A5068169028- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Prostate Cancer Treatment and Research
- Cancer Mechanisms and Therapy
- Peroxisome Proliferator-Activated Receptors
- Pituitary Gland Disorders and Treatments
- Neuropeptides and Animal Physiology
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Pancreatic and Hepatic Oncology Research
- Growth Hormone and Insulin-like Growth Factors
- Protein Hydrolysis and Bioactive Peptides
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- Zebrafish Biomedical Research Applications
- Heat shock proteins research
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
University of Milan
2013-2024
IRCCS Istituto Auxologico Italiano
2010-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2021
University of Campania "Luigi Vanvitelli"
2006-2011
University of Naples Federico II
2005-2010
Abstract Bioactive peptides are present in a latent state, encrypted within the amino acid sequence of milk proteins, requiring enzymatic proteolysis for their release. They can be produced by gastrointestinal digestion or food processing, thus they fermented milks, cheese and also by‐products dairy industry such as waste whey. The spectrum biological activity covered milk‐derived is extremely wide, including antibacterial, immunostimulating, antihypertensive, antithrombotic opioid actions....
Hepatocellular carcinoma (HCC) results from accumulation of both genetic and epigenetic alterations. We investigated the genome-wide DNA methylation profile in 69 pairs HCC adjacent non-cancerous liver tissues using Infinium HumanMethylation 450K BeadChip array. An innovative analytical approach has been adopted to identify Stochastic Epigenetic Mutations (SEMs) HCC.HCC peritumoral showed a different profile, mainly characterized by loss HCC. Total number SEMs was significantly higher tumor...
Exercise training is a nonpharmacological intervention that improves cardiovascular function and enhances endothelial homeostasis in patients with diseases. However, the amount of benefit achieved varies widely depending on type duration exercise. Moreover, data about long-term effects physical activity are scarce.In this study, cells, exposed or not to oxidative stress, were conditioned sera from athletes regularly participating sports classified as "aerobic" (triathlon), "mixed...
Everolimus, an mTOR inhibitor, which has been demonstrated to induce anti-tumour effects in different types of neuroendocrine tumours, never evaluated patients with medullary thyroid cancer (MTC). The aim this study was evaluate the vitro and vivo everolimus combination octreotide MTC. Two progressive metastatic MTC high calcitonin levels were treated 5-10 mg/day. Both under treatment LAR at entry. An also performed assess on cell lines (TT MZ-CRC-1 cells). A tumour response observed both...
Milk proteins are a source of bioactive peptides. Recent studies have indicated that protein-derived peptides released in buffalo cheese acid whey exert cytomodulatory effect human epithelial colon cancer (CaCo2) cells. The aim the present study was to explain molecular mechanism involved response CaCo2 cells oxidative stress presence peptide fractions whey, purified and characterized by mass spectrometry.We demonstrated treatment treated with H2O2 (H-CaCo2) partially sub-fraction (f3) from...
Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), demethylating agent, in combination with mTOR inhibitor everolimus MTC cells (MZ-CRC-1 TT). This combined treatment showed strong synergistic antiproliferative activity through induction apoptosis. The effect...
The insulin receptor isoform A (IR-A) plays an increasingly recognized role in fetal growth and tumor biology response to circulating and/or locally produced IGF2. This seems not be shared by the IR B (IR-B). We aimed dissect specific impact of isoforms modulating signaling triple negative breast cancer (TNBC) cells. generated murine 4T1 TNBC cells deleted from endogenous (
To date no efficacious treatments are available for advanced medullary thyroid carcinoma (MTC). We investigated in vitro and vivo a new strategy the therapy of MTC, combining human recombinant IL-2 with lanreotide (LAN), somatostatin analog. The effects LAN on sensitivity TT cells, MTC cell line, to IL-2–stimulated peripheral blood mononuclear cells were determined by lactate dehydrogenase release assay. In addition, we evaluated toxicity, quality life, antitumor activity sc low-dose...
Type I interferons (IFNs) represent a group of cytokines that act through common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro vivo studies showed potent antitumor activity induced these cytokines. IFN-, the first cytokine to be produced recombinant DNA technology, has emerged as an important regulator cancer cell growth differentiation, affecting cellular communication signal transduction pathways. is currently most used treatment cancer. However, potential...
Medullary thyroid carcinoma (MTC) is a tumor deriving from the C cells. Vandetanib (VAN) and cabozantinib (CAB) are two tyrosine kinase inhibitors targeting REarranged during Transfection (RET) other receptors approved for treatment of advanced MTC. We aim to compare in vitro vivo anti-tumor activity VAN CAB The effects on viability, cell cycle, apoptosis TT MZ-CRC-1 cells evaluated using an MTT assay, DNA flow cytometry with propidium iodide, Annexin V-FITC/propidium iodide staining,...
Breast cancer, a leading cause of cancer related deaths worldwide, is one the most common neoplasms in women. The increased generation reactive oxygen species (ROS) breast lesion critically involved mutagenic processes that drive to carcinoma initiation and progression. To date, molecular events occurring tissue adjoin have not been elucidated. Here, we investigated role excess ROS during human carcinogenesis by evaluating oxidative stress biomarkers, transglutaminase (t-TGase) activity,...