A5074499581- Coenzyme Q10 studies and effects
- Biochemical Acid Research Studies
- Mitochondrial Function and Pathology
- Advanced battery technologies research
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Genomics and Chromatin Dynamics
- Anesthesia and Neurotoxicity Research
- ATP Synthase and ATPases Research
- Muscle metabolism and nutrition
- Neuroscience, Education and Cognitive Function
Universidad de Granada
2021-2024
Instituto de Investigación Biosanitaria de Granada
2022-2024
Centre for Biomedical Network Research on Rare Diseases
2015-2024
Instituto de Salud Carlos III
2015-2024
Universidad Pablo de Olavide
2016-2024
Centro Andaluz de Biología del Desarrollo
2016-2024
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2021-2023
Centro de Investigación Biomédica en Red
2019
Coenzyme Q (CoQ), a redox-active lipid, is comprised of quinone group and polyisoprenoid tail. It an electron carrier in the mitochondrial respiratory chain, cofactor other dehydrogenases, essential antioxidant. CoQ requires large set enzymes for its biosynthesis; mutations genes encoding these proteins cause primary deficiency, clinically genetically heterogeneous diseases. Patients with deficiency often respond to oral CoQ10 supplementation. Treatment however problematic because low...
The protein encoded by COQ7 is required for CoQ
The potential of pluripotent cells to respond developmental cues and trigger cell differentiation is enhanced during the G1 phase cycle, but molecular mechanisms involved are poorly understood. Variations in polycomb activity interphase progression have been hypothesized regulate cell-cycle-phase-dependent transcriptional activation genes lineage transition cells. Here, we show that recruitment Polycomb Repressive Complex 1 (PRC1) associated functions, ubiquitination H2AK119...
Coenzyme Q10 (CoQ10) deficiency syndrome is a rare disease included in the family of mitochondrial diseases, which heterogeneous group genetic disorders characterized by defective energy production. CoQ10 biosynthesis humans requires at least 11 gene products acting multiprotein complex within mitochondria. The high-throughput screening (HTS) method based on stabilization CoQ (Q-synthome) produced COQ8 overexpression proven here to be successful for identifying new molecules from natural...
Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and homeostasis. CoQ synthesized by multi-step pathway involves several COQ proteins. Two steps of the eukaryotic pathway, decarboxylation hydroxylation position C1, have remained uncharacterized. Here, we provide evidence these two reactions occur single oxidative step catalyzed COQ4. We demonstrate COQ4 complements an
Abstract The potential of pluripotent cells to respond developmental cues and trigger cell differentiation is enhanced during the G1 phase cycle, but molecular mechanisms involved are poorly understood. Variations in polycomb activity interphase progression have been hypothesized regulate cell-cycle-phase-dependent transcriptional activation genes lineage transition cells. Here, we asked whether Polycomb Repressive Complex 1 (PRC1) modulates ability mouse embryonic stem (ESCs) differentially...