A5102025473- Tracheal and airway disorders
- RNA and protein synthesis mechanisms
- Religion, Ecology, and Ethics
- Neurogenetic and Muscular Disorders Research
- Ethics and bioethics in healthcare
- Airway Management and Intubation Techniques
- Climate Change and Geoengineering
- RNA Research and Splicing
University of Coimbra
2023
Hospital Universitario Son Espases
2021
Abstract Background Hypoxemia is the most frequent complication of fiberoptic bronchoscopy (FB) in children. Guidelines recommend oxygen supplementation and conventional nasal prongs (NC) are used for this purpose. The aim study was to evaluate if use high‐flow cannula therapy (HFNC) children undergoing FB result a lower incidence hypoxemia than standard administration. Methods Patients aged 1 month–16 years elective were included prospective randomized controlled, nonblinded, single‐center...
RNA-targeting splicing modulators have revolutionized modern medicine by allowing reversible regulations of gene expression. Branaplam was the first molecule found to specifically modulate a behaviour at particular splice site. Originally, branaplam developed as modulator for spinal muscular atrophy (SMA), second most common autosomal recessive disease and primary cause genetic infant mortality. More recently, its use in Huntington’s (HD), fatal dominant neurodegenerative with limited...