A5030327076- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Cell Adhesion Molecules Research
- Asthma and respiratory diseases
- Platelet Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- melanin and skin pigmentation
- Ocular Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Metastasis and carcinoma case studies
- Cardiomyopathy and Myosin Studies
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Cancer-related gene regulation
- Receptor Mechanisms and Signaling
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2018-2022
Universitat de Barcelona
2016-2022
The study of anaphylactoid reactions during perioperative procedures and anaesthesia represents a diagnostic challenge for allergists, as many drugs are administered simultaneously, approximately half them trigger allergic without verifiable IgE-mediated mechanism. Recently, mast cell receptor MRGPRX2 has been identified cause pseudo-allergic drug reactions. In this study, we analyse the ability certain used to induce MRGPRX2-dependent degranulation in human cells sera from patients who...
The activation and degranulation of mast cells is critical in the pathogenesis allergic inflammation modulation inflammation. Recently, we demonstrated that unconventional long-tailed myosin, MYO1F, localizes with cortical F-actin mediates adhesion migration cells. In this study, show knockdown MYO1F by short hairpin RNA reduces human cell induced both IgE crosslinking stimulation Mas-related G protein-coupled receptor X2 (MRGPRX2), which has been associated pseudoallergic drug reactions,...
Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is preferential treatment for these tumors; however, development drug resistance has highlighted need novel therapeutic strategies. Recently, we reported that adaptor molecule SH3 Binding Protein 2 (SH3BP2) regulates expression and signaling in human mast cells. Our current...
Mast cell chemotaxis is essential for recruitment to target tissues, where these cells play an important role in adaptive and innate immunity. Stem factor (SCF) a major chemoattractant mast cells. SCF binds the KIT receptor, thereby triggering tyrosine phosphorylation cytoplasmic domain resulting docking sites SH2 domain-containing molecules, such as Lyn Fyn, subsequent activation of small GTPases Rac that are responsible cytoskeletal reorganization migration. In previous works we have...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of gastrointestinal tract. Gain function in receptor tyrosine kinases type III, KIT, or PDGFRA drives majority GIST. Previously, our group reported that silencing adaptor molecule SH3 Binding Protein 2 (SH3BP2) downregulated KIT and microphthalmia-associated transcription factor (MITF) levels reduced tumor growth. This study shows SH3BP2 also decreases ETV1, a required for GIST To dissect pathway cells, we performed...
An amendment to this paper has been published and can be accessed via a link at the top of paper.