A5046934026- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Sarcoma Diagnosis and Treatment
- Voice and Speech Disorders
- Bone Tissue Engineering Materials
- Cell Adhesion Molecules Research
- Conducting polymers and applications
- Dysphagia Assessment and Management
- Additive Manufacturing and 3D Printing Technologies
- Traumatic Brain Injury Research
- Cerebral Palsy and Movement Disorders
- Cleft Lip and Palate Research
- Muscle Physiology and Disorders
- Stroke Rehabilitation and Recovery
- Reconstructive Surgery and Microvascular Techniques
Defense Health Agency
2023-2024
Uniformed Services University of the Health Sciences
2022-2024
U.S. National Science Foundation
2024
Walter Reed National Military Medical Center
2022
Rensselaer Polytechnic Institute
2017-2021
Smith College
2018
Syracuse University
2018
University of Memphis
2018
Texas A&M University
2018
Louisiana State University Health Sciences Center New Orleans
2018
ABSTRACT Scarring of the vocal fold lamina propria (LP) can cause considerable voice disorders due to reduced pliability in scar tissue, attributed part abnormal extracellular matrix (ECM) deposition produced by fibrotic fibroblast (fVFF). Cytokines with anti‐fibrotic potential have been investigated limit LP ECM, but are limited need for repeat injections. Moreover, potentially significant role played activated macrophages (AMOs) is usually not considered even though interaction between AMO...
Abstract Scarring of the vocal fold lamina propria can lead to debilitating voice disorders that significantly impair quality life. The reduced pliability scar tissue—which diminishes proper vibratory efficiency—results in part from abnormal extracellular matrix (ECM) deposition by fibroblasts (VFF) have taken on a fibrotic phenotype. To address this issue, bioactive materials containing cytokines and/or growth factors may provide platform transition VFF within scarred tissue toward an...
Volumetric muscle loss (VML) represents a devastating extremity injury which leads to chronic functional deficits and disability is unrecoverable through normal healing pathways. When left untreated, the VML pathophysiology creates many challenges towards successful treatment, such as altered residual architecture, excessive fibrosis, contracture(s). As such, innovative approaches technologies are needed prevent or reverse these adverse sequelae. Development of rationally designed...
ABSTRACT Tumor emboli—aggregates of tumor cells within vessels—pose a clinical challenge as they are associated with increased metastasis and recurrence. When growing vessel, emboli subject to unique mechanical constraint provided by the tubular geometry vessel. Current models use unconstrained multicellular spheroids, which neglect this interplay. Here, we modeled lymphatic vessel 200 μm-diameter channel in either stiff or soft, bioinert agarose matrix create vessel-like model (VLCM), colon...
Ductal carcinoma in situ (DCIS) is a precancerous stage breast cancer, where abnormal cells are contained within the duct, but have not invaded into surrounding tissue. However, only 30-40% of DCIS cases likely to progress an invasive ductal (IDC), while remainder innocuous. Since little known about what contributes transition from IDC, clinicians and patients tend opt for treatment, leading concerns overdiagnosis overtreatment. In vitro models currently being used probe how transitions many...
Abstract In recognition of the importance and timeliness computational models for accelerating progress in neurorehabilitation, U.S. National Science Foundation (NSF) Institutes Health (NIH) sponsored a conference March 2023 at University Southern California that drew global participation from engineers, scientists, clinicians, trainees. This commentary highlights promising applications to understand neurorehabilitation (“Using complex mechanisms neurorehabilitation” section), improve...
Treatment of volumetric muscle loss (VML) faces challenges due to its unique pathobiology and lower priority in severe musculoskeletal injury management. Consequently, a need exists for multi-stage VML treatment strategies accommodate delayed interventions owing comorbidity management or prolonged casualty care combat settings. To this end, polyvinyl alcohol (PVA) was used at concentrations 5%, 7.5%, 10% generate provisional void fillers (MVFs) varying stiffness values (1.125 kPa, 3.700...
Abstract Stromal collagen surrounding a solid tumor tends to present as dense, thick bundles. The bundles are remodeled during progression: first tangential the boundary (indicating growth) and later perpendicular likely metastasis). Current reconstituted-collagen in vitro models unable recapitulate vivo structural features of bundling alignment. Here, we rapid yet simple procedure fabricate with an average thickness 9 μm, compared reticular dense nanofiber (∼900 nm-diameter, on average)...
ABSTRACT Tumor emboli – aggregates of tumor cell within vessels pose a clinical challenge as they are associated with increased metastasis and recurrence. When growing vessel, subject to unique mechanical constraint provided by the tubular geometry vessel. Current models use unconstrained multicellular spheroids, which neglect this interplay. Here, we modelled lymphatic vessel 200 μm-diameter channel in either stiff or soft, bioinert agarose matrix, colon breast cancer HCT116 SUM149PT cells,...
ABSTRACT Ductal carcinoma in situ (DCIS) is a pre-cancerous stage breast cancer, where abnormal cells are contained within the duct, but have not invaded into surrounding tissue. However, only 30-40% of DCIS cases likely to progress an invasive ductal (IDC), while remainder innocuous. Since little known about what contributes transition from IDC, clinicians and patients tend opt for treatment, leading concerns overdiagnosis overtreatment. In vitro models currently being used probe how...