A5010335168- Animal Diversity and Health Studies
- Advanced Drug Delivery Systems
- Glaucoma and retinal disorders
- Digestive system and related health
- Protein Hydrolysis and Bioactive Peptides
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Retinal Imaging and Analysis
- Phytochemistry and Biological Activities
- Advancements in Battery Materials
- PI3K/AKT/mTOR signaling in cancer
- Drug Solubulity and Delivery Systems
- Medicinal Plants and Neuroprotection
- Traditional Chinese Medicine Analysis
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Advancements in Transdermal Drug Delivery
- Pomegranate: compositions and health benefits
- Phytochemicals and Medicinal Plants
- Transgenic Plants and Applications
- Curcumin's Biomedical Applications
- Poisoning and overdose treatments
- Computational Drug Discovery Methods
- Antioxidants, Aging, Portulaca oleracea
- Carbon and Quantum Dots Applications
Khalifa University of Science and Technology
2023-2025
University of Malakand
2018-2025
United Arab Emirates University
2021-2023
Babasaheb Bhimrao Ambedkar University
2021
Quaid-i-Azam University
2021
China Medical University
2020
University of Peshawar
2006
ABSTRACT Polygonum plebeium , a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, inflammation, dysentery, eczema ringworms, other skin conditions. Many studies have suggested that plants belonging this genus possess strong cardio‐protective potentials. Rats were pre‐treated with crude methanolic extract fractions at dose 500...
In dairy science, camel milk (CM) constitutes a center of interest for scientists due to its known beneficial effect on diabetes as demonstrated in many vitro, vivo, and clinical studies trials. Overall, CM had positive effects various parameters related glucose transport metabolism well the structural functional properties pancreatic β-cells insulin secretion. Thus, consumption may help manage diabetes; however, such recommendation will become rationale clinically conceivable only if exact...
Introduction: Datura stramonium (DS) possesses strong medicinal and therapeutic potential but has been rarely evaluated in this context. Methods: The present study was intended to evaluate the antioxidant, hepatoprotective, nephroprotective of crude methanolic leaf extract ethyl acetate, chloroform, n-hexane, aqueous fractions DS paracetamol-intoxicated rabbits. Paracetamol (2 g/Kg BW) applied induce liver kidney injury rabbits while were dose range 150 mg/Kg 300 body weight for 21 days....
We previously identified protein hydrolysates from camel milk (CM) targeting dipeptidyl peptidase IV (DPP-IV) and insulin receptor (IR) activity. In this study, we synthesized nine peptides (P1 to P9) derived such CM profiled their potential bioactivity in vitro silico . This aims validate determine if synthetic pure CM-derived are bioactive on IR function glucose uptake using pharmacological functional approaches human embryonic kidney (HEK293) hepato-carcinoma (HepG2) cells. Our...
Two-dimensional (2D) nanomaterials have garnered enormous attention seemingly due to their unusual architecture and properties. Graphene graphene oxide based 2D remained the most sought after for several years but quest design superior which can find wider application gave rise development of non-graphene materials as well. Consequently, in addition nanomaterials, nanostructures designed using macromolecules (such DNAs, proteins, peptides peptoids), transition metal dichalcogenides,...
Lactoferrin (LF) is a milk protein that may be an interesting candidate for the antidiabetic properties of due to its well-documented bioactivity and implication in diabetes. Here, we investigated functional action LF purified from camel bovine (cLF, bLF) on insulin receptors (IR) their pharmacology signaling hepatocarcinoma (HepG2) human embryonic kidney (HEK293) cells. For this, examined IR activation by bioluminescence resonance energy transfer (BRET) technology phosphorylation key...
Ziziphus oxyphylla Edgew is in folk use Pakistan as an analgesic, anti-inflammatory, and liver ailments. Therefore, we have investigated antioxidant, antinociceptive, hepatoprotective activities of the isolated compounds (ceanothic acid zizybrenalic acid) from chloroform fraction Z. oxyphylla. Ceanothic showed significant DPPH H2O2 scavenging activity compared to control. In acute toxicity study, ceanothic no toxic effects upto 200 mg/kg. The antinociceptive shown by at 50 mg/kg was 64.28%...
Portulacca oleracea L. has been used for treatment of different ailments. The aim this study was to investigate the effectiveness and possible mechanism action involved in anti gastric ulcerogenic effect oleracea. Methanolic extract & subsequent fractions (100, 200 400 mg/kg) (P. oleracea) were administered orally experimental rabbits one hour before oral administration HCl/ethanol (40:60). Anti potential P. evaluated by assessment pH, pepsin, free acidity, ulcer index, mucus content total...
(RW) Wall Ex. Royle is used in traditional medicine Pakistan for the treatment of several diseases including jaundice. To date, only neuroprotective potential plant has been evaluated.
The Biopharmaceutical Classification System (BCS) classifies drugs on the basis of solubility and permeability. Ketoconazole belongs to class II which are characterized by high permeability but low issues. current research work aimed formulate optimized nano-formulation for ketoconazole altering stirring time, speed, ingredient ratios. In this study, a speed minimum 600 rpm maximum 1200 was used. time 7 minutes 30 noted. Olive oil used as lipid, Tween 80 incorporated surfactant, polyethylene...
Ketoconazole belongs to the class II drugs of biopharmaceutical classification system and has low solubility issues. In market, available drug ketoconazole is 200-400 mg associated with solubility. To cope these issues nanoemulsion formulated. During fabrication nanoemulsion, olive oil was used as a lipid, tween 80 surfactant, PEG 600 co-surfactant. By changing ratios surfactants co-surfactants, formulations different particle sizes polydispersity index were obtained. The optimized...
Folklorically, Viola canescens (VC) is used for the treatment of respiratory disorders, such as cough and asthma. The current study aimed to evaluate VC anti-asthmatic anti-tussive activities isolate bioactive compound. plant was collected, extracted, fractionated, with isolation compounds via column chromatography. Solvent extracts were evaluated in animal models. purified compound obtained from ethyl acetate fraction (EF) chromatography identified by Mass 1H-NMR spectroscopic techniques....
Current study focused on resolution of poor oral bioavailability issues cefixime through fabrication its freeze dried binary solid lipid nano particles (SLNs). The formulation fabricated via hot melt encapsulation (HME) method was optimized using numerous variables. Optimized (CFX-4) showed particle size 206.6±2.3 nm, polydispersity index (PDI) 0.271±0.03, zeta potential (ZP) -30.7±3.1 mV, efficiency (EE%) 88.2±2.3% along with drug loading capacity (DLC%) 4.83±0.16%. Micrograph scanning...