A5035635207- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Congenital Diaphragmatic Hernia Studies
- Gut microbiota and health
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Child and Adolescent Health
- Digestive system and related health
- Genetic Associations and Epidemiology
- Pharmaceutical studies and practices
- Protease and Inhibitor Mechanisms
- Advanced Chemical Sensor Technologies
- Epigenetics and DNA Methylation
- Salivary Gland Disorders and Functions
- Peptidase Inhibition and Analysis
- Obstructive Sleep Apnea Research
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Phonocardiography and Auscultation Techniques
- Eosinophilic Esophagitis
Biogipuzkoa Health Research Institute
2016-2025
Donostia Unibertsitate Ospitalea
2012-2025
University of the Basque Country
2013-2019
Osakidetza
2010-2011
Boston Children's Hospital
2010
Rationale: Early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis exhaled volatile organic compounds (VOCs) an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. Objectives: To assess the accuracy gas chromatography-mass spectrometry based metabolite differentiate between uncontrolled Methods: This study encompassed a discovery (SysPharmPediA) validation phase (U-BIOPRED, PANDA)....
Background/Objectives: Metered-dose inhalers (MDIs) and dry powder (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. The difference in formulation administration technique of these devices may influence oral cavity microbiota composition. We aimed to compare the saliva microbiome children with moderate-to-severe asthma using ICS via MDIs versus DPIs. Methods: Saliva samples collected from 143 (6–17 yrs) across four European countries (The Netherlands, Germany, Spain, Slovenia)...
ABSTRACT Background Asthma exacerbations (AEs) represent the major contributor to global asthma burden. Although genetic and environmental factors have been associated with AEs, role of epigenetics remains uncovered. Objective This study aimed identify whole blood DNA methylation (DNAm) markers AEs in Europeans. Methods DNAm was assessed 406 samples from Spanish individuals using Infinium MethylationEPIC microarray (Illumina). An epigenome‐wide association conducted test at differentially...
Asthma is a chronic inflammatory disease of the airways. patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which significantly contribute to asthma burden. The Pi*S and Pi*Z variants SERPINA1 gene, usually involve alpha-1 antitrypsin (AAT) deficiency, had previously been associated with asthma. link between AAT deficiency might be represented by elastase/antielastase imbalance. However, their role in exacerbations remains unknown. Our objective...
BackgroundThe upper-airway microbiome is involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. Although human genetics regulates composition, its influence on asthma-related airway bacteria remains unknown.ObjectiveWe sought to identify genes and biological pathways regulating airway-microbiome traits ICS response.MethodsSaliva, nasal, pharyngeal samples from 257 European patients with were analyzed. The association of 6,296,951 genetic variants...
The raised volume rapid thoracoabdominal compression (RVRTC) technique is commonly used to obtain full forced expiratory manoeuvres from infants, but reference equations derived 'in-house' equipment have been shown be inappropriate for current commercially available devices. <h3>Aim</h3> To explore the impact of differences on RVRTC outcomes, derive robust equipment-specific ranges and investigate their potential clinical data interpretation. <h3>Method</h3> healthy subjects using Jaeger...
Background In the USA, genetically admixed populations have highest asthma prevalence and severe exacerbations rates. This could be explained not only by environmental factors but also genetic variants that exert ethnic-specific effects. However, no admixture mapping has been performed for exacerbations. Objective We sought to identify associated with in Hispanic/Latino subgroups means of analyses fine mapping, assess their transferability other potential functional roles. Methods an 1124...
Abstract Background Uncontrolled asthma can lead to severe exacerbations and reduced quality of life. Research has shown that the microbiome may be linked with characteristics; however, its association control not been explored. We aimed investigate whether gastrointestinal used discriminate between uncontrolled controlled in children. Methods 143 103 feces samples were obtained from children moderate‐to‐severe aged 6 17 years SysPharmPediA study. Patients classified as or asthmatics, their...
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, influence DNAm on BDR FeNO scarcely investigated. This study aims identify markers in whole blood associated either with or We analyzed 121 samples from children moderate-to-severe The association genome-wide has been assessed using regression models,...
There is a clinical need to identify children with poor asthma control as early possible, optimize treatment and/or find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims establish pediatric cohort of moderate-to-severe uncontrolled and controlled patients asthma, investigate pathophysiological mechanisms underlying in on maintenance treatment, using multi-omics systems medicine approach. In this...
Objective. The aim of this post hoc analysis was to establish the relationship between FENO levels and asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants wheezing (three or more episodes) were recruited consecutively online tests at tidal breathing multiple breaths performed. Results. Twenty-seven (84%) out 32 (median age 12 months) who met inclusion criteria for analysis, successfully performed determinations. Eighteen (66%) classified positive stringent...
Abstract Background The aim of this study was to investigate the association among a validated symptom‐based questionnaire for asthma control in children (CAN), forced expiratory volume 1 sec (FEV ), and fractional exhaled nitric oxide (FE NO ). Methods Observational cross‐sectional performed consecutive sample asthmatic aged between 7 14 years old from December 2007 February 2008. FE measured with portable electrochemical analyzer spirometry according American Thoracic Society/European...
Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric flux; JawNO) and distal inflammation (alveolar concentration; CANO). The main aim was study the association among symptoms, lung function, flux) concentration) in asthmatic children treated not with inhaled glucocorticoids.A cross-sectional prospective data collection carried out a consecutive sample of girls boys aged between 6 16 years medical diagnosis asthma. Maximum flux alveolar...
Abstract Introduction Pulmonary interstitial glycogenosis (PIG) is a rare infant lung disease characterized by an increase in the number of mesenchymal cells, presenting as enhanced cytoplasmic glycogen, and considered to represent expression underlying development disorder. Methods This study describes clinical, radiological, functional characteristics long‐term outcomes (median 12 years) nine infants diagnosed with isolated PIG associated alveolar simplification absence other diseases....
Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers known. The Genomics and Metagenomics of Severity (GEMAS) study aims assess role genomics microbiome in severe asthma exacerbations. Here, we present design GEMAS characteristics patients recruited from March 2018 2020. Different biological samples demographic clinical variables were collected by allergy pulmonary medicine units several hospitals Spain. Cases controls defined...
Uncontrolled pediatric asthma has a large impact on patients and their caregivers. More insight into determinants of uncontrolled is needed. We aim to compare treatment regimens, inhaler techniques, medication adherence other characteristics children with controlled in the: Systems Pharmacology approach Paediatric Asthma (SysPharmPediA) study.145 moderate severe doctor-diagnosed (91 54 controlled) aged 6-17 years were enrolled this multicountry, (Germany, Slovenia, Spain, the Netherlands)...