A5045993404- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Allergic Rhinitis and Sensitization
- Cancer-related molecular mechanisms research
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Nanoplatforms for cancer theranostics
- Metal-Organic Frameworks: Synthesis and Applications
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Cytokine Signaling Pathways and Interactions
- Respiratory Support and Mechanisms
- Occupational exposure and asthma
- Olfactory and Sensory Function Studies
- Immune responses and vaccinations
- Animal Virus Infections Studies
Universidad Autónoma de Madrid
2018-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017-2025
Instituto de Salud Carlos III
2019-2025
Hospital Universitario Fundación Jiménez Díaz
2017-2024
Vall d'Hebron Hospital Universitari
2023
Universitat Autònoma de Barcelona
2023
Hospital de Sant Pau
2023
Hospital Clínic de Barcelona
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Hospital Universitario La Paz
2022
Metal-organic frameworks (MOFs), network structures wherein metal ions or clusters link organic ligands into porous materials, are being actively researched as nanoscale drug delivery devices they offer tunable with high cargo loading that can easily be further functionalized for targeting and enhanced physiological stability. The excellent biocompatibility of Zr has meant its MOFs among the most studied to date, in particular archetypal terephthalate UiO-66. In contrast, isoreticular analog...
The high drug-loading and excellent biocompatibilities of metal–organic frameworks (MOFs) have led to their application as drug-delivery systems (DDSs). Nanoparticle surface chemistry dominates both biostability dispersion DDSs while governing interactions with biological systems, cellular and/or tissue targeting, internalization, leading a requirement for versatile reproducible functionalization protocols. Herein, we explore not only the effect introducing different functionalities...
Eosinophils, a central factor in asthma pathogenesis, have the ability to secrete exosomes. However, precise role played by exosomes biological processes leading up has not been fully defined.We hypothesized that released eosinophils contribute pathogenesis activating structural lung cells.Eosinophils from asthmatic patients and healthy volunteers were purified peripheral blood, isolated of individuals. All experiments performed with eosinophil-derived subjects. Epithelial damage was...
Abstract Eosinophils are able to secrete exosomes that have an undefined role in asthma pathogenesis. We hypothesized released by eosinophils autoregulate and promote eosinophil function. of patients with (n = 58) healthy volunteers 16) were purified from peripheral blood, isolated quantified the asthmatic populations. Apoptosis, adhesion, adhesion molecules expression, migration assays performed presence or absence individuals. Reactive oxygen species (ROS) evaluated flow cytometry...
Asthma is a syndrome characterized by airway inflammation and obstruction. Due to its heterogeneity, the difficulties in asthma diagnosis treatment make discovery of new biomarkers focus research. So, we determined differential miRNA expression eosinophils between healthy asthmatic patients establish differentially expressed profile detectable sera for use as biomarker.MicroRNAs from peripheral subjects were isolated analyzed next-generation sequencing confirmed quantitative PCR 29...
There is currently enough evidence to think that miRNAs play a role in several key points asthma, including diagnosis, severity of the disease, and response treatment. Cells release different types lipid double-membrane vesicles into extracellular microenvironment, exosomes, which function as very important elements intercellular communication. They are capable distributing genetic material, mRNA, mitochondrial DNA, microRNAs (miRNAs). Serum miRNA screening was performed order analyze...
MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and biomarkers for diseases, including asthma. In era personalized medicine, there is a need novel disease-associated can help in classifying diseases into phenotypes treatment selection. Currently, severe eosinophilic asthma one most widely studied clinical practice, many patients require higher doses corticosteroids, which some cases fail to achieve desired outcome. Such may only benefit from...
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution the diagnosis and targeted treatment of a range diseases. The aim study was analyze miRNA expression profiles in serum lung tissue from patients with severe asthma treated oral corticosteroids (OCS) those without OCS treatment. For this purpose, miRNAs non-OCS asthmatic individuals were evaluated by miRNAs-Seq, subsequently validation performed using RT-qPCR. Additionally, pathway enrichment...
Eosinophils are leukocytes involved in homeostasis and diseases like asthma. The existence of eosinophil subpopulations remain controversial, with eosinophils being classified as type 1, 2, inflammatory, resident, homeostatic, or developmental depending on the publication,1 no clear indication intrinsic environmental dependence. Unsupervised methods could provide data true subclassifications, which be importance for efficacy asthma therapy.2 Therefore, aim this study is to analyse blood...
Presenting prevalence, characteristics and outcome of asthmatic
ABSTRACT Objectives: Eosinophilic esophagitis (EoE) is a chronic esophageal disease characterized by eosinophilic inflammation. Proton‐pump inhibitors (PPI) induce remission but no predictive factors of PPI‐responsiveness have been identified yet. So, biomarker must be found to differentiate between responders (PPI‐R) and nonresponder patients (PPI‐NR) PPI. Aims were identify any molecular that could predict PPI responsiveness study after therapy. Methods: This prospective enrolled 39...
Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is monoclonal antibody that binds IL-5 receptor alpha subunit depletes peripheral blood eosinophils rapidly. Biomarkers predict the response this drug are needed microRNAs (miRNAs) can be useful tools. This study was performed with fifteen severe asthmatic patients treated serum miRNAs were evaluated before...
Chronic rhinosinusitis with nasal polyps (CRSwNP), which is characterized by partial loss of smell (hyposmia) or total (anosmia), commonly associated asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). CRSwNP worsens severity and quality life. The objective this real-world study was to determine whether biological treatments prescribed for severe can improve olfaction in patients CRSwNP. A further compare the improvement N-ERD non-N-ERD subgroups.We...