A5074112347- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Exercise and Physiological Responses
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Liver physiology and pathology
- Heart Rate Variability and Autonomic Control
- Antioxidant Activity and Oxidative Stress
- Pharmacogenetics and Drug Metabolism
- Pulmonary Hypertension Research and Treatments
- Cardiac Health and Mental Health
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Protein Tyrosine Phosphatases
- Pancreatic and Hepatic Oncology Research
- Neurological Disorders and Treatments
- Circular RNAs in diseases
- Silymarin and Mushroom Poisoning
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
- Pharmacy and Medical Practices
- Chemotherapy-induced cardiotoxicity and mitigation
University of Liverpool
2020-2023
Medical Research Council
2021-2022
Imperial College London
2019-2020
University of Naples Federico II
2011-2018
University of Salerno
2012-2017
University of Campania "Luigi Vanvitelli"
2011
Abstract Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects flow-activated transcription factor Krüppel-like 2 (KLF2) are compromised in PAH. Here, we show KLF2-induced exosomal microRNAs, miR-181a-5p and miR-324-5p act together to attenuate pulmonary vascular remodelling their actions mediated by Notch4 ETS1 other key regulators homoeostasis. Expressions KLF2, reduced, while levels target genes elevated...
The present study investigated the effect of two single nucleotide polymorphisms (SNPs) vitamin D receptor (VDR) gene, rs1544410 A/G and rs2228570 C/T, in modulating bone mineral density (BMD) response to treatment with bisphosphonates or strontium ranelate postmenopausal osteoporosis (PMO). Four hundred eighteen women from Southern Italy treated for three years were enrolled stratified according their genotype. Changes BMD expressed as delta t-score (Δt-score). Allelic frequencies A/GSNP...
An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it underutilized, especially the elderly. While functional and hemodynamic effects of CRP are well known, its underlying molecular mechanisms have not been fully clarified. The present study aims to evaluate a well-structured 4-week patients with stable HF from point view.A prospective longitudinal observational was conducted on consecutively admitted cardiac...
Background and Aims The transcription factor nuclear erythroid 2‐related 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in transgenic mice have led to conflicting reports on its role liver regeneration. We aimed test the hypothesis that pharmacological activation Nrf2 would enhance Approach Results Wild‐type null were administered bardoxolone methyl (CDDO‐Me), a potent activator has entered clinical development, then subjected two‐thirds partial hepatectomy. Using...
Predicting which drugs might have the potential to cause drug-induced liver injury (DILI) is highly complex and current methods, 2D cell-based models animal tests, are not sensitive enough prevent some costly failures in clinical trials or avoid all patient safety concerns for DILI post-market. Animal-based methods hampered by important species differences metabolism adaptive immunity compared humans standard vitro approaches limited metabolic functionality complexity. On 24 April 2023...
Exercise training is a nonpharmacological intervention that improves cardiovascular function and enhances endothelial homeostasis in patients with diseases. However, the amount of benefit achieved varies widely depending on type duration exercise. Moreover, data about long-term effects physical activity are scarce.In this study, cells, exposed or not to oxidative stress, were conditioned sera from athletes regularly participating sports classified as "aerobic" (triathlon), "mixed...
Moderate aerobic exercise reduces oxidative stress, whereas intense physical activity may produce the opposite result. At present, effects of different loads on stress markers and response human cells to volumes have not been fully elucidated.Human (Eahy-926) endothelial (EC), exposed or were conditioned with sera from two groups triathletes practicing at workloads.Although no differences in functional hemodynamic variables observed between triathletes, significant changes some for found...
Increased expression of CLIC4 (chloride intracellular channel 4) is a feature endothelial dysfunction in pulmonary arterial hypertension, but its role disease pathology not fully understood.To identify effectors and evaluate strategies targeting signaling hypertension.Proteomic analysis CLIC4-interacting proteins human artery cells identified regulators endosomal trafficking, including Arf6 (ADP ribosylation factor 6) GTPase activating clathrin, while overexpression affected protein...
To evaluate the impact of an educational strategy on potentially inappropriate medications (PIMs) and length stay in hospitalized elderly patients. Design: An open study, with two cross-sectional surveys interspersed program (PRE phase POST phase), has been performed order to compare PIMs number before after introduction strategy. The study included 2 phases: PRE, which patients were enrolled as control group; POST, use was introduced among physicians, intervention group. Setting: Italian...
Circulating levels of endothelial miR-150 are reduced in pulmonary arterial hypertension (PAH) and act as an independent predictor patient survival, but links between vascular dysfunction not well understood. We studied the effects supplementation inhibition PAH mice cells from patients with idiopathic PAH. The role selected mediators identified by RNA sequencing was evaluated vitro vivo. Endothelium-targeted delivery prevented disease Sugen/hypoxia mice, while knockdown had adverse effects....
Aim Serum microRNA‐122 (miR‐122) is a novel biomarker for drug‐induced liver injury, with good sensitivity in the early diagnosis of paracetamol‐induced injury. We describe miR‐122 concentrations participants antituberculosis injury (AT‐DILI). explored relationship between and alanine aminotransferase (ALT) effect N‐acetylcysteine (NAC) on concentrations. Methods included from randomized placebo‐controlled trial intravenous NAC AT‐DILI. ALT were quantified before after infusion NAC/placebo....
Aim: To compare levels of oxidative stress markers in patients9 sera with non-alcoholic steatohepatitis (NASH) treated for 12 months (T<sub>12</sub>) silybin conjugated phosphatidylcholine (Realsil®) (R) or placebo (P) and investigate responses human endothelial cells conditioned sera. Patients Methods: We recruited twenty-seven patients histological NASH. measured thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) catalase (CAT) activities exposed not to...
To minimize the occurrence of unexpected toxicities in early phase preclinical studies new drugs, it is vital to understand fundamental similarities and differences between species humans. Species sensitivity acetaminophen (APAP) liver injury have been related fraction drug that bioactivated reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). We used physiologically based pharmacokinetic modeling identify oral doses APAP (300 1000 mg/kg mice rats, respectively) yielding similar hepatic...
Mitochondrial fission and a metabolic switch from oxidative phosphorylation to glycolysis are key features of vascular pathology in pulmonary arterial hypertension (PAH) associated with exuberant endothelial proliferation apoptosis. The underlying mechanisms poorly understood. We describe the contribution two intracellular chloride channel proteins, CLIC1 CLIC4, both highly expressed PAH cancer, mitochondrial dysfunction energy metabolism endothelium. Pathological overexpression CLIC...
The chronic arthropathies currently appear to be a major cause of disability with negative impact on quality life and health care spending. mud-bath therapy is spa treatment that induces benefic effects in rheumatic diseases. It has long been debated the assumption could have adverse cardiovascular which often induce caution even contraindication use this associated alterations such as hypertension. aim observational study was investigate, arthrorheumatic subjects, sulphureous cycle blood...