A5028286372- Calcium Carbonate Crystallization and Inhibition
- Bone Tissue Engineering Materials
- Paleontology and Stratigraphy of Fossils
- Crystallization and Solubility Studies
- Cephalopods and Marine Biology
- Diatoms and Algae Research
- Marine Biology and Environmental Chemistry
- Enzyme Structure and Function
- Building materials and conservation
- Marine Sponges and Natural Products
- Clay minerals and soil interactions
- Immune Cell Function and Interaction
- Crystallography and molecular interactions
- Material Dynamics and Properties
- Polymer Surface Interaction Studies
- Immunotherapy and Immune Responses
- Liquid Crystal Research Advancements
- Surface Modification and Superhydrophobicity
- Minerals Flotation and Separation Techniques
- Phosphorus and nutrient management
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Hydrocarbon exploration and reservoir analysis
- Surface Chemistry and Catalysis
- Analytical chemistry methods development
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015-2024
Materials Science & Engineering
2023
Institute of Glass
2019-2020
Bayer (Germany)
2020
Harvard University
2019
Massachusetts General Hospital
2019
Shriners Hospitals for Children - Galveston
2019
Ithaca College
2015
Université de Bourgogne
2011-2014
Cornell University
2014
Immunity against the intracellular protozoan Toxoplasma gondii is highly dependent on interferon gamma (IFN-gamma). We have previously shown that, in addition to T lymphocytes, natural killer (NK) cells can be stimulated by parasite produce this cytokine a reaction requiring adherent accessory and tumor necrosis factor alpha. now demonstrate that recently characterized cytokine, interleukin 12 (IL-12), also necessary for parasite-induced IFN-gamma synthesis NK cells. Anti-IL-12 antibodies...
Abstract IL-12, a cytokine produced by macrophages and B cells, has recently been found to exert pleiotropic effects on the immune system. When BALB/c mice, strain highly susceptible virulent Mycobacterium tuberculosis infection, were given IL-12 at initiation of infection with M. tuberculosis, their mean survival time doubled from 58 112 days. IL-12-treated mice had diminished bacterial burdens, whereas treatment exogenous IFN-gamma no effect or burden. also delayed lung pathology in mice....
An in situ study of the contact-free crystallization calcium carbonate acoustic levitated droplets is reported. The droplet technique allows an monitoring while avoiding any foreign phase boundaries that may influence precipitation process by heterogeneous nucleation. diffusion-controlled CaCO3 at neutral pH starts initial step with homogeneous formation a stable, nanosized liquid-like amorphous undergoes subsequent solution-assisted transformation to calcite. Cryogenic scanning electron...
"Non-classical" notions consider formation pathways of crystalline materials where larger species than monomeric chemical constituents, i.e., ions or single molecules, play crucial roles, which are not covered by the classical theories dating back to 1870s and 1920s. Providing an outline "non-classical" nucleation, we demonstrate that prenucleation clusters (PNCs) can lie on alternative phase separation, very event demixing is primarily based sizes forming, as in view, but their dynamics....
The impact of the ovo proteins ovalbumin and lysozyme--present in first stage egg shell formation--on homogeneous formation liquid amorphous calcium carbonate (LACC) precursor, was studied by a combination complementing methods: situ WAXS, SANS, XANES, TEM, immunogold labeling. Lysozyme (pI = 9.3) destabilizes LACC emulsion whereas glycoprotein 4.7) extends lifespan emulsified state remarkably. In light presented data: (a) Ovalbumin is shown to behave commensurable 'polymer-induced...
During the mineralisation of metal carbonates MCO3 (M = Ca, Sr, Ba, Mn, Cd, Pb) liquid-like amorphous intermediates emerge. These that form via a liquid/liquid phase separation behave like classical emulsion and are stabilized electrostatically. The occurrence these is attributed to formation highly hydrated networks whose stability mainly based on weak interactions variability metal-containing pre-critical clusters. Their existence compositional freedom evidenced by electrospray ionization...
The biomineral phase of avian eggshell is characterized at the nanostructure scale and correlated with functional properties.
Abstract The combination of soft nanoscale organic components with inorganic nanograins hierarchically designed by natural organisms results in highly ductile structural materials that can withstand mechanical impact and exhibit high resilience on the macro- nano-scale. Our investigation nacre deformation reveals underlying nanomechanics govern absorption energy. Using high-resolution scanning/transmission electron microscopy (S/TEM) combined situ indentation, we observe recovery heavily...
Mineralization of calcium carbonate in aqueous solutions starting from its initiation was studied by time-resolved small-angle neutron scattering (SANS). SANS revealed that homogeneous crystallization CaCO3 involves an initial formation thin plate-shaped nuclei which subsequently reassemble to 3-dimensional particles, first fractal and finally compact structure. The presence the egg-white protein ovalbumin leads a different progression mineralization through several stages; step represents...
Natural nacre exhibits extraordinary functional and structural diversity, combining high strength toughness. The mechanical properties of are attributed to (i) a highly arranged hierarchical layered structure inorganic minerals (95 vol %) containing small amount only organic materials (5 %), (ii) abundant synergistic interfacial interactions, (iii) formation under ambient temperature. Herein, inspired by these three design principles originating from natural nacre, the supertough bioinspired...
Intricate biomineralization processes in molluscs engineer hierarchical structures with meso-, nano-, and atomic architectures that give the final composite material exceptional mechanical strength optical iridescence on macroscale. This multiscale biological assembly inspires new synthetic routes to complex materials. Our investigation of prism-nacre interface reveals nanoscale details governing onset nacre formation using high-resolution scanning transmission electron microscopy. A wedge...
Calcium carbonate is an abundant biomineral, and already archeological records demonstrate its bioactivity applicability for osseo-integrative implants. Its solubility, which generally higher than those of calcium phosphates, depends on polymorph turning into a promising biomaterial with tunable bioresorption rate. However, the phase-dependent carbonate, i.e., osteoconductivity, still insufficiently characterized. In this study, we address issue by monitoring behavior four most important...
Understanding the underlying processes of biomineralization is crucial to a range disciplines allowing us quantify effects climate change on marine organisms, decipher details paleoclimate records and advance development biomimetic materials. Many biological minerals form via intermediate amorphous phases, which are hard characterize due their transient nature lack long-range order. Here, using Monte Carlo simulations constrained by X-ray neutron scattering data together with model building,...
Siliceous sponges can synthesize poly(silicate) for their spicules enzymatically using silicatein. We found that silicatein exists in silica‐filled cell organelles (silicasomes) transport the enzyme to spicules. show first time recombinant acts as a silica polymerase and also esterase. The enzymatic polymerization/polycondensation of silicic acid follows distinct course. In addition, we cleaves ester‐like bond bis( p ‐aminophenoxy)‐dimethylsilane. Enzymatic parameters esterase activity are...
Tuning the pseudomorphic transformation of calcium carbonate allows for generation crystal lattice tilting similar to that found in calcareous biominerals.
On the phase of it: The selection calcium carbonate (spheres: C gray, Ca green, O red) is determined by chiral amino acids (stick models) present during crystallization. interplay composition and chirality crystal surfaces additives leads to enantiospecific adsorption D L on surface steps. resulting passivation creates a kinetic barrier, which controls selection. Supporting information for this article available WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700010_s.pdf or from...
The calcitic prisms of Pinna nobilis (Pinnidae, Linnaeus 1758) are shown to be perfect examples a mesocrystalline material. Based on their ultrastructure and the occurrence an amorphous transient precursor during early stages prism formation, we provide evidence for pathway mesocrystallisation proposed by Seto et al. (2012), which proceeds not self-organized oriented attachment crystalline nano-bricks but aggregation initially nanogranules later transform epitaxial nucleation...
Abstract Bombyx mori silks possess great potential in textile industries due to the large‐scale green production. However, demand for with functional as well mechanical properties are continuously rising emergence of other textiles. It remains a challenge functionalize natural silk and simultaneously improve its properties. Inspired by relationship between core–sheath structure cocoon silk, application thin reduced graphene oxide (rGO) layer coated B. (GS) is shown via hydrogen interfacial...