Mario Martin‐Almeida
A5019076149- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Helicobacter pylori-related gastroenterology studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
Universidad de La Laguna
2022-2025
ABSTRACT Background Asthma exacerbations (AEs) represent the major contributor to global asthma burden. Although genetic and environmental factors have been associated with AEs, role of epigenetics remains uncovered. Objective This study aimed identify whole blood DNA methylation (DNAm) markers AEs in Europeans. Methods DNAm was assessed 406 samples from Spanish individuals using Infinium MethylationEPIC microarray (Illumina). An epigenome‐wide association conducted test at differentially...
Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, influence DNAm on BDR FeNO scarcely investigated. This study aims identify markers in whole blood associated either with or We analyzed 121 samples from children moderate-to-severe The association genome-wide has been assessed using regression models,...
<b>Introduction:</b> Asthma is the most common chronic respiratory condition in children. Fractional exhaled nitric oxide (FeNO) a biomarker of type-2 airway inflammation that can be used to monitor asthma management. DNA methylation nasal cells has been associated with FeNO, but association methylome blood remains unknown. <b>Aim:</b> To identify DNAm markers whole FeNO pediatric asthma. <b>Methods:</b> Samples from children moderate-to-severe 4 different European Systems Pharmacology...