A5106498871- Genomics and Phylogenetic Studies
- Oral microbiology and periodontitis research
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Microbial Community Ecology and Physiology
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced ceramic materials synthesis
- Nanocluster Synthesis and Applications
- Breast Lesions and Carcinomas
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- Plant biochemistry and biosynthesis
- Monoclonal and Polyclonal Antibodies Research
First Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Huashan Hospital
2023-2025
Bioprocessing Technology Institute
2024-2025
Agency for Science, Technology and Research
2024-2025
Northwest University
2025
Sun Yat-sen University
2019-2024
Shenyang Pharmaceutical University
2022-2024
Tianjin Medical University Cancer Institute and Hospital
2024
Fudan University
2023-2024
Capital Medical University
2024
While the importance of cell type specificity in plant adaptive responses is widely accepted, only a limited number studies have addressed this issue at functional level. We combined electrophysiological, imaging, and biochemical techniques to reveal physiological mechanisms conferring higher sensitivity apical root cells salinity barley (Hordeum vulgare). show that application apex arrests growth highly tissue- treatment-specific manner. Although salinity-induced transient net Na+ uptake...
BackgroundCardiovascular disease (CVD) remains a paramount contemporary health challenge. This study examined age-specific effects of 14 risk factors on CVD and mortality in different age groups.MethodsWe analyzed data from 226,759 CVD-free participants aged 40 years older the UK Biobank during period baseline time (2006–2010) to September 30, 2021. The primary outcome was composite incident coronary artery disease, heart failure, stroke. We calculated hazard ratios (HRs)...
The atherosclerotic vulnerable plaque is characterized by the foamy macrophage burden, involving impaired cholesterol efflux and deficient efferocytosis. Correspondingly, piezocatalytic therapy an emerging solution for eliminating burden with satisfactory spatiotemporal controllability deep penetration depth. Herein, a biomimetic Trojan horse (Au-ZnO@MM) engineered coating membrane (MM) onto surface of rod-like Au-ZnO Schottky Junction to effectively relieve progression. These horses MM are...
Semiconductor-based photoelectrochemical (PEC) biosensors have garnered significant attention in the field of disease diagnosis and treatment. However, recognition units these are mainly limited to bioactive macromolecules, which hinder photoelectric response due their insulating characteristics. In this study, we develop an situ-sensitized strategy that utilizes a small-molecule probe at interface photoelectrode accurately detect α-glucosidase (α-Glu) activity. Silane, prototype probe, was...
Abstract Background The Atribacterota are widely distributed in the subsurface biosphere. Recently, first isolate was described and number of genome sequences retrieved from environmental samples has increased significantly; however, their diversity, physiology, ecology, evolution remain poorly understood. Results We report isolation second member , Thermatribacter velox gen. nov., sp. within a new family Thermatribacteraceae fam. short-term laboratory cultivation JS1 lineage,...
<title>Abstract</title> <bold>Background:</bold> Functional near-infrared spectroscopy (fNIRS) is an advanced technique used to assess cortical activation and functional connectivity in the cerebral cortex brain. This study investigates changes patterns among patients with different subtypes of Parkinson’s syndrome during motor tasks. <bold>Methods</bold>: A total 63 participants, including 16 healthy controls, 23 disease (PD), 12 progressive supranuclear palsy (PSP), multiple system atrophy...
Occult breast cancer (OBC) is defined as axillary lymph node metastasis without any evidence of a primary tumor in the breast. Because limited number clinical cases, clinicopathological features and treatment recommendations OBC are still controversial. In addition, its natural history poorly understood proteomic signature remains unknown. We compared prognosis patients Non-OBC from Surveillance, Epidemiology, End Results (SEER) database analyzed effects local on survival outcomes patients....
Abstract Glycosylation alterations have emerged as significant indicators in the landscape of cancer diagnosis, with aberrant N-glycans standing out potential biomarkers. The existing methods for purifying mainly rely on their hydrophilicity, affinity, and size. These exhibit relatively weak binding forces low specificity based non-covalent interactions. Moreover, current liquid chromatography-based N-glycan purification detection techniques must be bettered clinical settings' rapid...
Biocatalysis using whole cell biotransformation presents an alternative approach to producing complex molecules when compared traditional synthetic chemical processes. This method offers several advantages, including scalability, self-contained co-factor recycling systems, the use of cost-effective raw materials, and reduced purification costs. Notably, microbial consortia provides benefits over monocultures by enhancing biosynthesis efficiency productivity through division labor a reduction...
Background Posterior reversible encephalopathy syndrome (PRES) is characterized by headaches, vision loss, confusion, encephalopathy, seizures, and focal edema on neuroimaging. Early recognition treatment of PRES are essential to prevent severe complications. Lenvatinib a multi-targeted kinase inhibitor that used as first-line for patients with hepatocellular carcinoma (HCC). Lenvatinib-induced less commonly recognized side effect. Case presentation A 72-year-old female patient HCC, who had...
A novel pale orange-coloured bacterium, designated strain SYSU D00532 T , was isolated from sandy soil collected the Gurbantunggut desert in Xinjiang, PR China. Cells of were found to be aerobic, Gram-stain-negative, oxidase-positive, catalase-positive, motile and rod-shaped with a single polar or subpolar flagellum. Growth occurred at 15–45 °C (optimum, 28–37 °C, pH 5.0–8.0 6.0–7.0) 0–1.5% NaCl (w/v; optimum, 0.5 %). The major lipids consisted diphosphatidylglycerol,...
Background: There is an interest in performing de-escalating axillary surgery after neoadjuvant chemotherapy (NAC). However, the significance of residual node disease NAC has not been well studied. Objectives: To investigate pathological lymph tumor burden (ypN) patients with initial clinical nodal stage cN0-1 breast cancer and determine its prognostic value. Design: Initial who received followed by at First Hospital Jilin University Affiliated Xi’an Jiaotong between January 2011 December...
Background The purpose of this study was to explore the association sleep patterns with development first cardiovascular diseases (FCVD), progression multimorbidity (CVM), and subsequently mortality. Methods Results This prospective included 381 179 participants without coronary heart disease, stroke, atrial fibrillation, or failure at baseline, they were followed up until March 31, 2021. We generated by summing scores for 5 behaviors, whereby <7 >8 hours/d sleep, evening chronotype,...
Abstract Peptide side chain stapling has been proven to be an effective strategy for fine‐tuning peptide properties. This innovative approach leads the creation of stapled peptides characterized by stabilized α‐helical conformations, enhanced protein‐binding affinity, improved cell permeability, superior enzymatic stability, and numerous other advantages. Extensive research explored impact various bridges on properties these peptides, with limited investigation into influence bridge...
Mcl-1 is a main antiapoptotic protein in acute myeloid leukemia (AML) and used as target to develop inhibitors. Currently, potent inhibitors primarily interact with the P2-P4 pockets of Mcl-1, but pharmacological modulation by targeting P1 pocket less explored. We designed series 1