A5030553880- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- Delphi Technique in Research
Hospital Universitario Fundación Jiménez Díaz
2021-2022
Instituto de Salud Carlos III
2021
MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and biomarkers for diseases, including asthma. In era personalized medicine, there is a need novel disease-associated can help in classifying diseases into phenotypes treatment selection. Currently, severe eosinophilic asthma one most widely studied clinical practice, many patients require higher doses corticosteroids, which some cases fail to achieve desired outcome. Such may only benefit from...
Severe eosinophilic asthma poses a serious health and economic problem, so new therapy approaches have been developed to control it, including biological drugs such as benralizumab, which is monoclonal antibody that binds IL-5 receptor alpha subunit depletes peripheral blood eosinophils rapidly. Biomarkers predict the response this drug are needed microRNAs (miRNAs) can be useful tools. This study was performed with fifteen severe asthmatic patients treated serum miRNAs were evaluated before...
Asthma is a chronic inflammatory condition of the airways with complex pathophysiology. Stratification asthma subtypes into phenotypes and endotypes should move field forward, making treatment more effective personalized. Eosinophils are key cells involved in severe eosinophilic asthma. Given health threat posed by asthma, there need for reliable biomarkers to identify affected patients treat them properly novel biologics. microRNAs (miRNAs) promising diagnostic tool. The aim this study was...
Background: Respiratory viral infections (RVIs) are frequent in preterm infants and may have long-term impact on respiratory morbidity, especially those with bronchopulmonary dysplasia (BDP). The immune response key defence elements, so the purpose of this study is to evaluate regulation epithelial barrier integrity suffering RVIs during Neonatal Intensive Care Unit (NICU) admission. Materials methods: Nasopharyngeal aspirate (NPA) was obtained, separating cells from supernatants. Viral...
Respiratory viral infections (RVIs) are frequent in preterm infants possibly inducing long-term impact on respiratory morbidity. Immune response and barriers key defense elements against insults premature admitted to Neonatal Intensive Care Units (NICUs). Our main goals were describe the local immune secretions of with RVIs during NICU admission evaluate expression synthesis lung barrier regulators, both samples vitro models. Samples from that went develop had lower filaggrin gene protein...