A5016880843- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Medical and Agricultural Research Studies
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- Prenatal Screening and Diagnostics
- Circular RNAs in diseases
- FOXO transcription factor regulation
- Chromosomal and Genetic Variations
- Cancer-related Molecular Pathways
International Peace Maternity & Child Health Hospital
2015-2023
Shanghai Jiao Tong University
2018-2023
Center for Excellence in Molecular Cell Science
2018
Shanghai Institutes for Biological Sciences
2018
ShanghaiTech University
2018
Objective To assess associations of elevated lipid levels during gestation with hypertensive disorders pregnancy (HDP) and gestational diabetes mellitus (GDM). Methods This prospective cohort study was conducted in a tertiary maternal hospital Shanghai, China from February to November 2014. Lipid constituents, including triglycerides (TGs), total cholesterol (TC), low-density lipoprotein (LDL-c) high-density (HDL-c) 1310 eligible women were assessed the first (10–13+ weeks), second (22–28...
Abstract Epithelial ovarian cancer (EOC) is the most lethal tumor of all gynecologic tumors. There no curative therapy for EOC thus far. The tumor-homing ability adult mesenchymal stem cells (MSCs) provide promising potential to use them as vehicles transport therapeutic agents site tumor. Meanwhile, studies have showed intrinsic anti-tumor properties MSCs against various kinds cancer, including epithelial cancer. Human endometrial (EnSCs) derived from menstrual blood are a novel source and...
Preeclampsia is a common pregnancy-specific disorder characterized by elevated blood pressure and proteinuria. Activation of the maternal immune system impaired placental angiogenesis are thought to contribute pathogenesis preeclampsia. TLR9 (Toll-like receptor 9) plays role in innate immunity, defending organism against infection. The purpose this study was determine whether inhibits at fetomaternal interface under conditions We confirmed downregulation VEGFA (vascular endothelial growth...
The etiology and pathogenesis of preeclampsia (PE) remain unclear, ideal biomarkers for the early detection PE are scarce. involvement competing endogenous RNA (ceRNA) hypothesis in is only partially understood. present study aimed to delineate a regulatory network comprised messenger RNAs (mRNAs), circular (circRNAs), long non-coding (lncRNAs), microRNAs (miRNAs) via ceRNA profiles from human umbilical vein endothelial cells (HUVECs) further reveal potential biomarkers.Differentially...
Objective: Autophagy influences a wide range of physiological and pathological processes in the human body. In this study, we aimed to investigate role autophagy early-onset preeclampsia (EOPE); activation by hypoxia could rescue impaired angiogenesis apoptosis preeclampsia, leading ox-LDL. Methods: Transmission electron microscopy was applied identify autolysosomes trophoblast cells placenta apical region. Quantitative real-time polymerase chain reaction, Western blot, flow cytometry,...
Abstract Preeclampsia (PE) is characterized by placental ischemia and hypoxia, resulting in abnormal casting of the uterine spiral artery, which mainly caused insufficient trophoblastic cell infiltration. A reduction levels growth factor‐based signalling via Neuropilin‐1 (NRP1) has been shown to contribute dysfunctional trophoblast development. In this study, we showed that RNA‐binding protein, QKI5, regulated NRP1 expression significantly improved proliferation vitro vivo. QKI5 expressions...
In all studies conducted so far, there was no report about the correlation between excessive gestational weight gain (GWG) and risk of preeclampsia (PE) in multiparas, especially considering that multiparity is a protective factor for both GWG PE. Thus, aim this retrospective cohort study to determine whether multiparas associated with increased PE.This 15,541 multiparous women who delivered maternity hospital Shanghai from 2017 2021, stratified by early-pregnancy body mass index (BMI)...
Preeclampsia (PE) is a pregnancy-associated disease that may cause maternal and fetal morbidity mortality. The dysregulation of microRNAs (miRNAs) their potential functions has been an important direction for elucidating the mechanism preeclampsia in recent years. present study investigated whether miR-4443 was significantly increased placentas severe preeclamptic patients, upregulation inhibited migration invasion HTR-8/SVneo cells according to transwell assays. Matrix metallopeptidase 2...
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e15515 Background: To assess the interactions and dynamics of hedgehog (Hh) Wnt pathway activation levels in three ovarian carcinoma cell lines (SKOV3, IGROV, OVCAR5) treated with two different Hh inhibitors. Methods: Three cancer were cultured over 24, 48, 72 96 hours respectively 20 mM Cyclopamine, FN (novel small molecule inhibitor Gli) or DMSO as control. The cells harvested mRNA was extracted. Quantitative RT-PCR performed to determine gene expression (GLI1, PTCH1, SMO) (AXIN2, FGF9)...