A5027155147- Tissue Engineering and Regenerative Medicine
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- Ultrasound Imaging and Elastography
- Advanced MRI Techniques and Applications
- Trace Elements in Health
- Bladder and Urothelial Cancer Treatments
- Veterinary Orthopedics and Neurology
- Ultrasound and Hyperthermia Applications
- Endoplasmic Reticulum Stress and Disease
- Shoulder Injury and Treatment
- Infectious Encephalopathies and Encephalitis
- Pain Mechanisms and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Orthopedic Surgery and Rehabilitation
- Surgical site infection prevention
- Cell Image Analysis Techniques
- Surgical Sutures and Adhesives
- Mobile Crowdsensing and Crowdsourcing
- Helminth infection and control
- Indoor and Outdoor Localization Technologies
- Diverse Topics in Contemporary Research
Seoul National University
2024-2025
Texas Tech University Health Sciences Center
2013-2023
Texas Tech University
2013-2023
Pohang University of Science and Technology
2019-2020
Hana Pharm (South Korea)
2020
New York Academy of Sciences
2018
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Chungnam National University
2015-2017
Abstract Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role neuropathic pain remains unclear. In this study, we examined the ER and unfolded protein response (UPR) activation a L5 spinal nerve ligation (SNL)-induced rat model. SNL-induced was assessed behaviorally using CatWalk system histologically with microglial dorsal horn. SNL induced BIP upregulation neuron of superficial laminae It also increased level ATF6 intracellular localization into...
IPIN 2019 Competition, sixth in a series of competitions, was held at the CNR Research Area Pisa (IT), integrated into program Conference. It included two on-site real-time Tracks and three off-site Tracks. The four presented this paper were set same environment, made buildings close together for total usable area 1000 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> outdoors 6000 indoors over floors, with path length exceeding 500 m....
Abstract Schistosomiasis is of public health importance to an estimated one billion people in 79 countries. A vaccine urgently needed. Here, we report the results four independent, double‐blind studies Sm‐p80‐based baboons. The exhibited potent prophylactic efficacy against transmission Schistosoma mansoni infection and was associated with significantly less egg‐induced pathology, compared unvaccinated control animals. Specifically, resulted a 93.45% reduction pathology‐producing female...
Abstract Sm‐p80‐based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study designed to replicate human implementation scenario endemic regions which would be administered following drug treatment infected individuals. In our study, the reduced principal pathology producing hepatic egg burdens by 38.0% load small large intestines 72.2% 49.4%, respectively, baboons. Notably, hatching rates eggs recovered from liver intestine vaccinated...
In bladder, loss of mammalian Sonic Hedgehog (Shh) accompanies progression to invasive urothelial carcinoma, but the molecular mechanisms underlying this cancer-initiating event are poorly defined. Here, we show that Shh results from hypermethylation CpG shore gene, and inhibition DNA methylation increases expression halt initiation murine carcinoma at early stage progression. full-fledged tumors, pharmacologic augmentation (Hh) pathway activity impedes tumor growth, cancer-restraining...
Prostate cancer (PC) is the most frequently diagnosed malignancy among men and contributes significantly to cancer-related mortality. While recent advances in vitro PC modeling systems have been made, there remains a lack of robust preclinical models that faithfully recapitulate genetic phenotypic characteristics across various subtypes—from localized (LPC) castration-resistant (CRPC)—along with associated stromal cells. Here, we established human assembloids from LPC CRPC tissue by...
Sm-p80, the large subunit of Schistosoma mansoni calpain, is a leading candidate for schistosomiasis vaccine. The prophylactic and antifecundity efficacy Sm-p80 has been tested in three animal models (mouse, hamster baboon) using multitude vaccine formulations approaches. In our continual effort to enhance efficacy, this study, we have utilized adjuvant, synthetic hexa-acylated lipid A derivative, glucopyranosyl (GLA) formulated aluminum (GLA-Alum) with recombinant Sm-p80. rSm-p80+GLA-Alum...
Shoulder disease is a common cause of forelimb lameness in dogs. Determining the precise underlying shoulder can be challenging, especially veterinary practice. Computerized tomography (CT) often preferred imaging modality for bone evaluation; however, it uses ionizing radiation and provides limited soft tissue contrast. Conversely, magnetic resonance (MRI) offers excellent contrast but has limitations imaging. This study aimed to introduce new technical innovation that enhances cortical...
Magnetic resonance imaging (MRI) is essential for evaluating cerebellar compression in patients with craniocervical junction abnormalities (CJA). However, it limited depicting cortical bone because of its short T2 relaxation times, low proton density, and organized structure. Fast field echo resembling a computed tomography (CT) scan using restricted echo-spacing (FRACTURE) MRI, new technique that offers CT-like contrast without radiation. This study aimed to assess the feasibility FRACTURE...
Administering intraluminal fluid can improve the acoustic window for visualization of lumen and wall layers in cavitary organs. Microbubbles ultrasound contrast agents also be used intracavitary applications to enhance lesion human patients. However, there was no literature extending clinical application contrast-enhanced ultrasonography (CEUS) patients with naturally occurring diseases veterinary medicine. This case series aims describe detailed diagnostic value CEUS six cases...
While reperfusion of autologous blood using the Cellsaver (CS) device is routine in cardiothoracic surgery, there a paucity evidence-based literature regarding its use trauma. Utility CS was compared these two distinct populations at Level 1 trauma center from 2017 to 2022. successfully used 97% and 74% cardiac cases, respectively. The proportion requirements provided by CS, allogenic transfusion, also significantly higher surgery. However, still net benefit for with median salvaged...
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) is a key modulator of mitochondrial biogenesis. It multiple transcription factors and regulates metabolic processes. However, little known about the expression function PGC1α in glioblastoma multiforme (GBM), most prevalent invasive type brain tumor. The purpose present study was to investigate biological function, localization GBM. observed that increased tumor cells, higher level mitochondria. Bioinformatics analyses...
Administering intraluminal fluid can improve the acoustic window for visualization of lumen and wall layers in cavitary organs. Microbubbles ultrasound contrast agents also be used intracavitary applications to enhance lesion human patients. However, there was no literature extending clinical application contrast-enhanced ultrasonography (CEUS) patients with naturally occurring diseases veterinary medicine. This case series aims describe detailed diagnostic value CEUS six cases...
Current brain organoid technology fails to provide adequate patterning cues induce a mature structure that represent the complexity of human brain. Here, we developed module-based cellular reconstitution sequentially build uniform forebrain assembloids with cortical structures and functional connectivity. The uniformity maturity newly-conceived were achieved by creating single-rosette-based organoids at early stage, whose sizes big consistent treatment Wnt Hedgehog agonists, followed spatial...
Abstract Despite recent improvements in standard pharmacologic treatments of multiple myeloma (MM), immunotherapy may prove to be more effective due its higher specificity and lower toxicity. Indeed, current frontline MM therapies are based on the use drugs such as thalidomide, lenalidomide, bortezomib, which associated serious side effects undermined by development multidrug resistance recurring disease. The potential for immune surveillance against tumor recurrence has been clearly...
Abstract Current organoid models are limited by their inability to mimic mature organ architecture and associated tissue microenvironments 1,2 . Here, we create multi-layered normal bladder assembloids tumour reconstituting stem cell/tumour cell-derived organoids with multiple stromal components represent an organized functionality of adult bladder, in vivo pathophysiological features patient-derived urothelial carcinoma, respectively. Our assembloid model will facilitate development...