A5052628069- Sepsis Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Takotsubo Cardiomyopathy and Associated Phenomena
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Ischemia and Reperfusion
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Intensive Care Unit Cognitive Disorders
- Adrenal Hormones and Disorders
- Respiratory Support and Mechanisms
- Probiotics and Fermented Foods
- Electrolyte and hormonal disorders
- Microbial Metabolites in Food Biotechnology
- Nitric Oxide and Endothelin Effects
- Clinical Nutrition and Gastroenterology
- Cancer-related cognitive impairment studies
- Gut microbiota and health
- Inflammasome and immune disorders
University Hospital Cologne
2021-2024
University of Cologne
2021-2024
University College London
2019-2023
Bury College
2021-2023
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels the neutrophil-derived enzyme myeloperoxidase (MPO) predict occurrence AICM in humans. We hypothesized MPO release causally contributes to AICM. Mice intravenously injected with doxorubicin (DOX) exhibited higher neutrophil counts and circulation cardiac tissue...
Introduction Myocardial infarction (MI) is a significant contributor to morbidity and mortality worldwide. Many individuals who survive the acute event continue experience heart failure (HF), with inflammatory healing processes post-MI playing pivotal role. Polymorphonuclear neutrophils (PMN) monocytes infiltrate infarcted area, where PMN release high amounts of heme enzyme myeloperoxidase (MPO). MPO has numerous properties plasma levels are correlated prognosis severity MI. While studies...
Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Improved survival has led to an increasing incidence ischemic cardiomyopathy, making it major reason for hospitalization in the western world. The inflammatory response myocardium determines extent structural remodeling functional deterioration, with neutrophils (PMN) being key modulator propagation resolution inflammation. heme enzyme myeloperoxidase (MPO) abundantly expressed PMN important mediator their...
Mitochondrial dysfunction and immune cell are commonplace in sepsis associated with increased mortality risk. The short chain fatty acid, butyrate, is known to have anti-inflammatory effects promote mitochondrial biogenesis. We therefore explored the immunometabolic of butyrate an animal model sepsis. Isolated healthy human volunteer peripheral mononuclear cells were stimulated LPS presence absence released cytokines measured. Male Wistar rats housed metabolic cages received either...
The six-transmembrane protein of prostate 2 (Stamp2) acts as an anti-inflammatory in macrophages by protecting from overt inflammatory signaling and Stamp2 deficiency accelerates atherosclerosis mice. Herein, we describe unexpected role polymorphonuclear neutrophils (PMN) characterize Stamp2’s protective effects myocardial ischemic injury. In a murine model ischemia reperfusion (I/R), echocardiography histological analyses revealed pronounced impairment cardiac function hearts...
Abstract Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels the neutrophil-derived enzyme myeloperoxidase (MPO) predict occurrence AICM in humans. We hypothesized MPO release causally contributes to AICM. Mice intravenously injected with Doxorubicin (DOX) exhibited higher neutrophil counts and circulation cardiac...