Glutathione (GSH), widely present in plant and animal cells crucial for combating oxidative stress inflammation, has not been evaluated dairy cows. This study aims to evaluate the effects of rumen-protected glutathione (RPGSH) supplementation on lactation, nutrient metabolism, stress, health transition Forty Holstein cows (2.65 ± 0.78 parity, 2.81 0.24 body condition score, 9207.56 1139.18 kg previous 305-day milk yield, 657.53 55.52 weight, mean SD) were selected from a large cohort 3215...

Abstract Introduction This study aimed to investigate the impact of perinatal body condition score (BCS) and its subsequent loss on postpartum performance health outcomes in dairy cattle. Material Methods A total 156 cows were randomly selected, blood samples collected at –21, 0, 7, 14, 21, 28 50 days relative calving. Milk yield disease incidence recorded after These subsequently categorised into three groups based BCS during transition period: a no-BCS-loss (maintained BCS) group (M, 0...

Highly enantioselective hydrogenation of α‐hydroxy ketones was achieved by applying the catalytic combination cobalt acetate and chiral Ph‐BPE ligand, supplemented a carboxylic acid additive promotion strategy. The significantly increases both reactivity enantioselectivity, allowing for highly efficient generation 1,2‐diols with up to 99% ee. application utility is proved through derivations total synthesis (R)‐(‐)‐Eliprodil. Mechanistic studies including control experiments DFT calculations...

Highly enantioselective hydrogenation of α‐hydroxy ketones was achieved by applying the catalytic combination cobalt acetate and chiral Ph‐BPE ligand, supplemented a carboxylic acid additive promotion strategy. The significantly increases both reactivity enantioselectivity, allowing for highly efficient generation 1,2‐diols with up to 99% ee. application utility is proved through derivations total synthesis (R)‐(‐)‐Eliprodil. Mechanistic studies including control experiments DFT calculations...

As a comprehensive concept that integrates the environment, society, and corporate governance, little is known about whether how Esg affects firm development, as of sustainable development deepened promoted. Therefore, purpose this paper to investigate impact performance on development. This selects data A-share-listed companies from 2010 2020 samples, utilizes linear regression model empirically study mechanism enterprise considers transmission pathways. It found high-technology firms more...

Abstract Introduction The aim of this study was to evaluate the effect negative energy balance (NEB) on final growth dominant ovarian follicle in Holstein cows. Material and Methods Cows at 14 21 d postpartum from an intensive dairy farm were randomly selected allocated into a positive group (PEB, with β-hydroxybutyric acid (BHBA) level < 1.2 mmol/L, n = 15) NEB (BHBA > 15). Plasma samples collected 21, 50 55 assess concentrations metabolites, minerals, hormones cytokines. Ovaries...

Inactive ovaries (IO) accounts for 50% of ovarian disease in postpartum dairy cows, which seriously affects their reproductive efficiency. To investigate the metabolic changes serum and follicular fluid cows with IO during lactation, six estrus (E) at 50 to 55 days milk were selected based on B ultrasonic detection clinical manifestations. The differential metabolites between E identified by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry, combined...

Differential metabolites (DMs) between cows with inactive ovaries (IO) and oestrous (E) were screened metabolic pathways of DMs associated IO determined.Cows at 50 to 60 days (d) postpartum from an intensive dairy farm randomly selected allocated into E group (n = 16) or according a pedometer rectal examinations. Their plasma samples analysed by liquid chromatography-mass spectrometry (LC-MS) compare changes the groups. Multivariate pattern recognition was used screen in cows.Compared normal...

Inactive ovaries (IO) and ovarian (follicular or luteal) cysts (FC LC) are two common diseases leading to infertility in dairy cattle. Both disorders associated with altered metabolites hormones. There currently no known effective biomarkers that can be used for early diagnosis of diseases. The purpose this study was identify the plasma Holstein cows facilitate an control its progression. experiment performed from 3 weeks postpartum last 7 weeks. Seventy-six multiparous (mean age, 4.36...

Postpartum inactive ovaries (IOs) in dairy cows reduce the economic returns of industry. It is related to energy metabolism disorder, inflammatory response and oxidative stress. The objective this study was investigate association liver function index (LFI) serum cytokines at 21 days postpartum with IO predict risk cows. blood 60 parturient collected through caudal root vein 3, 21, 28 55 postpartum. Ultrasonography performed 50 determine follicular development. With median LFI as standard,...

Metabolic disorders may lead to the inactive ovaries of dairy cows during early lactation. However, detailed metabolic profile with around 55 days postpartum has not been clearly elucidated. The objective this study was investigate difference in and estrus from perspective serum metabolites. According clinical manifestations, B-ultrasound scan, rectal examination, 15 were assigned group (E; follicular diameter 15–20 mm) ovary (IO; <8 mm increased <2 within 5 over two...

Abstract Asymmetric hydrogenation of enol ethers has emerged as a valuable and environmentally friendly method for the preparation optically active cyclic acyclic ethers, some which have demonstrated substantial potential application in synthesis compounds total natural products. Over past few decades, significant attention been devoted to use transition‐metal catalysts, particularly those containing chiral phosphine‐phosphine, phosphine‐amine, or carbene ligands, unfunctionalized ethers. In...

Vitamin E, a potent antioxidant, is necessary and complex micronutrient for cows. During the transition period, vitamin E deficiency (VED) among highest prevalent deficits in dairy It may eventually result oxidative stress immunological malfunction, it increases risk of peripartum disorders. At present, detailed data on blood metabolites VED cows are limited. Consequently, purpose this research was to examine alterations serum metabolic profile throughout early postpartum period. Using...

Clinical ketosis is a crucial metabolic disease in dairy cows that often accompanied by severe lipolysis and inflammation adipose tissue. Our previous study suggested the fold change of calmodulin (CaM) was upregulated 2.401-fold tissue with clinical ketosis. Therefore, we hypothesize CaM may regulate inflammatory responses cows. To verify hypothesis, conducted thorough veterinary assessment symptoms serum β-hydroxybutyrate (BHB) concentration before collecting subcutaneous samples from six...

Vitamin E, a potent antioxidant, is necessary and complex micronutrient for cows. During the transition period, vitamin E deficiency (VED) among highest prevalent deficits in dairy It may eventually result oxidative stress immunological malfunction, it increases risk of peripartum disorders. At present, detailed data on blood metabolites VED cows are limited. Consequently, purpose this research was to examine alterations serum metabolic profile throughout early postpartum period. Using...

For projectile impact penetration experiment, batteries or capacitors are usually used as power sources for projectile-borne recording devices. However, these easy to fail under high impact. In this paper, a small-impact magnetoelectric generator is introduced, which converts force into electrical energy supply The influence of structure on force–electricity conversion efficiency analyzed. Based the analysis, with double springs and two-part coils designed. A hammer test carried out...

Abstract Background Left displacement of the third gastric compartment (LDC3) in alpacas is an extremely rare condition and has not been reported thus far. Therefore, we describe clinical diagnosis treatment LDC3 alpaca. Case presentation A 2-year-old brown female alpaca ( Vicugna pacos ) was presented to evaluate a 3-day history abdominal distension causing loss both appetite thirst, along with oliguria low no defecation. Clinical examination, X-ray surgical exploration, determination pH...

The incidence of Inactive ovaries dairy cows in China is relatively high. There no complete early warning system for the occurrence ovarian quiescence clinical cows. This test provides indicators prediction ovary cessation experiment selected blood samples from 60 to 90 days postpartum inactive group and control group. Differential proteins were on basis proteomics, three energy indexes: AST, Glu, NEFA. Four reproductive hormones: E2, P4, FSH, LH, four differentially expressed proteins:...