A5103250684- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Adrenal and Paraganglionic Tumors
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Hormonal Regulation and Hypertension
- Vascular Malformations and Hemangiomas
- Gallbladder and Bile Duct Disorders
- Thyroid and Parathyroid Surgery
- Renal and Vascular Pathologies
- Congenital Anomalies and Fetal Surgery
- Pancreatic and Hepatic Oncology Research
- Parathyroid Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Biliary and Gastrointestinal Fistulas
- Vascular anomalies and interventions
- Peripheral Nerve Disorders
- Abdominal vascular conditions and treatments
- Phagocytosis and Immune Regulation
- Teratomas and Epidermoid Cysts
- Kidney Stones and Urolithiasis Treatments
Ospedale San Carlo
2016-2019
Federico II University Hospital
2012-2018
University of Naples Federico II
2009-2011
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2010
Everolimus, an mTOR inhibitor, which has been demonstrated to induce anti-tumour effects in different types of neuroendocrine tumours, never evaluated patients with medullary thyroid cancer (MTC). The aim this study was evaluate the vitro and vivo everolimus combination octreotide MTC. Two progressive metastatic MTC high calcitonin levels were treated 5-10 mg/day. Both under treatment LAR at entry. An also performed assess on cell lines (TT MZ-CRC-1 cells). A tumour response observed both...
Neuroendocrine tumors (NETs) can be sporadic or they arise in complex hereditary syndromes. Patients with NETs identified before the development of by performing genetic screenings. The aim study was to evaluate clinical and prognostic impact a preclinical screening subjects NET 46 referred for syndrome [22 MEN1, 12 MEN2, Familial Paragangliomatosis (FPGL)] were enrolled divided 2 groups (group A, 20 appearance diagnosis; group B, 26 diagnosis syndromes NETs). main outcome measures severity...
Medullary thyroid carcinoma (MTC) is a calcitonin (CT)-secreting neuroendocrine tumour originating from C cells. Serum CT concentrations are helpful in the early detection of MTC, while it still unclear whether they can be used also for differential diagnosis between MTC and C-cell hyperplasia (CCH), precancerous condition familial MTCs but with clinical significance sporadic MTCs. Nowadays, surgery recommended all patients basal or pentagastrin (PG)-stimulated value 100 pg/ml more, without...
Bilateral adrenal hemorrhage is a rare condition, which burdened by potentially life-threatening consequences related to the development of acute insufficiency. Despite treatment with stress-dose glucocorticoids, mortality rate 15% has been reported, varies according severity underlying predisposing illness and could be much more higher if insufficiency not promptly recognized. An early diagnosis crucial, though, because nonspecific clinical laboratory findings, rarely suspected. Therefore,...
Context and Objectives: The prognosis of medullary thyroid carcinoma (MTC) depends on the completeness first surgical treatment. To date, it is not possible to predict whether tumor has been completely removed after surgery. aim this study was evaluate reliability an intraoperative calcitonin monitoring as a predictor final outcome surgery in patients with MTC. Patients Methods: Twenty underwent total thyroidectomy central lymph node dissection basis positive pentagastrin test. In six cases...
Renal infarction is a rare cause of referral to the emergency department, with very low estimated incidence (0.004%–0.007%). Usually, it manifests in patients aged 60–70 risk factors for thromboembolism, mostly related heart disease, atrial fibrillation particular. We report case idiopathic segmental renal 38-year-old patient, presenting acute abdominal pain no previous known history or thromboembolic diseases. Because its aspecific clinical presentation, this condition can mimic more...
Pancreatic vipoma is an extremely rare tumor accounting for less than 2% of endocrine pancreatic neoplasms with a reported incidence 0.1-0.6 per million. While cross-sectional imaging findings are usually not specific, exact localization the by means either computed tomography (CT) or magnetic resonance (MR) pivotal surgical planning. However, specific and further characterization may only be achieved somatostatin-receptor scintigraphy (SRS). We report case 70 years old female two history...
Tumoral calcinosis is a rare and benign hereditary tumor-like periarticular calcium deposit. It painless it found commonly around large joints such as hip, shoulder elbow. The condition predominately affects young black African patients with an equal gender ratio. In this report, case of primary idiopathic localized tumoral in 22-year-old man its distinctive radiographic "chicken wire" pattern was described.
A very rare localization of infantile hemangioma (IH) is mesentery. It may manifest with intra-luminal or intra-peritoneal bleeding. Here there the case a 45-day-old infant, presenting anemia and poor growth, subsequently referred to an uncommon As well as for most IH, conservative treatment only propranolol resulted in disappearance lesion. we analyze ultrasound magnetic resonance (MR) features this lesion, trying underline main characteristics at imaging order monitor response therapy.
The incidental detection of a tubulovillous adenoma at contrast-enhanced computed tomography (CECT) with nondedicated protocol, performed in emergency conditions, is an uncommon finding. We report case woman presenting subocclusive episode. A CECT scan was performed, and pedunculated polyp could be appreciated 3D-reconstruction images. particular depiction pedunculus the polypoid lesion, resemble clapper-bell, help to define vegetating lesion volume-rendering reconstruction This emphasizes...
Intestinal duplication is an uncommon congenital abnormality, with potential life-threatening complications, usually manifesting in childhood. Due to its non-specific clinical presentation as well resemblance other abdominal processes at imaging, the differential diagnosis may be very difficult. This case report describes a young female adult accessed twice our Emergency Department recurrent pain right iliac fossa and picture of bowel obstruction, who was finally diagnosed complicated cyst,...
Cystic dystrophy of the duodenal wall in heterotopic pancreas, recently described as paraduodenal pancreatitis, is a rare condition characterized by multiple cysts or pseudocysts located submucosa muscularis propria thickened wall. They result from episodes obstruction small ducts aberrant pancreatic islets. pancreas usually affects alcoholic males, but here we present case female without history alcohol abuse who was referred to our emergency department with abdominal pain and vomiting. She...
This is a report of case cystic hygroma the neck in female child. Cystic rare congenital malformation lymphatic system, most frequently detected head and region. Ultrasound considered as being first level study to investigate suspected mass suggestive hygroma. The Authors describe main diagnostic ultrasound features for this type lesion.
We report a case of 92-year-old man complaining epigastric pain, which an US first and CT scan later revealed to be related large gallstone causing cholecystitis. After the patient had refused surgical treatment for this condition, he was again referred our Emergency Department presenting with clinical picture gastric obstruction. A new showed classic Rigler’s triad, characterized by pneumobilia, distension in duodenal lumen, pathognomonic rare form ileus named Bouveret’s syndrome. The cause...