The high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation surface functionality is a route to enhanced properties, here we report on surface-modification procedure—click modulation—that controls their size chemistry. zirconium terephthalate MOF UiO-66 (1) synthesized ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded cargo, (3) covalently modified...

Metal-organic frameworks (MOFs) are emerging as leading candidates for nanoscale drug delivery, a consequence of their high capacities, ease functionality, and the ability to carefully engineer key physical properties. Despite many anticancer treatment regimens consisting cocktail different drugs, examples delivery multiple drugs from one MOF rare, potentially hampered by difficulties in postsynthetic loading more than cargo molecule. Herein, we report new strategy, multivariate modulation,...

Assembly of different metal-organic frameworks (MOFs) into hybrid MOF-on-MOF heterostructures has been established as a promising approach to develop synergistic performances for variety applications. Here, we explore the performance heterostructure by epitaxial growth MIL-88B(Fe) onto UiO-66(Zr)-NH2 nanoparticles. The face-selective design and appropriate energy band structure alignment selected MOF constituents have permitted its application an active heterogeneous photocatalyst...

We have used a family of Zr-based metal-organic frameworks (MOFs) with different functionalized (bromo, nitro and amino) extended linkers for drug delivery. loaded the materials fluorescent model molecule calcein anticancer α-cyano-4-hydroxycinnamic acid (α-CHC), consequently performed mechanical amorphization process to attempt control delivery guest molecules. Our analysis revealed that loading values both molecules were higher MOFs containing unfunctionalized linkers. Confocal microscopy...

Metal-organic frameworks (MOFs), network structures wherein metal ions or clusters link organic ligands into porous materials, are being actively researched as nanoscale drug delivery devices they offer tunable with high cargo loading that can easily be further functionalized for targeting and enhanced physiological stability. The excellent biocompatibility of Zr has meant its MOFs among the most studied to date, in particular archetypal terephthalate UiO-66. In contrast, isoreticular analog...

Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although effective way to deliver drugs mitochondria is by covalently linking them lipophilic cation, vivo delivery free still constitutes critical bottleneck. Herein, we report design mitochondria-targeted metal-organic framework (MOF) that greatly increases efficacy model drug, reducing required dose less than 1% compared drug ca. 10% nontargeted MOF. The performance system...

The high drug-loading and excellent biocompatibilities of metal–organic frameworks (MOFs) have led to their application as drug-delivery systems (DDSs). Nanoparticle surface chemistry dominates both biostability dispersion DDSs while governing interactions with biological systems, cellular and/or tissue targeting, internalization, leading a requirement for versatile reproducible functionalization protocols. Herein, we explore not only the effect introducing different functionalities...

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance <italic>in vitro</italic> cytotoxicity.

Abstract Metal–organic frameworks (MOFs) are emerging as leading candidates for nanoscale drug delivery, a consequence of their high capacities, ease functionality, and the ability to carefully engineer key physical properties. Despite many anticancer treatment regimens consisting cocktail different drugs, examples delivery multiple drugs from one MOF rare, potentially hampered by difficulties in postsynthetic loading more than cargo molecule. Herein, we report new strategy, multivariate...

A critical bottleneck for the use of metal–organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in acidic environment lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and fate these depends on routes entry. Here, we show effect functional group incorporation into a series Zr-based MOFs mechanisms, us design an efficient system. In particular, naphthalene-2,6-dicarboxylic...

Thermogravimetric analysis (TGA) has been widely used as a tool to characterise the composition of materials such Metal‐Organic Frameworks (MOFs). However, given their multifunctionality and structural complexity, examples detailed methodologies for exact calculation complex MOF structures composites are lacking in literature. Herein, we introduce new straightforward methodology – based on experimental ratio between mass structure its residue almost any material. We provide guide application...

Defect engineering is a valuable tool to tune the photocatalytic activity of metal-organic frameworks (MOFs). Inducing defects through attachment functionalized modulators can introduce cooperative units that bandgap material and enhance their chemical, thermal, photostabilities among other properties. However, majority defect studies for applications are limited Zr-based MOFs, there still lack interrelation between synthetic variables, resultant MOF properties, effect on performance. We...

Two ultramicroporous 2D and 3D iron-based Metal-Organic Frameworks (MOFs) have been obtained by solvothermal synthesis using different ratios concentrations of precursors. Their reduced pore space decorated with pendant pyridine from tangling isonicotinic ligands enables the combination size-exclusion kinetic gas separation, due to their small pores, thermodynamic resulting interaction linker CO2 molecules. This combined separation results in efficient materials for dynamic breakthrough...

The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells), and an efficient drug carrier for the long-term controlled release (through skin) of antioxidant ferulate. also preserves pharmacological effects ferulate while enhancing bio-preservation dermal fibroblasts, during delivery process. These discoveries pave way toward extended use Sc(III)-based MOFs as systems (DDSs).

Ultra-small isoreticular UiO-type metal–organic frameworks (MOFs) with different functionalized and extended linkers are evaluated for catalytic direct amide bond formation.

The connectivity of mono- and dicarboxylic modulators controls their ability to promote defects in the titanium framework MUV-10.

Defect engineering is a valuable tool to tune the properties of metal-organic frameworks. However, defect chemistry remains still predominantly limited UiO-type MOFs. We describe preferential formation missing cluster defects in heterometallic titanium-organic frameworks MUV-10 family when synthesised sub-stoichiometric linker conditions. Our results show value integrating experimental work, computational modelling and thorough characterization rationalizing impact over porosity structure...

The catalytic performance of metal–organic frameworks (MOFs) is related to their physicochemical properties, such as particle size, defect chemistry and porosity, control can be potentially achieved by coordination modulation.

Assembly of different Metal-Organic Frameworks (MOFs) into hybrid MOF-on-MOF heterostructures has been established as a promising approach to develop unique synergistic performances for variety applications. Here we report the synthesis by epitaxial growth MIL-88B(Fe) onto UiO-66(Zr)-NH2 nanoparticles. The face-selective design and appropriate energy band structure alignment selected MOF constituents have permitted its application active heterogeneous photocatalyst solar-driven water...

The multivariate modulation of Metal-Organic Frameworks is presented as a valuable tool to introduce multiple functional units into UiO-66 while increasing its porosity. This manuscript encloses comprehensive study using

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour-, five-, or six-membered methanide auracycles: x-ray structure of [(C6F5)2AuPPh2CH(AuC6F5)PPh2CHCOOMe]Rafael. Uson, Antonio. Laguna, Mariano. Isabel. Lazaro, and Peter G. JonesCite this: Organometallics 1987, 6, 11, 2326–2331Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/om00154a010https://doi.org/10.1021/om00154a010research-articleACS...

NanoMUV-2 stores high payloads of Paclitaxel and increases its anticancer selectivity.

Both [Au(C6F5)3(SPh2PCHPPh2Me)]{obtained from [Au(C6F5)3(OEt2)] and [SPh2PCH2PPh2Me]ClO4, followed by deprotonation with NaH} the free methanide SPPh2CHPPh2Me react gold(I) or silver(I) complexes [Au(C6F5)(tht)](tht = tetrahydrothiophene), [Au(tht)2]ClO4, [Ag(OClO3)(PPh3)] to afford binuclear of types [Au(C6F5){SPh2 PCH[Au(C6F5)]PPh2Me}] [{M(SPh2PCHPPh2Me)}2][ClO4]2(M Au Ag). The silver complex can also be obtained [{Ag(SPh2PCH2PPh2Me)}2][ClO4]2 Na2CO3. Oxidative addition chlorine gold...