A5103041275- Tracheal and airway disorders
- Respiratory viral infections research
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Esophageal and GI Pathology
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Vector-borne infectious diseases
- Neuroscience of respiration and sleep
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Plant Pathogenic Bacteria Studies
- High Altitude and Hypoxia
- Myasthenia Gravis and Thymoma
- Medicinal Plants and Bioactive Compounds
Hospital Universitario Son Espases
2013-2024
Health Research Institute of the Balearic Islands
2019-2024
Hospital Universitario Son Dureta
2003-2012
Emergence of epidemic clones and antibiotic resistance development compromises the management Pseudomonas aeruginosa cystic fibrosis (CF) chronic respiratory infections. Whole genome sequencing (WGS) was used to decipher phylogeny, interpatient dissemination, WGS mutator genotypes (mutome) resistome a widespread clone (CC274), in isolates from two highly-distant countries, Australia Spain, covering an 18-year period. The coexistence divergent CC274 clonal lineages revealed, but without...
Chronic respiratory infection by Pseudomonas aeruginosa is a major cause of mortality in cystic fibrosis (CF). We investigated the interplay between three key microbiological aspects these infections: occurrence transmissible and persistent strains, emergence variants with enhanced mutation rates (mutators) evolution antibiotic resistance. For this purpose, 10 sequential isolates, covering up to an 8-year period, from each CF patients were studied. As anticipated, resistance significantly...
Abstract Background Hypoxemia is the most frequent complication of fiberoptic bronchoscopy (FB) in children. Guidelines recommend oxygen supplementation and conventional nasal prongs (NC) are used for this purpose. The aim study was to evaluate if use high‐flow cannula therapy (HFNC) children undergoing FB result a lower incidence hypoxemia than standard administration. Methods Patients aged 1 month–16 years elective were included prospective randomized controlled, nonblinded, single‐center...
Abstract Background Airway diseases are highly prevalent in infants and cause significant morbidity. We aimed to determine the incidence risk factors for respiratory morbidity a Spanish cohort of moderate‐to‐late preterm ( MLP ) prospectively followed during their first year life. Methods SAREPREM is multicenter, prospective, longitudinal study. Preterm born at 32–35 weeks gestation with no comorbidities were enrolled within 2 life 2–4 weeks, 6, 12 months age. Multivariate mixed‐models...
Swallowing disorders which lead to aspiration are common in premature infants with a postmenstrual age (PMA) of >36 weeks. Aspiration is often silent and the unique symptom desaturation during feeding. The aim this study was 1) determine number prematures desaturations feeding due aspiration, using Fiberoptic Endoscopic Evaluation (FEES); 2) relate clinical factors FEES findings aspiration; 3) describe type efficacy suggested treatments.A retrospective review 62 ex-premature babies median...
Abstract Background Data addressing short‐ and long‐term respiratory morbidity in moderate‐late preterm infants are limited. We aim to determine the incidence of recurrent wheezing associated risk protective factors these during first 3 years life. Methods Prospective, multicenter birth cohort study born at 32 +0 35 weeks’ gestation followed for assess physician‐diagnosed wheezing. Allergen sensitization pulmonary function were also studied. used multivariate mixed‐effects models identify...
Preflight hypoxia challenge testing (HCT) in a body plethysmograph has previously been done only on infants >3 months of corrected gestational age (CGA). This study aims to determine the earliest fit-to-fly by neonates <1 week old.A prospective observational was carried out 3 groups infants: healthy term ≤7 days old, preterm (≥34 weeks CGA) 2 before discharge, and with bronchopulmonary dysplasia (BPD). HCT conducted using 15% fraction inspired oxygen. The oxygen saturation (Spo2) test fail...
γδ T cells have an important immunoregulatory and effector function through cytokine release. They are involved in the responses to Gram-negative bacterium protection of lung epithelium integrity. On other hand, they been implicated airway inflammation. The aim present work was study intracytoplasmic IL-2, IL-4, IFN-γ TNF-α production by αβ lymphocytes from cystic fibrosis patients healthy donors response Pseudomonas aeruginosa (PA). Flow cytometric detection performed after peripheral blood...
BACKGROUND: Fractional exhaled nitric oxide (FENO) levels are increased in children with asthma and infants recurrent wheezing, but the role of FENO acute phase bronchiolitis is still not defined. OBJECTIVE: The aim this study to evaluate values bronchiolitis, compare them healthy infants, relate those appearance other wheezing episodes. METHODS: were determined between 2 months years affected RVS by offline method. collected related respiratory clinical symptoms presented following episode....
Newborns diagnosed with craniofacial malformations or laryngeal and tracheal alterations may often need advanced airway-management for airway stabilization. Although fiberoptic bronchoscopy (FB) is currently the gold standard difficult management, there a scarcity of published data on application FB in newborns intubation controlled extubation (CE).This study describes case series where used and/or to manage either urgent procedures scheduled ones.All were carried out neonatal unit over...
Necrotizing pneumonia (NP) is a serious complication of community-acquired characterised by the destruction normal lung parenchyma. No study has evaluated repercussions damage in years following episode. The aim this was to assess long-term impact on function and respiratory symptoms children hospitalised due NP.We analysed outcomes given diagnosis NP between January 2003 April 2016. We selected patients aged more than 4 capable undergoing test, that had been followed up for at least 2...
La neumonía necrotizante (NN) es una complicación grave de la adquirida en comunidad caracterizada por destrucción del parénquima pulmonar normal. Ningún estudio ha evaluado las consecuencias este daño los años posteriores al episodio. El objetivo investigar el impacto a largo plazo sobre función y síntomas respiratorios niños ingresados NN. Seguimiento diagnosticados NN desde enero-2003 hasta abril-2016. Se seleccionó mayores 4 años, capaces realizar pulmonar, un seguimiento durante más 2...
Abstract Background Prematurity is associated with an increased risk of persistent wheezing but the underlying mechanisms are not well defined. The aim this study was to identify blood transcriptional profiles development in a cohort moderate late preterm infants and define immune gene expression changes wheezing. Materials Methods A convenience sample multicenter birth (SAREPREM) moderate‐late children followed during first 3 years life analyzed. Children were enrolled 2 weeks (Y0)...
We have studied the complications of varicella in children treated with inhaled steroids. From 1995 to 2005, 3/213 (1.4%) hospitalized on island Mallorca, Spain, for had received The rate hospitalization receiving steroids was 17/100,000 taking steroids, a similar rest children's population (18.2/100,000). Inhaled did not increase risk (relative 0.94; 95% confidence interval: 0.3–2.89).
Abstract Background Chronic bronchopulmonary infection due to MRSA in people with cystic fibrosis (pwCF) has been associated accelerated decline lung function, increased hospitalizations and mortality. Material methods We studied microbiological genomic characteristics of isolates recovered from pwCF two Spanish multicentre studies (2013, 2021). Antimicrobial susceptibility was performed. WGS carried out determine population structure [MLST, spa-typing, staphylococcal cassette chromosome mec...