A5073533587- Protein Hydrolysis and Bioactive Peptides
- Computational Drug Discovery Methods
- Antimicrobial Peptides and Activities
- Monoclonal and Polyclonal Antibodies Research
- Protein Structure and Dynamics
- Biochemical and Structural Characterization
- Natural product bioactivities and synthesis
- RNA and protein synthesis mechanisms
- Silk-based biomaterials and applications
- Chemical Synthesis and Analysis
- vaccines and immunoinformatics approaches
- Enzyme function and inhibition
- Cancer Immunotherapy and Biomarkers
- Phenothiazines and Benzothiazines Synthesis and Activities
- Image and Video Stabilization
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Peptidase Inhibition and Analysis
- Toxin Mechanisms and Immunotoxins
- Cholinesterase and Neurodegenerative Diseases
- Metamaterials and Metasurfaces Applications
- Advanced Steganography and Watermarking Techniques
- Biochemical effects in animals
- Electromagnetic wave absorption materials
- Heat shock proteins research
Southwest University
2021-2022
Ministry of Agriculture and Rural Affairs
2022
Science and Technology on Surface Physics and Chemistry Laboratory
2022
State Key Laboratory of Silkworm Genomic Biology
2021
Chongqing University of Technology
2019-2021
Chongqing Medical and Pharmaceutical College
2019
Chongqing University
2019
The blockade of the programmed cell death protein 1/programmed ligand 1 (PD-1/PD-L1) pathway plays a critical role in cancer immunotherapy by reducing immune escape. Five monoclonal antibodies that antagonized PD-1/PD-L1 interaction have been approved Food and Drug Administration (FDA) marketed as for treatment. However, some weaknesses antibodies, such high cost, low stability, poor amenability oral administration, immunogenicity, should not be overlooked. To overcome these disadvantages,...
A multiple-image encryption scheme based on cascaded fractional Fourier transform is proposed. In the scheme, images are successively coded into amplitude and phase of input by cascading stages, which ends up with an encrypted image a series keys. The takes full advantage multikeys relationships all it not only realizes but also achieves higher safety more diverse applications. So multiuser authentication hierarchical achieved. Numerical simulation verifies feasibility method demonstrates...
Sericin is a natural protein with high application potential, but the research on its efficacy very limited. In this study, anti-inflammatory mechanism of sericin was investigated. Firstly, composition extracts determined by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). This then combined Enzyme-linked Immunosorbent Assay (ELISA) and Quantitative Real-time PCR (qRT-PCR), it confirmed that anti-inflammation ability positively correlated purity 1 protein. Finally, RNA-seq...
Communicated by Ramaswamy H. Sarma
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has attracted worldwide attention due to its high infectivity and pathogenicity. Objective: purpose this study is develop drugs with therapeutic potentials for COVID-19. Methods: we selected the crystal structure 3CL pro perform virtual screening against natural products in Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP). Then,...
PD-1-targeted discovery of modulators by virtual screening, molecular docking, surface plasmon resonance binding assay and T-cell activation assay.
Abstract The emergence of multi-drug resistance bacteria poses great health theat. Therefore, it is a crucial demand to obtain new antibacterial drugs. Antimicrobial peptides (AMPs) have the characteristics wide antimicrobial spectrum and lower drug resistance, hence, hopeful substitute for classical antibiotics. In this study, two classic methods, comparative molecular field analysis (CoMFA) similarity index (CoMSIA), were used structural feature small AMPs against S. aureus or E. coli...