A5015256900- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- HIV Research and Treatment
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Urticaria and Related Conditions
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- RNA Interference and Gene Delivery
- Allergic Rhinitis and Sensitization
- Toxin Mechanisms and Immunotoxins
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Nonmelanoma Skin Cancer Studies
- Management of metastatic bone disease
- Chronic Lymphocytic Leukemia Research
- Ocular Surface and Contact Lens
- Cancer and Skin Lesions
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- Eosinophilic Disorders and Syndromes
- Oral Health Pathology and Treatment
- Immune Cell Function and Interaction
Kanazawa Medical University
2010-2022
Fukushima Medical University
1998-2017
Kanazawa Medical University Hospital
2016
The University of Texas Southwestern Medical Center
2006-2010
St Thomas' Hospital
2003
Imperial Household Agency
1997-1998
Abstract Our recent unbiased functional screen of 54 chemotherapeutic drugs unveiled striking heterogeneity in their effects on dendritic cells (DC). Most notably, vinblastine (VBL) was found to induce phenotypic and maturation DCs vitro. Here, we sought determine whether VBL exhibits “dual” therapeutic efficacy living animals by directly killing tumor boosting host immunity via DC maturation. Local injection a low dose into the skin C57BL/6 mice induced situ epidermal Langerhans cells. When...
Although the precise pathoetiology of Behçet's disease (BD) remains obscure, patients with BD have a high incidence chronic infectious foci, indicating an enhanced susceptibility to tonsillitis, and dental caries. Sometimes, clinical symptoms appear after treatment these foci in patients. It is believed that might be related allergic reaction bacterial infection view many symptoms, especially presence aphthous genital ulcerations. An attempt obtain cutaneous responses antigens has been...
Thymus- and activation-regulated chemokine (TARC/CCL17) its receptor, CC receptor 4 (CCR4), have been proven to be involved in a number of allergic diseases, especially atopic dermatitis (AD). The purpose this study was examine the expression distribution TARC CCR4 mRNAs samples AD (n=15, acute lesions 8, chronic 7) normal skin (n=6). were detected with situ reverse transcription (RT) -polymerase chain reaction (PCR) technique. mRNA expressed epidermal keratinocytes, dermal endothelial cells...
Summary Langerhans cells (LCs) represent a special subset of immature dendritic (DCs) that reside in epithelial tissues at the environmental interfaces. Although dynamic interactions mature DCs with T have been visualized lymph nodes, cellular behaviours linked surveillance for pathogenic signals, an important function DCs, remain unknown. To visualize LCs situ , bone marrow from C57BL/6 mice expressing enhanced green fluorescent protein (EGFP) transgene were transplanted into syngeneic...
Trichophyton infection is highly prevalent and tends to be recurrent. Therefore, it important develop new therapeutic agents. Previously, we established a mouse model of Trichophyton-induced contact hypersensitivity (CHS) demonstrated that dectin-1 was involved in inflammation induced by trichophytin, the antigen. Here, used investigate glycyrrhetinic acid (GA) from plants genus Glycyrrhiza as potential anti-inflammatory agent against superficial mycoses. GA suppressed swelling expression...
Psoriasis features an increased level and activity of tumor necrosis factor alpha (TNF-alpha). The TNF-alpha gene has single nucleotide polymorphisms (SNPs) at positions -308 (-308G>A) -238 (-238G>A) in the promoter region, -238G>A SNP been reported to be associated with psoriasis vulgaris (PV) psoriatic arthritis Caucasians.To examine whether these SNPs are susceptibility PV Japanese patients, we investigated genotype allele frequencies each patients controls.We examined 163 96 healthy...
Arthroderma benhamiae vectored by small animals, such as household pets, causes tinea lesions on human skin. The number of cases caused this species is increasing in Japan. We attempted to develop a simple molecular method for strain discrimination, which expected be useful epidemiology. Out the 61 strains A. registered at our institute, 46 showed very high degrees sequence similarity cluster analysis internal transcribed spacer regions ribosomal RNA (rRNA) genes. These strains, including 22...
Abstract A 90‐year‐old Japanese woman, taking prednisolone (5–10 mg/day) for polyarthritis, presented to our hospital with multiple subcutaneous lesions on her left arm in 2009. Her history included excision of a phaeomycotic cyst the middle finger 2007. There were three nodules approximately 15 mm diameter around wrist and large soft cystic lesion measuring 80 × 60 elbow. granuloma neutrophilic infiltration was detected deep dermis biopsy specimen. Chains composed round brown cells short...
Trichophyton tonsurans has been isolated among judo practitioners, wrestlers, and sumo wrestlers during an epidemic of tinea corporis capitis in Japan. A previous study using restriction fragment length polymorphism (RFLP) analysis the non-transcribed spacer (NTS) region ribosomal RNA gene revealed that different sources for causative fungus epidemics practitioners wrestlers. Many fungal strains have since from these sports. The present evaluated characteristics newly between July 2006...
Abstract We report a 27‐year‐old Japanese woman with Turner syndrome who had generalized pustular psoriasis of the von Zumbusch type. She developed febrile diffuse erythema and eruption without any history preceding vulgaris or drug ingestion. Oral treatment 3.2 mg/kg cyclosporin per day successfully resulted in rapid improvement, followed by complete remission. To our knowledge, this is first describing unusual coexistence these two systemic disorders. discuss hormone imbalance that might...