A5100417508- Phagocytosis and Immune Regulation
- Estrogen and related hormone effects
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Hippo pathway signaling and YAP/TAZ
- Ion Channels and Receptors
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Studies on Chitinases and Chitosanases
- Immune Cell Function and Interaction
- Neural and Behavioral Psychology Studies
- Colorectal Cancer Treatments and Studies
- Face Recognition and Perception
- Image and Signal Denoising Methods
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
Kosin University
2025
Korea University
2009-2024
Hallym University
2019-2023
Kangwon National University
2023
University of California, San Diego
2023
Yonsei University
2019-2022
Kettering University
2016-2021
University of California, San Francisco
2019-2021
UCSF Helen Diller Family Comprehensive Cancer Center
2019-2021
Seoul Institute
2020-2021
Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation microtubule-associated protein 1 light chain 3 (LC3) onto macroendocytic vacuoles, including macropinosomes, phagosomes, and entotic vacuoles. While this pathway is distinct from canonical autophagy, the mechanism how these nonautophagic membranes are targeted for LC3 remains unclear. Here we present evidence requires vacuolar-type H+-ATPase (V-ATPase) induced by osmotic imbalances within...
Abstract KRAS mutations are present in over 90% of pancreatic ductal adenocarcinomas (PDAC), and drive their poor outcomes failure to respond targeted therapies. Here we show that Leukemia Inhibitory Factor (LIF) expression is induced specifically by oncogenic PDAC LIF depletion genetic means or neutralizing antibodies prevents engraftment xenograft models. Moreover, LIF-neutralizing synergize with gemcitabine eradicate established tumors a syngeneic, Kras G12D -driven, mouse model. The...
Abstract Cell death pathways play critical roles in organism development and homeostasis as well the pathogenesis of various diseases. While studies over last decade have elucidated numerous different forms cell that can eliminate cells contexts, how certain mechanisms impact physiology is still not understood. Moreover, recent shown multiple occur a population, with eliminating individual cells. Here, we aim to describe known molecular entosis, non-apoptotic engulfment process, discuss...
microRNAs (miRs) modulate the expression levels of mRNAs and proteins can thus contribute to cancer initiation progression. In addition their intracelluar function, miRs are released from cells shed into circulation. We postulated that circulating could provide insight pathways altered during progression may indicate responses treatment. Here we focus on pancreatic malignant report changes in miR patterns normal tissues invasive adenocarcinoma p48-Cre/LSL-KrasG12D mouse model mirrors...
Abstract Purpose: The nuclear receptor coactivator amplified in breast cancer 1 (AIB1) was found to be and overexpressed some other epithelial tumors. We have reported that expression of AIB1 is rate limiting for growth factor, as well hormone signaling. Here, we assess the involvement development pancreatic adenocarcinoma. Experimental Design: investigated levels protein mRNA cell lines a series archival adenocarcinoma (n = 78), intraepithelial neoplasia 93), pancreatitis 28), normal...
Abstract Overexpression of the oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary tumorigenesis mice. In cancer, high levels AIB1/SRC-3 and growth factor HER2/neu predict resistance to endocrine therapy poor outcome. However, a mechanistic relationship between development has not been shown. Here, we show that deletion one allele SRC-3 significantly delays Neu-induced tumor Homozygous mice completely prevents formation. By ages 3 4 months,...
Thermosensation is mediated by ion channels that are highly temperature-sensitive. Several members of the family transient receptor potential (TRP) activated cold or hot temperatures and have been shown to function as temperature sensors in vivo. The molecular mechanism temperature-sensitivity these not understood. A number domains even single amino acids regulate identified several TRP channels. However, it unclear what precise conformational changes occur upon activation. Here, we used...
Significance Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and one deadly types, with a 5-y survival rate below 10%. One reason for this high mortality that PDAC cells have an enhanced ability to survive proliferate despite existing in nutrient-deprived environments. Understanding metabolic rewiring enables nutrient scavenging rapid processing can provide new strategies develop effective treatment options intractable disease. In study, convergent...
Abstract Background Targetable molecular drivers of gastric cancer (GC) metastasis remain largely unidentified, leading to limited targeted therapy options for advanced GC. We aimed identify and devise corresponding therapeutic strategies. Methods performed an unbiased in vivo genome-wide CRISPR/Cas9 knockout (KO) screening peritoneal dissemination using genetically engineered GC mouse models. Candidate genes were validated through transplantation assays KO cells. analyzed target expression...