A5057635700- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Connexins and lens biology
- Hormonal Regulation and Hypertension
- Thermoregulation and physiological responses
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Estrogen and related hormone effects
- Metabolism and Genetic Disorders
- Cardiovascular Health and Disease Prevention
- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Ovarian function and disorders
- High Altitude and Hypoxia
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Phonetics and Phonology Research
- Organ Donation and Transplantation
- Muscle metabolism and nutrition
- Hypothalamic control of reproductive hormones
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Organ Transplantation Techniques and Outcomes
- Voice and Speech Disorders
University of Copenhagen
1985-2024
Universidad de Salamanca
2010
University of Gothenburg
2009
Leipzig University
2009
Universität Greifswald
1998
Rigshospitalet
1974-1990
Statens Serum Institut
1985-1986
Glostrup Hospital
1974
SUMMARY Serum levels of sex hormone binding globulin (SHBG), testosterone, free dihydrotestosterone, androstenedione, dehydroepiandrosterone sulphate, oestradiol, oestrone, oestrone FSH, and LH were measured in 20 steroid sulphatase‐deficient men with recessive X‐linked ichthyosis normal men. The serum sulphate level was significantly higher than the patients ( P < 0·0001). In affected men, there a tendency towards no decline age seen as opposed to (interaction: 0·025). oestradiol lower...
We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 2 independent cohorts. In a rat model with loss of RBM20, we demonstrated altered sarcomere genes (NEXN, TTN, TPM1, MYOM1, LDB3), differential expression key genes. identified mitochondrial structure on electron microscopy imaging found compromised function. Finally, that 3 novel LOF patients fibrillation, lead to significantly reduced activity. Our results...
Abstract The present study examined and compared the impact of exercise training on redox molecular properties human microvascular endothelial cells derived from skeletal muscle biopsies sedentary recent (RPF, ≤ 5 years as postmenopausal) late (LPF, ≥ 10 postmenopausal females. Resting were obtained before after 8 weeks intense aerobic for isolation determination angiogenic proteins capillarisation. analysed mitochondrial respiration production reactive oxygen species (ROS), glycolysis...
Glucagon-like peptide-1 (GLP-1) is an incretin hormone known to stimulate postprandial insulin release. However, GLP-1 also exerts extrapancreatic effects, including renal effects. Some of these effects are attenuated in hypertensive rats, where expression receptors reduced. Here, we assessed the and vascular function kidneys from young prehypertensive rats. We examined GLP-1-induced vasodilation vasculature wild-type (WT) receptor knockout mice using wire pressure myography isolated...
Henriksen, F. W., Jörgensen. S. P. & Möller, Interaction between secretin and cholecystokinin on inhibition of gastric secretion in man. Scand. J. Gastroent. 1974, 9, 735–740.The inhibitory effect (0.5 1.0 clinical units/kg b.w./h) Ivy dog b.w./h), given alone or combination, the pentagastrin-stimulated (0.15–1.0–6.0 µg/kg secretion, was investigated 12 volunteers. At low dose-levels agents, exogenously, an augmented acid observed when were combination. Since doses used most likely within...
Glycosaminoglycans (GAGs) occur in many tissues. There is increasing evidence that the sulfation of GAGs does not at random, but a “sulfation code” exists mediates physiological functions GAGs. Therefore, certain might also have interesting pharmacological properties. We will give here an overview on chemical functionalization strategies hyaluronan (HA) and chondroitin/ dermatan sulfate (CS/DS). This challenging task from synthetic as well analytical viewpoint because both, regioselective...
The aim of this study is to examine whether colchicine improves β adrenoceptor-mediated vasodilation in humans by conducting a double-blinded, placebo-controlled intervention study. Colchicine treatment has known beneficial effects on cardiovascular health and reduces the incidence disease. Studies isolated rodent arteries have shown that can enhance vasodilation, but not been determined humans.Middle-aged men with essential hypertension were randomly assigned firstly acute either 0.5 mg (n...
This study tested the hypothesis that training reduces resting sympathetic activity and improves baroreflex control in both hypertensive normotensive men but blood pressure only men.Middle-aged/older un-medicated stage-1 males (mean age 55 ± 3 years; n = 13) controls 60 5 12) participated 8 weeks of supervised high-intensity interval spinning training. Before after training, muscle nerve (MSNA) were measured at rest during a sympatho-excitatory cold pressor test (CPT). Based on measurements,...
Aerobic training can improve vascular endothelial function in-vivo. The aim of this study was to elucidate the mechanisms underlying improvement in isolated human microvascular cells. Sedentary males, aged 57 ± 6 years completed 8 weeks intense aerobic training. Resting muscle biopsies were obtained from thigh and used for isolation cells (pre n = 23, post 16). analyzed mitochondrial respiration, H2O2 emission, glycolysis, protein levels antioxidants, NADPH oxidase, nitric oxide (NO)...
In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive purinergic receptors smooth muscle cells. opening is proposed mediated by α-adrenergic potentiate sympathetic constriction. This positions as a putative pharmacological target humans. The aim was provide first translational evidence for role of essential hypertension humans use...
We investigated the influence of a specific serotonin receptor blockade on pituitary hormone secretion in normal cycling women and postmenopausal not receiving replacement therapy. Serotonin was performed by using HT-3 subtype antagonist ondansetron as an i.v. bolus injection 8 mg. Blood samples were taken before well 20, 30 40 min after administration for estimation LH, FSH, TSH. could find any hormonal changes women. The showed significant decline LH secretion, whereas FSH TSH levels...
Apoptosis appears to play an important role in the development of diabetes non-obese diabetic (NOD) mouse. Since autoimmune process leading manifestation insulin dependent mellitus (IDDM) can also affect sympathochromaffin system, we analyzed apoptosis and infiltration adrenal medulla as features this parallel with diabetes.
Renal autoregulation is mediated by the myogenic response and tubuloglomerular feedback (TGF) working in concert to maintain renal blood flow glomerular filtration rate despite fluctuations perfusion pressure. Intercellular communication through gap junctions may play a role autoregulation. We examine if one of building blocks junctions, connexin45 (Cx45), which expressed vascular smooth muscle cells, has an influence on autoregulatory efficiency. The isolated perfused juxtamedullary nephron...
The vasoconstrictive effect of sympathetic activity is attenuated in contracting skeletal muscle (functional sympatholysis), allowing increased blood supply to the working but underlying mechanisms are incompletely understood. purpose this study was examine α-adrenergic receptor responsiveness isolated artery segments from non-exercised and exercised mice, using wire myography. Isometric tension recordings performed on femoral mice showed decreased compared (logEC50 −5.2 ± 0.04 M vs. −5.7...
The juxtaglomerular apparatus (JGA) is an essential structure in the regulation of renal function. JGA embodies two major functions: tubuloglomerular feedback (TGF) and renin secretion. TGF one mechanisms mediating autoregulation. It initiated by increase tubular NaCl concentration at macula densa cells. This induces a local afferent arteriolar vasoconstriction conducted response that can be measured several 100 μm upstream from segment. spread vasomotor into surrounding vasculature likely...
Type 2 diabetes (T2D) is associated with vascular endothelial dysfunction and microvascular rarefaction in skeletal muscle tissue (1). Although metabolic disease proposed to be altered cell metabolism, there date a paucity of human data support this notion. The aim study was investigate the metabolism cells derived from biopsies. Moreover, as exercise training known reverse promote angiogenesis, effect period assessed. Microvascular were isolated m. vastus lateralis biopsies taken obese...
ABSTRACT Introduction Regular exercise training reduces arterial blood pressure, but the underlying mechanisms are unclear. Here, we evaluated potential involvement of pannexin 1, an ATP releasing channel, in pressure–reducing effect training. Methods Middle-age men, 13 normotensive and 14 nonmedicated stage 1 hypertensive, completed 8 wk intensive aerobic cycle Before after training, pressure changes leg vascular conductance, induced by femoral infusion tyramine (induces endogenous...
The kidney maintains constant renal blood flow and glomerular filtration rate despite acute changes in perfusion pressure (RPP) via autoregulation. Renal autoregulation is made up of the myogenic response tubuloglomerular feedback (TGF) mechanism, both acting on afferent arteriole. Both mechanisms have a conducted component, believed to proceed gap junctions (GJ). These fluid‐filled pores are two connexons, one from each cell, with connexins (Cx) as building blocks. Several Cx isoforms...
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