This study aimed to compare clinical courses and outcomes between pregnant reproductive-aged non-pregnant women with COVID-19, assess the vertical transmission potential of COVID-19 in pregnancy.Medical records hospitalized from January 15 March 15, 2020 were retrospectively reviewed. The severity disease, virus clearance time, length hospital stay measured as primary objective, while was also assessed.Eighty-two patients (28 women, 54 women) laboratory-confirmed enrolled this study....

This study aimed to develop and validate an interpretable machine-learning model based on clinical features for early predicting in-hospital mortality in critically ill patients with sepsis.We enrolled all sepsis the Medical Information Mart Intensive Care IV (MIMIC-IV, v.1.0) database from 2008 2019. Lasso regression was used feature selection. Seven methods were applied models. The best selected its accuracy area under curve (AUC) validation cohort. Furthermore, we employed SHapley...

The COVID-19 pandemic has posed significant threats to both the physical and psychological health of healthcare workers working in front-line combating COVID-19. However, studies regarding medium long term impact on mental among are limited. Therefore, we conducted this cross-sectional survey investigate prevalence, factors post-traumatic stress disorder (PTSD) exposed 8 months after end outbreak Wuhan, China.A web-based questionnaire was delivered as a link via communication application...

Although the combination of polymyxin and tigecycline is widely used in treating carbapenem-resistant bacterial infections, benefit this still uncertain. To assess whether adding B to high-dose regimen would result better clinical outcomes than therapy patients with pneumonia caused by Klebsiella pneumoniae Acinetobacter baumannii, we conducted a propensity score-matched cohort study single center between July 2019 December 2021. Of 162 eligible patients, 102 were included 1:1 matched...

Traditional markers, such as serum creatinine and blood urea nitrogen, frequently show delayed elevations following acute kidney injury (AKI), limiting their utility for prompt detection timely intervention in AKI management. Shear wave elastography (SWE) exhibits potential diagnosis by measuring tissue stiffness. Our study aimed to evaluate the diagnostic performance of SWE detecting stiffness tissue. Between July 2022 December 2022, a total 103 consecutive participants who met eligibility...

Myeloid-derived suppressor cells (MDSCs) are important participants after acute myocardial infarction (AMI), but the role of their different subtypes in AMI remains controversial. The anti-inflammatory effect ticagrelor has been discovered. However, detailed mechanism not fully demonstrated. In this study, we aimed to determine whether can regulate differentiation MDSCs into subgroups exert effects AMI. vitro experiments revealed no difference mRNA and protein expression P2Y12 receptors on...

BackgroundShear wave elastography (SWE) is a novel imaging technique that provides quantitative assessments of tissue stiffness. This non-invasive method offers real-time, measurements and has been widely applied to various tissues, providing valuable diagnostic insights.PurposeThis study aimed investigate the feasibility using SWE evaluate stiffness lens in patients with age-related cataracts.Materials MethodsA comparative analysis involving 92 diagnosed cataracts 39 healthy controls was...

Abstract Glioblastoma (GBM) is the most common primary intracranial tumor in central nervous system, and resistance to temozolomide an important reason for failure of GBM treatment. We screened out that Solute Carrier Family 2 Member 10 (SLC2A10) significantly highly expressed with a poor prognosis, which also enriched NF-E2 p45-related factor (NRF2) signalling pathway. The NRF2 pathway defence mechanism against ferroptosis. SLC2A10 related LINC02381 GBM, localized cytoplasm/exosomes,...

Ulinastatin has been found to have anti-inflammatory effect for patients with sepsis. However, its clinical effects were conflicting. The study aimed investigate the cost-effectiveness of ulinastatin and perform mediation analysis explore proportion total that can be explained by inflammatory responses. This is a retrospective involving critically ill sepsis from January 2014 July 2017. A 263 included in study, 179 group 84 control group. showed significantly lower 28-day mortality rate than...

Background Myeloid-derived suppressor cell (MDSC) mobilisation is an important immune event in acute myocardial infarction (AMI). The A2B adenosine receptor (A2BAR) plays key role regulating MDSC function, but its specific involvement AMI remains unclear.Methods In patients, the circulating ratio and A2BAR mRNA expression were measured. A mouse model was established by left anterior descending coronary artery (LADCA) ligation. MDSCs analysed FACS immunofluorescence staining (of heart...

Diaphragmatic ultrasound has been increasingly used to evaluate diaphragm function. However, current diaphragmatic parameters provide indirect estimates of contractile function, and the predictive value is controversial. Two-dimensional (2D) speckle tracking an effective technology for measuring tissue deformation can be measure longitudinal strain (DLS) assess The purpose this study was determine feasibility reproducibility DLS quantification by 2D whether maximal could predict weaning...

Abstract Background Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined potential functions a lncRNA, LINC01003, glioma and characterized underlying molecular mechanisms. Methods The GEIPA2 Chinese Glioma Genome Atlas (CCGA) databases were employed to analyze gene expression overall survival curve patients with LINC01003 growth migration assessed by loss-of-function experiments vitro vivo. RNA sequencing was used determine signaling pathways...

Acetaminophen is a commonly used analgesic after surgery, and its impact on prognosis in patients with acute respiratory distress syndrome (ARDS) has not been studied. This study explores the association between use of acetaminophen risk mortality ARDS. In this retrospective cohort study, 3,227 ARDS who had or received were obtained from Medical Information Mart for Intensive Care IV, divided into non- groups. In-hospital was considered as primary end point. We univariate multivariate Cox...

Objective Nonalcoholic Wernicke’s encephalopathy (WE) is a devastating neuropsychiatric syndrome caused by thiamine deficiency. Although many case reports on WE have been published, more studies are required to guide the diagnosis and treatment of nonalcoholic WE. Methods We retrospectively studied patients who were diagnosed with in our hospital. Data demographics, possible causes, phenomenology, diagnostic delays abstracted from medical records chart reviews. Results Seventeen had such as...

The association between thiamine use and clinical outcomes among patients with sepsis alcohol disorder (AUD) is unclear.In this retrospective cohort study of from Medical Information Mart for Intensive Care III (MIMIC-III, version 1.4), we evaluated the in AUD sepsis. primary outcome was 28-day survival, secondary included ICU, in-hospital, 90-day mortality, ICU hospital length stay, duration vasopressor use, need continuous renal replacement therapy (CRRT), dynamic changes variables up to...

Objectives Postoperative sore throat (POST) is very common in patients under general anaesthesia. However, there no effective clinical predictive model for reducing its occurrence. The objective of this study was to estimate the risk factors POST after anaesthesia by designing a nomogram. Design A prospective study. Setting This conducted large tertiary hospital. Participants Patients aged 18–85 years old who received with either an endotracheal tube or supraglottic airway and American...

Ulinastatin has anti-inflammatory properties and could potentially benefit critically ill septic patients. Nevertheless, clinical studies have yielded conflicting results. The present study examined the efficacy of ulinastatin in intensive care unit (ICU) patients with sepsis and/or shock.All admitted to ICU Wuhu No. 2 People's Hospital between 2014 2017 were screened for potential eligibility this retrospective study. primary outcome was 28-day mortality, its correlation assessed using...

Previous studies have already revealed that triggering receptor expressed on myeloid cells-2 (TREM2) plays a significant protective role during the pathogenesis of ischemia injury in both brain and liver. This study aims to investigate effect TREM2 myocardial ischemic injury.The mice infarction (MI) model was established via left anterior descending coronary artery ligation. expression examined with RT-PCR Western blot. Whereafter, were randomly divided into control, sham, MI, Ad.TREM2...