A5024552424- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Trace Elements in Health
- Erythrocyte Function and Pathophysiology
- Legionella and Acanthamoeba research
- Hepatitis Viruses Studies and Epidemiology
- Blood disorders and treatments
- Blood groups and transfusion
- Microbial Metabolism and Applications
- Cerebrospinal fluid and hydrocephalus
- Vibrio bacteria research studies
- Cytomegalovirus and herpesvirus research
- Helminth infection and control
- Ovarian cancer diagnosis and treatment
- Immune Cell Function and Interaction
- Yersinia bacterium, plague, ectoparasites research
- Research on Leishmaniasis Studies
- Advanced Statistical Process Monitoring
- Heme Oxygenase-1 and Carbon Monoxide
- Parasitic infections in humans and animals
- Reproductive Biology and Fertility
- Clinical Laboratory Practices and Quality Control
- interferon and immune responses
- Ovarian function and disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
The University of Texas Medical Branch at Galveston
2023-2024
University of New Hampshire
2017-2020
Texas Tech University
2014-2017
Texas Tech University Health Sciences Center
2014-2016
University of Bern
2004
The University of Texas Health Science Center at Houston
2002
Abstract Schistosomiasis is of public health importance to an estimated one billion people in 79 countries. A vaccine urgently needed. Here, we report the results four independent, double‐blind studies Sm‐p80‐based baboons. The exhibited potent prophylactic efficacy against transmission Schistosoma mansoni infection and was associated with significantly less egg‐induced pathology, compared unvaccinated control animals. Specifically, resulted a 93.45% reduction pathology‐producing female...
Abstract Sm‐p80‐based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study designed to replicate human implementation scenario endemic regions which would be administered following drug treatment infected individuals. In our study, the reduced principal pathology producing hepatic egg burdens by 38.0% load small large intestines 72.2% 49.4%, respectively, baboons. Notably, hatching rates eggs recovered from liver intestine vaccinated...
Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an that promote rational design through the search for immune signatures and predictive correlates of protection. These will doubtlessly accelerate schistosomiasis, neglected tropical disease currently affects over 250 million people. For 15 years with contributions 120 people, we endeavored test optimize Sm-p80-based vaccines non-human primate model schistosomiasis. Using...
Schistosomiasis is a neglected parasitic disease of major public health concern as it affects over 250 million people in developing countries. Currently there no licensed vaccine available against schistosomiasis. The Schistosoma mansoni calpain protein, Sm-p80, leading candidate now ready to move clinical trials. In order better assess Sm-p80 immunogenicity; here we used systems biology approach employing RNA-sequencing identify gene signatures and epistatic interactions following...
Abstract Objective Identification of instrument failure (IF) represents a point to improve the quality services provided by medical laboratories. Here, logistic regression model was created define relationship between downtime and laboratory management systems. Methods Interval-level control (QC) categorical assurance data from 3 identical chemistry analyzers utilized generate able predict IF. A case-control approach forward stepwise likelihood-ratio method used develop model. The tested...
Abstract Background Schistosomiasis continues to inflict significant morbidity and mortality in the tropical subtropical regions of world. The disease endemicity overlaps with transmission other parasitic diseases. Despite ubiquity polyparasitism regions, particularly rural communities, little is known about impact multiple helminth infections on progression. In this pilot study, we describe influence chronic Trichuris trichiura infection Schistosoma mansoni egg-induced hepatopathology...
<h3>ABSTRACT</h3> Autoimmune hemolytic anemia (AIHA) is a rare disorder for which epidemiological studies are limited. Proper diagnosis of AIHA supported by clinical laboratory data that demonstrate all aspects the disease including evidence low hemoglobin (Hb), indication hemolysis elevated lactate dehydrogenase, and demonstrating involvement immune system positive direct antiglobulin test (DAT). The purpose this study was to investigate incidence at our institution establish correlation...
<b>Background:</b> A case with discrepancies between ABO antigens on red blood cells (RBCs) and isoagglutinins in the serum of a 49-year-old woman suffering from acute myeloid leukaemia is described. The group was typed as D neg previous pregnancy. <b>Material Methods:</b> 2 monoclonal anti-A, -B -AB reagents different manufacturers using techniques (NaCl suspension seroplates gel columns) were applied for detection patient's group. Suspensions commercial test erythrocytes (A<sub>1</sub>,...