M. Silva

ORCID: 0000-0002-3898-4645
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About
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Research Areas
  • HIV/AIDS drug development and treatment
  • Colorectal Cancer Screening and Detection
  • Reproductive Health and Technologies
  • Family Support in Illness
  • Complementary and Alternative Medicine Studies
  • Agricultural and Food Sciences
  • Economic and Financial Impacts of Cancer
  • Women's cancer prevention and management
  • Congenital Heart Disease Studies
  • RNA Research and Splicing
  • Acute Myeloid Leukemia Research
  • Olfactory and Sensory Function Studies
  • Family and Disability Support Research
  • HIV/AIDS Research and Interventions
  • Healthcare Regulation
  • Acupuncture Treatment Research Studies
  • Childhood Cancer Survivors' Quality of Life
  • Academic Research in Diverse Fields
  • Gastric Cancer Management and Outcomes

Universidade Federal do Rio Grande do Norte
2024

Hospital Santo António dos Capuchos
2022

Background: Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis characterized by a high rate of relapse after conventional combination chemotherapy, highlighting the need for improved therapeutic interventions. Genes involved in pre-mRNA splicing, namely SF3B1, U2AF1 and SRSF2, are frequently mutated AML.Recent studies suggest that pharmacological targeting splicing machinery results preferential lethality mutant AML cells, potentially providing novel...

10.1097/01.hs9.0000844440.63033.80 article EN cc-by-nc-nd HemaSphere 2022-06-01
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