A5091462670- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- HIV, Drug Use, Sexual Risk
- Blood groups and transfusion
- Microbial infections and disease research
- Adolescent Sexual and Reproductive Health
- Reproductive Health and Contraception
- Genital Health and Disease
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Sex and Gender in Healthcare
- Plant Virus Research Studies
- Cardiac Health and Mental Health
- Abdominal Trauma and Injuries
- Cardiac Fibrosis and Remodeling
- HIV, TB, and STIs Epidemiology
- Otolaryngology and Infectious Diseases
- Food Allergy and Anaphylaxis Research
- Electrolyte and hormonal disorders
- Medical Imaging Techniques and Applications
- Healthcare Quality and Management
Peter Doherty Institute
2016-2024
The University of Melbourne
1996-2024
Melbourne Sexual Health Centre
2016-2024
Alfred Health
2016-2024
National Public Health Laboratory
2022
Public Health Laboratory
2022
Melbourne Health
2021
Monash University
2016
This before-and-after study measured the impact of a change in testing methods from culture to nucleic acid amplification (NAAT) on detection pharyngeal and rectal gonorrhea men who have sex with (MSM) sexual health service level, including effect subgroups anticipated higher rates gonorrhea.In March 2015, Melbourne Sexual Health Centre changed its laboratory method for gonococcal NAAT using Aptima Combo 2 GC tests. We compared proportion tests positive MSM 2014 those 2015.The by was double...
The Victorian legislation requires sex workers to have quarterly screening for genital chlamydia and gonorrhoea, but oropharyngeal infection is not mandatory in Victoria, Australia. In 2017, gonorrhoea was added as part of the routine attending Melbourne Sexual Health Centre (MSHC). aim this study examine prevalence among female (FSW).We included females who (1) self-identified or were attended MSHC a work certificate (2) had tested any STI HIV, between March 2015 December 2017. syphilis,...
Objectives There are limited data on the prevalence of Mycoplasma genitalium (Mgen) coinfection with rectal chlamydia ( Chlamydia trachomatis (CT)) and gonorrhoea Neisseria gonorrhoeae (NG)) infections few studies examining pharyngeal Mgen in men who have sex (MSM). Using transcription-mediated amplification assay, this study aimed to determine proportion CT NG MSM coinfected Mgen, detected pharynx order inform clinical practice. Methods This was a cross-sectional conducted at Melbourne...
Empiric treatment of sexually transmitted infections can cause unnecessary antibiotic use. We determined if near-to-patient-testing (NPT) for
Objectives This prospective cohort study aimed to determine the natural history and incidence of oropharyngeal gonorrhoea chlamydia among a men who have sex with (MSM) over 12-week period, examine risk factors associated incident infections. Methods MSM either aged ≥18 years had diagnosis by nucleic acid amplification test (NAAT) in past 3 months or 18–35 were HIV-negative taking pre-exposure prophylaxis (PrEP) eligible for this study. Enrolled followed up 12 weeks. Oropharyngeal swabs...
Resistance-guided therapy (RGT) for gonorrhea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Aptima Combo 2 assay, ResistancePlus GC assay demonstrated 94.8% sensitivity and 100.0% specificity Neisseria gonorrhoeae detection. Of 379 concordant N. gonorrhoeae-positive samples, 86.8% were found to possess gyrA S91F mutation, which was highly predictive ciprofloxacin resistance stable across 3,144 publicly available genomes. Our work supports feasibility...
This study aimed to identify enteric and sexually acquired rectal pathogens, other than chlamydia gonorrhea, associated with symptomatic proctitis in men who have sex (MSM).Anorectal swab samples were obtained from MSM presenting symptoms a clinical diagnosis of at the Melbourne Sexual Health Centre between January 2017 March 2019. Samples that tested positive for Neisseria gonorrhoeae Chlamydia trachomatis excluded. As comparison group, anorectal also not reporting November 2018 February...
Background Lymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis serovars L1-L3. This study determined the positivity for LGV testing before and after introduction of universal positive rectal samples in men who have sex with (MSM). Methods From March 2015 to February 2018, MSM C. were not routinely tested at Melbourne Sexual Health Centre unless they had HIV or symptoms proctitis. all specimens over age 25 years, regardless was undertaken. defined as detection LGV-associated...
Improved knowledge of factors that promote outbreaks enteric pathogens among men who have sex with (MSM) could enable targeted public health interventions. We detected in 57 519 (11%) asymptomatic MSM, and we found pathogen detection was associated both oroanal (rimming) group sex.
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health problem. Traditionally, AMR surveillance programs for N. have focused mainly on laboratory data to describe the prevalence and trends of resistance. However, integrating individual-level risk factors (e.g., sexual orientation or international travel) with provides important insights into promoting spread resistant .
Screening for Chlamydia trachomatis and Neisseria gonorrhoeae at the pharyngeal, urogenital, anorectal sites is recommended men who have sex with (MSM). Combining three individual-site samples into a single pooled sample could result in significant cost savings, provided there no sensitivity reduction. The aim of this study was to examine detecting chlamydia gonorrhea asymptomatic MSM using nucleic acid amplification test.
Objective To help inform screening guidelines, we estimated the proportion of asymptomatic men who have sex with (MSM) oropharyngeal chlamydia. Study Design An audit MSM attending a sexual health service from March 2015 to April 2016 was conducted. They each had an swab that tested for Chlamydia trachomatis by transcription-mediated nucleic acid amplification. In addition, random sample 17 swabs initially positive confirmatory testing determine likelihood true positivity. Results We...
The aim of this study was to determine whether Chlamydia trachomatis could be detected in saliva and if infection is specific an anatomical site the oropharynx. Men who have sex with men (MSM) were diagnosed oropharyngeal chlamydia at Melbourne Sexual Health Centre 2017-2018 invited participate upon returning for treatment. Swabs tonsillar fossae posterior oropharynx a sample collected.
While ceftriaxone remains the first-line treatment for gonorrhoea, US CDC recommended cefixime as a second-line in 2021. We tested 1176 Neisseria gonorrhoeae isolates among clients attending Melbourne Sexual Health Centre 2021-2022. The prevalence of resistance was 6.3% (74/1176), azithromycin 4.9% (58/1176) and 0% (0/1176). Cefixime highest women (16.4%, 10/61), followed by men-who-have-sex-with-women (6.4%, 7/109), men-who-have-sex-with-men (5.8%, 57/982). cefixime-resistant N. exceeds...
The delay between onset of symptoms and coronary care unit admission is decisive in the outcome patients with acute myocardial infarction.To evaluate influence factors that affect infarction treatment.Multicenter case-control study conducted by 118 units Italy. median mean times cases controls were compared for decision time, home-to-hospital in-hospital several potential risk on was evaluated comparison admitted more than 6 hours after those within onset.Among 5301 infarction, 590 who came...
Introduction.Mycoplasma genitalium is a sexually transmitted pathogen with increasing resistance to first- and second-line antimicrobials. The 'near-patient test' ResistancePlus MG FleXible (SpeeDx) detects M. plus four macrolide mutations (MRMs), facilitating same-day patient follow up.Hypothesis/Gap Statement. This assay has not been assessed on freshly collected samples.Aim. Our goal was evaluate the performance of test against standard care open platform test.Methods. (analysed Cepheid...
Introduction. Mycoplasma genitalium is a sexually transmitted organism with high levels of resistance to the recommended first-line therapy, azithromycin. The ResistancePlus MG test concurrently detects M. genitalium, and presence macrolide-resistance mutations (MRM). European, UK Australian guidelines recommend diagnostic that reports MRM optimize treatment through resistance-guided therapy. Hence, for samples collected use on other platforms, reflex testing using would be...
Current clinical care for common bacterial STIs (Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG)) involves empiric antimicrobial therapy when clients are symptomatic, or if asymptomatic, waiting laboratory testing recall indicated. Near-to-patient (NPT) can improve pathogen-specific prescribing reduce unnecessary inappropriate antibiotic use in treating sexually transmitted infections (STI) by providing same-day delivery of results treatment. We compared...
Background In a previous study of men attending Melbourne Sexual Health Centre who had Neisseria gonorrhoeae detected by urine Aptima Combo 2 (AC2) testing, 11% were asymptomatic. This aimed to determine whether N. can be cultured from asymptomatic screening positive for nucleic acid amplification testing (NAAT) urine. Methods Between 1 July 2017 and 31 March 2019, all tested AC2 urethral symptoms reported or not. NAAT-positive recalled swab performed gonococcal culture using modified...
ABSTRACT Objectives Mathematical modelling and genomic analyses are powerful methods for investigating the transmission dynamics of Neisseria gonorrhoeae , however, often make implicit assumption that N. isolates at different anatomical sites within same individual strain. Methods In this study, two approaches were used to explore genetic diversity. First, we examined a collection stored, clinical sourced from multiple single individuals attending sexual health clinic in Melbourne 2011-2019....
Background: Current clinical care for common bacterial STIs (Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG)) involves empiric antimicrobial therapy when clients are symptomatic, or if asymptomatic, waiting laboratory testing recall indicated. Near-to-patient (NPT) can improve pathogen-specific prescribing reduce unnecessary inappropriate antibiotic use in treating sexually transmitted infections (STI) by providing same-day delivery of results...