A5002325815- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy and Chemometric Analyses
- Non-Invasive Vital Sign Monitoring
- Advanced Fluorescence Microscopy Techniques
- Infrared Thermography in Medicine
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Bone Metabolism and Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Neonatal Health and Biochemistry
- Intraocular Surgery and Lenses
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- Advanced Nanomaterials in Catalysis
- Adolescent Sexual and Reproductive Health
- Protease and Inhibitor Mechanisms
- Atomic and Subatomic Physics Research
- TiO2 Photocatalysis and Solar Cells
- Molecular Biology Techniques and Applications
North Carolina State University
2025
Temple University
2015-2024
Bharati Vidyapeeth Deemed University
2020-2023
Banaras Hindu University
2023
Institute of Medical Sciences
2023
Sanjay Ghodawat University
2023
MIT World Peace University
2022
Creative Commons
2022
HCG Cancer Hospital
2022
S Nijalingappa Medical College and HSK Hospital & Research Centre
2022
Lack of menstrual knowledge, poor access to sanitary products and a non-facilitating school environment can make it difficult for girls attend school. In India, interventions have been developed reduce the burden menstruation by government non-governmental organizations (NGOs). We sought identify challenges related menstruation, facilitators management in schools three states India.Surveys were conducted among menstruating class 8-10 (above 12 years age) 43 selected through stratified random...
Abstract Matrix metalloproteinases (MMPs) are capable of processing certain components bone tissue, including type 1 collagen, a determinant the biomechanical properties and they expressed by osteoclasts osteoblasts. Therefore, we posit that MMP activity can affect ability to resist fracture. To explore this possibility, determined architectural, compositional, bones from wild-type (WT), Mmp2−/−, Mmp9−/− female mice at 16 weeks age. MMP-2 MMP-9 have similar substrates but primarily...
Abstract Transforming growth factor β (TGF-β) is an abundant bone matrix protein that influences osteoblast and osteoclast interactions to control remodeling. As such, TGF-β represents obvious pharmacologic target with the potential regulate both formation resorption improve volume strength. To investigate skeletal effect of inhibition in vivo, we used antibody (1D11) specifically directed at all three isoforms TGF-β. Normal mice were treated 1D11 or (4 weeks), cortical trabecular was...
We report a dual-modal device capable of sequential acquisition Raman spectroscopy (RS) and optical coherence tomography (OCT) along common axis. The enhances application both RS OCT by precisely guiding with images while also compensating for the lack molecular specificity in biochemical RS. characterize system performance demonstrate capability to identify structurally ambiguous features within an image scattering phantom, guide from localized malignancy ex vivo breast tissue, perform...
Photothermal optical coherence tomography (PT-OCT) is a potentially powerful tool for molecular imaging. Here, we characterize PT-OCT imaging of gold nanorod (GNR) contrast agents in phantoms, and apply these techniques vivo GNR The signal was compared to the bio-heat equation images were acquired from subcutaneous 400 pM Matrigel injections into mice. Experiments revealed that signals varied as predicted by equation, with significant increases at 7.5 scattering control (p < 0.01) while...
Abstract Background and Objective The current standard for diagnosis of skin cancers is visual inspection followed by biopsy histopathology. This process can be invasive, subjective, time consuming, costly. Optical techniques, including Coherence Tomography (OCT) Raman Spectroscopy (RS), have been developed to perform non‐invasive characterization lesions based on either morphological or biochemical features disease. objective this work report a clinical instrument capable both with RS‐OCT....
Conventional packed bed carbon dioxide capture systems with randomly positioned solid sorbent beads suffer from wall channeling, early breakthroughs, excessive pressure drop penalties, and poor contact-limited thermal transport characteristics. Advanced 3D printing techniques enable monolithic lattice topologies made of that can be tailored to minimize the shortcomings conventional systems. The full potential design freedom enabled by only realized through a detailed understanding...
Background and aim: Dentists dental hygienists often lack knowledge about eating disorders (ED) are reluctant to inform patients. This highlights the need for improved education encourage their involvement in ED prevention management. Hence, this study aimed assess knowledge, attitudes, clinical experience related among undergraduate students a institute Sangli city. Material methods: A descriptive, cross-sectional was conducted 250 third- final-year interns self-designed questionnaire...
Raman spectroscopy (RS) and optical coherence tomography (OCT) are powerful tools for analysis of tissues with mutually complementary strengths limitations. OCT excels at visualizing tissue microstructure but lacks molecular specificity, while RS can relay biochemical composition typically cannot relate microstructure. Previous implementations combined RS-OCT have utilized a common sample arm maintaining independent detection arms. We present the design application an integrated instrument...
There is potential for Raman spectroscopy (RS) to complement tools bone diagnosis due its ability assess compositional and organizational characteristics of both collagen mineral. To aid this potential, the present study assessed specificity RS peaks composition bone, a birefringent material, different degrees instrument polarization. Specifically, relative changes in were quantified as incident light rotated orientation osteonal interstitial tissue, acquired from cadaveric femurs. In highly...
Renal mass biopsy is still controversial due to imperfect accuracy. Raman spectroscopy (RS) demonstrated promise as an in vivo real‐time, nondestructive diagnostic tool many malignancies. Short wave infrared (SWIR) RS has the potential improve on previous systems for renal diagnosis. The aim of this study evaluate a SWIR system differentiating normal and malignant samples. Measurements were acquired using benchtop with excitation wavelength at 1064 nm InGaAs array detector. Processed spectra...
The lack of an effective technique for three-dimensional flow visualization has limited experimental exploration the "coffee ring effect" to two-dimensional, top-down viewpoint. In this report, high-speed, cross-sectional imaging fields was obtained using optical coherence tomography track particle motion in evaporating colloidal water drop. This approach enables z-dimensional mapping primary and secondary changes these over time. These sectional images show that 1 μm diameter polystyrene...
Raman spectroscopy is an established technique for molecularly specific characterization of tissues. However, even with near-infrared (NIR) excitation, some tissues possess background autofluorescence, which can overwhelm scattering. Here, we report collection spectra from strong autofluorescence using a 1064 nm system high-throughput dispersive spectrometer and deep-cooled InGaAs array. Spectra collected at were compared those 785 in specimens human breast, liver, kidney. The results...
Raman spectroscopy has been widely demonstrated for tissue characterization and disease discrimination, however current implementations with either 785 or 830 nm near-infrared (NIR) excitation have ineffectual in tissues intense autofluorescence such as the liver.Here we report use of a dispersive 1064 system using low-noise Indium-Gallium-Arsenide (InGaAs) array to discriminate highly autofluorescent bulk ex vivo specimens from healthy liver, adenocarcinoma, hepatocellular carcinoma (N = 5...
Photothermal OCT (PTOCT) provides high sensitivity to molecular targets in tissue, and occupies a spatial imaging regime that is attractive for small animal imaging.However, current implementations of PTOCT require extensive temporal sampling, resulting slow frame rates large data burden limit its vivo utility.To address these limitations, we have implemented optical lock-in techniques photothermal (poli-OCT), demonstrated the capabilities this approach.The poli-OCT signal was assessed...
Confocal reflectance microscopy and confocal Raman spectroscopy have shown potential for non-destructive analysis of samples at micron-scale resolutions. Current studies utilizing these techniques often employ large bench-top microscopes, are not suited use outside laboratory settings. We developed a microscope which combines laser scanning imaging into compact handheld probe that is capable high-resolution in variety The size the largely due to MEMS mirror beam scanning. axial resolutions...
Longitudinal monitoring techniques for preclinical models of vascular remodeling are critical to the development new therapies pathological conditions such as ischemia and cancer.In skeletal muscle in particular, there is a lack quantitative, non-invasive long term assessment vessel morphology.Here, we have applied speckle variance optical coherence tomography (OCT) methods quantitatively assess growth mouse model peripheral arterial disease.This approach was validated on two different...
Pulse oximetry is a common tool to perform non-invasive optical estimate (SpO2) of arterial blood oxygen saturation level (SaO2). Although the principle pulse has been established for long time Recent clinical studies reported oximeter over-estimation bias in black patients. Measurement accuracy an important factor, as could impact decision-making. Prior Monte-Carlo (MC) simulation-based showed increased melanin reduce signal intensity. These didn't show pigmentation on calibration equation...