A5007283676- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Bee Products Chemical Analysis
- Selenium in Biological Systems
- Kruppel-like factors research
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Seaweed-derived Bioactive Compounds
University of Jeddah
2020-2024
Imperial College London
2019-2020
King Abdulaziz University
2019
Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects flow-activated transcription factor Krüppel-like 2 (KLF2) are compromised in PAH. Here, we show KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular remodelling their actions mediated by Notch4 ETS1 other key regulators homoeostasis. Expressions KLF2, reduced, while levels target genes elevated...
Abstract Gold nanoparticles (Au-NPs) have several uses for nanobiotechnologists because of their beneficial biomedical properties. Alginates various and industrial applications. The aim this study is to extract alginate from Azotobacter chroococcum , synthesize chemical Au-NPs (Ch/Au-NPs), load the NPs with extracted form gold nanocomposites (Azto/Alg-Au-NCMs). Ch/Au-NPs Azto/Alg-Au-NCMs were characterized by UV-spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, energy-dispersive...
Cancer is a threatening disease that needs strong therapy with fewer side effects. A lot of different types chemotherapy or chemo-drugs are used in cancer treatments but have many The increasing number antibiotic-resistant microorganisms requires more study new antimicrobial compounds and delivery targeting strategies. This work aims to isolate identify
ABSTRACT Flow-activated transcription factor Krüppel-like 2 (KLF2) signaling is compromised in pulmonary arterial hypertension (PAH). We aimed to identify KLF2-induced endothelium-protective exosomal microRNAs of potential therapeutic significance. Eight elevated by KLF2 but reduced PAH were transfected into human artery endothelial cells. Of these, only miR-181a-5p and miR-324-5p had anti-apoptotic, anti-inflammatory anti-proliferative effect on cells proliferation vascular smooth muscle...