A5102026751- Advancements in Battery Materials
- Hydraulic Fracturing and Reservoir Analysis
- Advanced Battery Materials and Technologies
- Extracellular vesicles in disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Drilling and Well Engineering
- Mitochondrial Function and Pathology
- Advanced Battery Technologies Research
- Plant Stress Responses and Tolerance
- Semiconductor materials and devices
- Hydrogen's biological and therapeutic effects
- Catalytic Processes in Materials Science
- Epilepsy research and treatment
- Genetic diversity and population structure
- Plant biochemistry and biosynthesis
- Photonic and Optical Devices
- Catalysis and Oxidation Reactions
- Sepsis Diagnosis and Treatment
- Adaptive optics and wavefront sensing
- Electronic Health Records Systems
- Photosynthetic Processes and Mechanisms
- Membrane-based Ion Separation Techniques
- Bone Metabolism and Diseases
- Phase-change materials and chalcogenides
Army Medical University
2008-2025
Daping Hospital
2020-2025
Zunyi Medical University
2020-2024
Qilu Hospital of Shandong University
2022-2023
Changsha University of Science and Technology
2023
Huazhong Agricultural University
2018-2023
Chinese Academy of Sciences
2004-2022
Lanzhou Institute of Chemical Physics
2022
Shandong University
2022
University of Chinese Academy of Sciences
2022
Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ with elusive underlying mechanisms limited treatment options.In this study, the cecal ligation puncture lipopolysaccharide (LPS) were used to reproduce sepsis model in vitro vivo.The level voltage-dependent anion channel 2 (VDAC2) malonylation malonyl-CoA detected by mass spectrometry LC-MS-based metabolomics.Role VDAC2 on cardiomyocytes ferroptosis effect mitochondrial targeting nano material TPP-AAV...
Vascular dysfunctions such as vascular hyporeactivity following ischemic/hypoxic injury are a major cause of death in injured patients. In this study, we showed that treatment with mitochondrial division inhibitor 1 (Mdivi-1), selective dynamin-related protein (Drp1), significantly improved reactivity ischemic rats by attenuating oxidative stress. The antioxidative effects Mdivi-1 were relatively Drp1-independent, and possibly due to an increase the levels antioxidant enzymes, SOD1 catalase,...
Abstract Mitochondrial mass imbalance is one of the key causes cardiovascular dysfunction after hypoxia. The activation dynamin-related protein 1 (Drp1), as well its mitochondrial translocation, play important roles in changes both morphology and functions However, addition to mediating fission, whether Drp1 has other regulatory homeostasis translocation unknown. In this study, we performed a series interaction colocalization assays found that, may promote excessive opening permeability...
Background To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Methods The hub were screened using machine learning algorithms, and the cell infiltration of these assessed by CIBERSORT Single-sample GSEA. Next, function at single-cell level validated comparing multiregional landscapes between septic patients (SP) healthy control (HC). Then, support vector machine-recursive feature elimination (SVM-RFE) algorithm was...
Tea plants [Camellia sinensis (L.) O. Kuntze] are an important leaf-type crop that widely used for the production of non-alcoholic beverages in world. Exposure to excessive amounts heavy metals adversely affects quality and yield tea leaves. To analyze molecular responses metals, a reliable quantification gene expression is major importance herein normalization measured levels target genes. Ideally, stably expressed reference genes should be evaluated all experimental systems. In this study,...
Neuroinflammation is one of the essential pathogeneses cognitive damage suffering from sepsis-associated encephalopathy (SAE). Lots evidences showed microglia presented mitochondrial fragmentation during SAE. This study investigated protective effects and novel mechanisms inhibiting via division inhibitor 1 (Mdivi-1) on in The SAE model was performed by cecal ligation puncture (CLP), Mdivi-1 administrated intraperitoneal injection. Morris water maze to assess function. Mitochondrial...
Extracellular vesicles derived from pericytes (PCEVs) have been shown to improve vascular permeability, with their therapeutic effects attributed the presence of pro-regenerative molecules. We hypothesized that angiopoietin 1 (Angpt1) carried by PCEVs contributes after sepsis. A cecal ligation and puncture (CLP)-induced sepsis rat model was used in vivo, on endothelial cells were studied vitro. First, proteomic Gene Ontology enrichment analyses performed analyze mechanism PCEVs, revealing...
Background and objective To explore the risk factors construct a prediction model of lymphovascular invasion (LVI) in patients with upper tract urothelial carcinoma (UTUC). Methods Clinical data 143 UTUC treated our hospital during Jan. 2010 Dec. 2022 were retrospectively analyzed. The divided into LVI positive group negative according to postoperative conditions. Kaplan-Meier method was used evaluate overall survival (OS) cancer-specific (CSS) two groups, curve drawn. correlation between...
Abstract Each shale gas play is unique and the stimulation completion method should be determined based on individual attributes. Selecting style for an emerging begin in laboratory rather than copy successful cases. An understanding of rock mechanical properties essential to help understand how reservoir completed. We conducted triaxial compression tests specimens from North America South China. The failure modes behaviors are analyzed. A new combines mineralogy quantify brittleness was...
Small heat shock proteins (sHSPs) play important roles in responses to stress. However, the functions of sHSPs tea plants (Camellia sinensis) remain uncharacterized. A novel sHSP gene, designated CsHSP17.2, was isolated from plants. Subcellular localization analyses indicated that CsHSP17.2 protein present cytosol and nucleus. expression significantly up-regulated by stress but unaffected low temperature. The transcript levels increased following salt polyethylene glycol 6000 treatments...
Background: Hemorrhagic shock was a leading cause of death worldwide, with myocardial injury being primary affected organ. As commonly used solutions in fluid resuscitation, acetated Ringer's (AR) and Lactate solution (LR) were far from perfect for their adverse reactions such as lactic acidosis electrolyte imbalances. In previous studies, TPP@PAMAM-MR (TPP-MR), novel nanocrystal resuscitation has been found to protect against septic rats. However, its role rats hemorrhagic underlying...
Abstract Manganese (Mn) is an important micronutrient element required for plant growth and development, playing catalytic roles in enzymes, membranes DNA replication. The tea ( Camellia sinensis ) able to accumulate high concentration of Mn without showing signs toxicity, but the molecular mechanisms underlying this remain largely unknown. In study, C. cultivar ‘LJCY’ had higher tolerance than ‘YS’, because chlorophyll content reduction was lower under treatment. Proteomic analysis leaves...
The prevention and treatment of postmenopausal osteoporosis (PMOP) is a significant public health issue, non-coding RNAs are vital importance in this process. In study, we find that the long RNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript (lncRNA KCNQ1OT1) can alleviate ovariectomy-induced (OVX) PMOP vivo. We determined over-expression KCNQ1OT1 could enhance functions MC3T3-E1 cells, whereas an opposite trend was observed when knocked down. Subsequently,...
Abstract Background Sepsis is a life-threatening disease with poor prognosis, and metabolic disorders play crucial role in its development. This study aims to identify key metabolites that may be associated the accurate diagnosis prognosis of sepsis. Methods Septic patients healthy individuals were enrolled investigate changes using non-targeted liquid chromatography-high-resolution mass spectrometry metabolomics. Machine learning algorithms subsequently employed differentially expressed...
Abstract Background Sepsis is a major cause of death in ICU, and intestinal barrier dysfunction its important complication, while the treatment limited. Recently, mesenchymal stem cell-derived microvesicles (MMVs) attract much attention as strategy cell-free treatment; whether MMVs are therapeutic sepsis induced-intestinal obscure. Methods In this study, cecal ligation puncture-induced rats lipopolysaccharide-stimulated epithelial cells to investigate effect on dysfunction. were harvested...