort Mycoplasma genitalium–infected participants, factors associated with failure. Methods. Consecutive eligible M. men women attending Melbourne Sexual Health Centre between July 2012 June 2013 were treated retested by polymerase chain reaction (PCR) on days 14 28. Cure defined as PCR negative day Cases failing moxifloxacin, those moxifloxacin pristinamycin. Pre-...
Abstract Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations parC (13.6%) gyrA (5%). ParC S83 changes were associated with failure. Combined macrolide/fluoroquinolone-resistance 8.6% of specimens, which recommended therapies would be ineffective.
The bacterial loads for gonococcal infections of the pharynx and rectum were determined among men with male sexual partners. median load rectal (18,960 copies/swab) was significantly higher than pharyngeal (2,100 copies/swab; P = 0.001). Bacterial symptomatic proctitis strikingly high (median, 278,000 copies/swab).
Syphilis continues to be a significant public health problem among HIV-positive men who have sex with (MSM) internationally. This study aimed determine whether the routine inclusion of syphilis serology every blood test performed as part HIV monitoring increases detection early asymptomatic MSM.We examined effect this intervention, implemented in January 2007, on MSM attending Melbourne Sexual Health Centre, Australia, and compared previous clinic policy annual screening.In 18 months before...
This before-and-after study measured the impact of a change in testing methods from culture to nucleic acid amplification (NAAT) on detection pharyngeal and rectal gonorrhea men who have sex with (MSM) sexual health service level, including effect subgroups anticipated higher rates gonorrhea.In March 2015, Melbourne Sexual Health Centre changed its laboratory method for gonococcal NAAT using Aptima Combo 2 GC tests. We compared proportion tests positive MSM 2014 those 2015.The by was double...
Mycoplasma genitalium is a cause of non-gonoccocal urethritis (NGU) in men and cervicitis pelvic inflammatory disease women. Recent international data also indicated that the first line treatment, 1 gram stat azithromycin therapy, for M. becoming less effective, with corresponding emergence macrolide resistant strains. Increasing failure rates has significant implications presumptive treatment NGU clinical guidelines. Assays able to predict resistance along detection will be useful enable...
We evaluated the impact of extended azithromycin (1.5g over 5 days) on selection macrolide resistance and microbiological cure in men with Mycoplasma genitalium urethritis during 2013-2015 compared this to cases treated 1g 2012-2013.Microbiological was determined for M. 1.5g using quantitative polymerase chain reaction specific DNA samples 14-100 days post-treatment. Pre- post-treatment mutations were detected by sequencing 23 S gene.There no difference proportions between 1g: 62/106 (58%;...
We compared the spectrum of pathogens responsible for infectious proctitis between HIV-positive and HIV-negative men who have sex with men. Only 32% herpes simplex virus (HSV)-associated had visible external anal ulceration.The etiology among is as follows: chlamydia (23.4% vs. 21.7%, P = 0.7), gonorrhea (13.4% 10.8%, 0.5), HSV-1 (14.2% 6.5%, 0.04), HSV-2 (22% 12.3%, 0.03), lymphogranuloma venereum (7.8% 0.7%, 0.004), multiple infections (17.7% 8.6%, 0.017). Thirty-two percent HSV ulceration.
<h3>Objective</h3> Previous studies have quantified bacterial loads of <i>Neisseria gonorrhoeae</i> in the pharynx and rectum men but not urethra. We load <i>N. with symptomatic asymptomatic urethral gonorrhoea infections. <h3>Methods</h3> Consecutive diagnosed by Aptima Combo 2 testing urine at Melbourne Sexual Health Centre between March July 2016 were eligible for study: purulent discharge no symptoms. The gonococcal both groups was measured swab using a standardised collection method...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Our study assessed the impact of a computer alert that reminded clinicians to test men who were at higher risk for syphilis on rate testing and diagnoses. The percentage high-risk have sex with tested increased from 77% 89% (P>.001), such asymptomatic 16% 53% (P=.001).
Authors examined persistence of Neisseria gonorrhoeae DNA following treatment for pharyngeal and rectal gonorrhea; N. persisted in 8% men 14 days after treatment. Persistence was associated with elevated ceftriaxone azithromycin MICs may also reflect reinfection.
This study aimed to identify enteric and sexually acquired rectal pathogens, other than chlamydia gonorrhea, associated with symptomatic proctitis in men who have sex (MSM).Anorectal swab samples were obtained from MSM presenting symptoms a clinical diagnosis of at the Melbourne Sexual Health Centre between January 2017 March 2019. Samples that tested positive for Neisseria gonorrhoeae Chlamydia trachomatis excluded. As comparison group, anorectal also not reporting November 2018 February...
Background Culture is insensitive for the detection of pharyngeal gonorrhoea but isolation pivotal to antimicrobial resistance surveillance. The aim this study was ascertain whether recommendations provided clinicians (doctors and nurses) on swabbing technique could improve rates determine which aspects are important optimal isolation. Methods This undertaken at Melbourne Sexual Health Centre, Australia. Detection among were compared before (June 2006–May 2009) after 2009–June 2012)...
ABSTRACT We examined the factors influencing gonorrhea detection at pharynx. One hundred men infected with Neisseria gonorrhoeae were swabbed from tonsils and posterior oropharynx. N. was reisolated oropharynx in 62% 52%, respectively ( P = 0.041). Culture positivity greater higher gonococcal DNA loads 0.001) < 0.001). can be cultured isolation rates where are higher.
The objective of this study was to determine the duration between onset symptoms early symptomatic syphilis and diagnosis among men who have sex with (MSM). A review cases primary secondary MSM presented Melbourne Sexual Health Centre January 2003 August 2007. mean age 123 included 37 years. Fifty-two percent (n = 64) 48% 59) syphilis. Twenty-five were HIV-positive. median rapid plasma reagin titre 1:32. Of 34 referred by general practitioners, referring practitioners did not consider in 10...
There are limited data from high-income countries on the performance of interferon-gamma release assays in screening for latent tuberculosis infection (LTBI). We analyzed routine application Quantiferon-TB Gold (QFT-G) assay to detect and predict active TB among HIV-infected patients Australia.A retrospective cohort study included all attending Melbourne Sexual Health Service between March 2003 February 2011 who were screened LTBI using QFT-G. Clinical multivariable models determine...
Abstract Background Current international guidelines on human immunodeficieny virus (HIV) Pre-Exposure Prophylaxis (PrEP) recommend serological screening for syphilis at routine 3-monthly PrEP appointments. The aim of our study was to describe the pattern clinical presentation among men who have sex with (MSM) taking PrEP. We were interested in whether is detected through scheduled3-monthly clinic appointments or primary secondary presented unscheduled interval visits. Methods This a...
Improving access to sexual health services is critical in light of rising sexually transmitted infections (STIs). We evaluated a hub-and-spoke model for improving three general practices Victoria, Australia. The primary outcome was the impact on HIV and STI (chlamydia, gonorrhoea, syphilis) testing. Segmented linear regression analysis conducted examine trends total HIV/STI tests pre- (from January 2019 June 2020) post-implementation July 2020 2021). feasibility acceptability integrating...
Syphilis infections continue to increase among men who have sex with (MSM) in many countries, rates often higher HIV-positive MSM. There is limited understanding of the risk and determinants syphilis transmission between men. We aimed examine concordance early infection male sexual partners clinical factors associated transmission.Men attending Melbourne Sexual Health Centre their partners, where at least one was diagnosed syphilis, were identified from linkage partner records March 2011...
High rates of syphilis have been reported among men who sex with (MSM) internationally. Guidelines recommend presumptive treatment sexual contacts individuals at the point care. The aim this study was to determine proportion were infected and factors predictive infection reporting contact a man syphilis.Contacts (cases) compared those uninfected (controls).This conducted main public sexually transmitted diseases clinic in Victoria, Australia.One hundred seventy-two MSM presenting as health...