Hypohidrotic ectodermal dysplasia (HED) is a rare disease. Patients with HED present sparse hair on the head, dysplastic teeth and anhidrosis since childhood, along atopic dermatitis-like skin manifestations. We report 20-year-old male patient who was successfully treated dupilumab. Genetic analysis identified splicing mutation in EDA gene, NG_009809.2 (NM_001399.5):c.793 + 3A>C r.742_793del p.Pro248Ilefs Ter15, which has never been reported before. The subject presented to our...

A 26‐year‐old woman with no family history of dermatophytosis presented pruritic erythema on the right palm ( Fig. 1 ) in November 2002, month after first noticing it. She had lesions soles, toe webs, left palm, or nails. The been treated topical steroids for 4 weeks, but continued to expand. measured 42 mm × 36 mm, and was hyperemic infiltrated unevenly. Its center showed signs healing, its periphery exhibited small vesicles, margin scales. On scales, fungal hyphae chains arthroconidia were...

To determine the relationships among Trichophyton species we constructed three phylogenies, based on nucleotide sequences of actin, rRNA and DNA topoisomerase II genes. These phylogenies showed several conflicting branch points. For example, strains T. verrucosum,T. concentricum mentagrophytes var. erinacei were mingled with Arthroderma benhamiae could not be separated into their own phylogenic groups. In addition, A. vanbreuseghemii, tonsurans, interdigitale quinckeanum simii rubrum...

Arthroderma benhamiae vectored by small animals, such as household pets, causes tinea lesions on human skin. The number of cases caused this species is increasing in Japan. We attempted to develop a simple molecular method for strain discrimination, which expected be useful epidemiology. Out the 61 strains A. registered at our institute, 46 showed very high degrees sequence similarity cluster analysis internal transcribed spacer regions ribosomal RNA (rRNA) genes. These strains, including 22...

In follicular keratosis of the chin, keratotic papules occur on chin and jaw due to localized prolonged pressure friction naked skin. We present one patient with this disorder. The dermatoscopic examination revealed many well-demarcated yellow spindle bodies in patchy lesion. Therapy 1.24R-dihydroxyvitamin D3 ointment was effective during treatment but had no residual positive effect.

A number of cases Trichophyton tonsurans infection have been reported among sportsmen and women participating in wrestling, judo, sumo wrestling Japan, but there also sporadic reports with no history contact these sports. molecular method using restriction enzyme analysis PCR-amplified fragments targeting the non-transcribed spacer region (NTS) ribosomal RNA gene fungal nuclei was applied to T. strains isolated from Japan. Five 6 types recorded i.e., NTS I, II, IV, V, VI, two new types,...

Three genetically hybrid F1 progenies produced between a clinical isolate of Arthroderma simii (KMU4810) and tester strain A. vanbreuseghemii (RV27961) were crossed with two strains (RV27961 RV27960) benhamiae (RV30001), respectively. crossings yielded second progenies. Another interspecies crossing (RV26680) one progeny (Asb57). The (Asb57) (RV30001) many Some confirmed to have genes from three species. gene exchangeability among species was shown the meaning these events discussed.

Abstract A 90‐year‐old Japanese woman, taking prednisolone (5–10 mg/day) for polyarthritis, presented to our hospital with multiple subcutaneous lesions on her left arm in 2009. Her history included excision of a phaeomycotic cyst the middle finger 2007. There were three nodules approximately 15 mm diameter around wrist and large soft cystic lesion measuring 80 × 60 elbow. granuloma neutrophilic infiltration was detected deep dermis biopsy specimen. Chains composed round brown cells short...

プロリダーゼ欠損症（prolidase deficiency：PD）は慢性難治性皮膚潰瘍を主体に多彩な臨床症状を呈する稀な先天性代謝異常症である．本例は，両手背，足背および踵に皮膚潰瘍が散在し，プロリダーゼ酵素活性の低下および同遺伝子変異を認めたことからPDと診断した．胸部画像所見上PDでは過去に報告のない気腫性肺嚢胞が両肺野に多発し，不全型の高IgE症候群合併が考えられた．

Microsporum canis, a major causative agent of zoonotic dermatophytosis, has become prevalent in Japan. Molecular epidemiological surveys using multilocus microsatellite typing (MLMT), sensitive genotyping tool for fungi, have been conducted to reveal intraspecies polymorphisms M. canis.The present study utilized MLMT optimized Japanese strains canis analyze epidemic trends fungal infection. Six individual loci were targeted; namely, MS1, 2, 4, 5, 6, and 7. Analysis data from 1974 through...

We cultured 15 isolates of Trichophyton rubrum and one isolate mentagrophytes from an 82-year-old male tinea patient with multiple lesions. To determine whether feet lesions were the source dermatophytes other lesions, we extracted total cellular DNA T. isolates（13 feet, two right waist buttock）. PCR targeting non-transcribed spacer（NTS）region ribosomal RNA gene was performed. Molecular polymorphisms detected by length variation amplicons.Four molecular types found among isolates. The...

The genotypes and phenotypes of 77 isolates derived from ascospores produced two genetically different Arthroderma benhamiae were studied. Specifically, mitochondrial DNA (mtDNA) type, nuclear (nDNA) mating colony texture, growth rate, urease activity, red pigmentation hair perforation examined. nDNA types based on the restriction fragment length polymorphism (RFLP) in internal transcribed spacer (ITS) region ribosomal RNA (rRNA) genes inherited parents independently. mtDNA type was only one...

A 73-year-old woman developed linear erythema at the sites of scratching-induced scars on bilateral thighs 2 weeks before initial consultation. Subsequently, edematous in upper eyelids, dorsum nose and face, pitting edema hands feet. The C-reactive protein (CRP) level was 8.2 mg/dL erythrocyte sedimentation rate (ESR) 121 mm/h. antinuclear antibody titer 1:160, rheumatoid factor (RF) anti-Jo-1 were negative. X-ray examination showed neither narrowing joint spaces nor bone erosion. Ga...

Trichophyton tonsurans is the most prevalent fungus which causes dermatophytosis among contact sports players in Japan. We previously surveyed epidemic of T. Japan from early 2000, and determined genotypes isolates by analysis restriction enzyme fragment length polymorphisms non-transcription spacer (NTS) region ribosomal RNA gene, enabled discrimination eight genotypes, namely NTS I to VIII. In present study, we performed genotyping isolated between 2016 2020, investigated trend resistance...