A5025456912- Metabolism and Genetic Disorders
- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Streptococcal Infections and Treatments
- Diet, Metabolism, and Disease
- Neonatal and Maternal Infections
- SARS-CoV-2 detection and testing
- Amino Acid Enzymes and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Folate and B Vitamins Research
- Cell Image Analysis Techniques
- Mitochondrial Function and Pathology
- GDF15 and Related Biomarkers
- Reproductive System and Pregnancy
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Cardiovascular Disease and Adiposity
University of Warwick
2016-2024
Heidelberg University
2021-2024
Helmholtz Zentrum München
2023-2024
Heinrich Heine University Düsseldorf
2021-2024
Deutsches Diabetes-Zentrum e.V.
2021-2024
German Center for Diabetes Research
2021-2024
University Hospital Heidelberg
2021-2024
London Metropolitan University
2009-2013
Ludwig-Maximilians-Universität München
2004-2008
München Klinik
2004
Abstract Automated detection of specific cells in three-dimensional datasets such as whole-brain light-sheet image stacks is challenging. Here, we present DELiVR, a virtual reality-trained deep-learning pipeline for detecting c-Fos + markers neuronal activity cleared mouse brains. Virtual reality annotation substantially accelerated training data generation, enabling DELiVR to outperform state-of-the-art cell-segmenting approaches. Our available user-friendly Docker container that runs with...
Triacylglycerol (TG) lowering effects of n-3 long-chain PUFA (n-3 LCPUFA) have been repeatedly demonstrated, but studies investigating the individual EPA or DHA on plasma TG and lipoproteins in man are rare. The a new DHA-rich, almost EPA-free microalgae oil (Ulkenia sp.) lipids several safety parameters were investigated double-blind, placebo-controlled, parallel design intervention study. Normolipidaemic vegetarians (eighty-seven females, twenty-seven males) consumed daily (0.94 g DHA/d)...
Background Rapid reviews are increasingly used to replace/complement systematic support evidence‐based decision‐making. Little is known about how this expedited process affects results. Objectives To assess differences between rapid and review approaches for a case study of test accuracy succinylacetone detecting tyrosinemia type 1. Methods Two reviewers conducted an “enhanced” then review. The enhanced involved narrower searches, single reviewer checking 20% titles/abstracts data...
Abstract Low red blood cell (RBC) membrane content of FPA+DHA (hereafter called omega‐3 index) has recently been described as an indicator for increased risk death from coronary heart disease. The relationship between plasma and RBC FA, focusing on index, the response to DHA supplementation were investigated in a double‐blind, randomized, placebo‐controlled, intervention study. Healthy vegetarians (87 f, 17 m) consumed daily microalgae oil Ulkenia sp. (0.94 g DHA/d) or olive (placebo) 8 wk....
Based on current evidence, routine screening for group B streptococcus colonisation in late pregnancy should not be introduced the UK, as potential harms of unnecessary treatment with antibiotics may outweigh benefits, argue <b>Farah Seedat and colleagues</b>
Accumulation of excess nutrients hampers proper liver function and is linked to nonalcoholic fatty disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation hepatocytes obesogenic dietary cues remain still largely unknown. Post-translational modification by small ubiquitin-like modifier (SUMO) allows a dynamic regulation numerous processes including transcriptional reprogramming. We demonstrate that specific SUMOylation transcription factor Prox1 represents...
Cancer is primarily a disease of high age in humans, yet most mouse studies on cancer cachexia are conducted using young adolescent mice. Given that metabolism and muscle function change with age, we hypothesized aging may affect progression models.We compare tumor development old mice three different strains (C57BL/6J, C57BL/6N, BALB/c) two cell lines (Lewis Lung Cancer, Colon26). Tumor size, body organ weights, fiber cross-sectional area, circulating biomarkers, molecular markers atrophy...
Fish oil supplementation during pregnancy not only improves maternal and neonatal DHA status, but often reduces gamma-linolenic acid (GLA), dihomo-GLA (DGLA), arachidonic (ARA) levels also, which may compromise foetal infant development. The present study investigated the effects of a fish oil/evening primrose (FSO/EPO) blend (456 mg DHA/d 353 GLA/d) compared to placebo (mixture habitual dietary fatty acids) on plasma (FA) composition in two groups twenty non-pregnant women using randomised,...
Many diseases, such as obesity, have systemic effects that impact multiple organ systems throughout the body. However, tools for comprehensive, high-resolution analysis of disease-associated changes at whole-body scale been lacking. Here, we developed a suite deep learning-based image algorithms (MouseMapper) and integrated it with tissue clearing light-sheet microscopy to enable comprehensive diseases impacting diverse across mouse This approach enables quantitative cellular structural...
Background: Cardiovascular disease rates are high in the UK, particular men, and related to dietary fat intake. We conducted a pilot study investigate relationships between saturated unsaturated intakes, body composition blood lipid parameters Caucasian men women at university. Methods: Volunteers (52 52 women; age range 20–50 years) were recruited from staff students of London Metropolitan University. Dietary intake, composition, pressure fasting glucose lipids assessed. Gender differences...