A5000116708- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Electrolyte and hormonal disorders
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
Bury College
2022-2023
University College London
2022-2023
We hypothesized that the immunosuppressive effects associated with antibiotics, sedatives, and catecholamines amplify sepsis-associated immune suppression through mitochondrial dysfunction, there is a cumulative effect when used in combination. thus sought to determine impact of exemplar drugs ciprofloxacin, propofol, norepinephrine, alone combination, at clinically relevant concentrations, on ex vivo functionality peripheral blood mononuclear cells (PBMCs) drawn from healthy, infected,...
Mitochondrial dysfunction and immune cell are commonplace in sepsis associated with increased mortality risk. The short chain fatty acid, butyrate, is known to have anti-inflammatory effects promote mitochondrial biogenesis. We therefore explored the immunometabolic of butyrate an animal model sepsis. Isolated healthy human volunteer peripheral mononuclear cells were stimulated LPS presence absence released cytokines measured. Male Wistar rats housed metabolic cages received either...