A5034555434- Advancements in Transdermal Drug Delivery
- Curcumin's Biomedical Applications
- Advanced Drug Delivery Systems
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Ocular Surface and Contact Lens
- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Trace Elements in Health
- Cholinesterase and Neurodegenerative Diseases
- Silymarin and Mushroom Poisoning
- Bee Products Chemical Analysis
- Lipid Membrane Structure and Behavior
- Pharmaceutical Practices and Patient Outcomes
- Heavy Metal Exposure and Toxicity
- Pesticide Exposure and Toxicity
- Paraquat toxicity studies and treatments
- Medicinal Plants and Neuroprotection
- Essential Oils and Antimicrobial Activity
- Biochemical effects in animals
- Saffron Plant Research Studies
- Pharmacological Effects of Medicinal Plants
- Synthesis and bioactivity of alkaloids
- Crystallization and Solubility Studies
- Heme Oxygenase-1 and Carbon Monoxide
Hamedan University of Medical Sciences
2017-2024
Yerevan State Medical University
2022
University of Auckland
2017
Tehran University of Medical Sciences
2013-2016
The main scope of the present investigation was to improve bioavailability perphenazine (PPZ) by incorporating it into nanostructured lipid carriers (NLCs).As a result lipophilic nature and poor aqueous solubility, as well extensive hepatic metabolism, PPZ has low systemic via oral route. NLCs have shown potentials surmount delivery drawbacks poorly water-soluble drugs.The PPZ-NLCs were prepared emulsification-solvent evaporation method subjected for particle size, zeta potential, entrapment...
Objective: The main goal of the present work was to develop and evaluate nanoemulsions (NEs) containing acyclovir (ACV) for ophthalmic drug delivery.Method: Firstly, component screening performed by determining ACV solubility in various oils, surfactants, co-surfactants. Different NE formulations were developed based on pseudo-ternary phase diagrams, physicochemical assets evaluated. Selected subjected release efficacy, stability studies, ex-vivo trans-corneal permeation test. safety NEs...
Abstract Glaucoma is an ocular disease i.e. more common in older adults with elevated intraocular pressure and a serious threat to vision if it not controlled. Due the limitations regarding conventional form of brinzolamide (Azopt®), two optimum formulations situ gel nanoemulsion were developed. To ensure safety efficacy developed for drug delivery, current study was designed. MTT assay carried out on human retinal pigmentation epithelial cells. investigate irritation potential chosen...
Fluconazole is an effective anti-fungal drug. Due to the limitations of fluconazole, such as poor water solubility and consequently low ocular bioavailability, optimized fluconazole nanoemulsion in-situ gel formulation (temperature-sensitive) was developed.To verify formulation's safety for ophthalmic use, preparation tested potential toxicity using a cell viability assay on retinal cells. The hen's egg test-chorioallantoic membrane (HET-CAM), borderline test between in vivo vitro...
Ocular fungal infections are one of the essential reasons for vision loss, especially in developing countries tropical regions. Ketoconazole (KZ), a broad-spectrum antifungal drug, is lipophilic compound and practically insoluble water. Since topical ophthalmic drug delivery confronts low bioavailability, an situ gel formulation designed to improve residence time consequently bioavailability. Safety developed as carrier was measured using three different methods: MTT assay measuring cell...
Paraquat (PQ) is a nonselective herbicide that induces oxidative reactions and multiple-organ failure on exposure. Crocin, carotenoid obtained from saffron, has demonstrated many therapeutic effects against neural conditions because of its antioxidant properties. In this study, 30 male Wistar rats were divided into 6 groups to evaluate the protective crocin crocin-loaded niosomes (NC) PQ in brain. The levels total capacity (TAC), lipid peroxidation (LPO), thiol (TTG), superoxide dismutase...
Resveratrol (RSV), as a natural polyphenol exhibiting antioxidative properties, is studied in the treatment of neurodegenerative diseases. However, RSV has low oral bioavailability. In this study and order to overcome issue, was encapsulated into solid lipid nanoparticles (SLNs). study, RSV‐loaded (RSV‐SLNs) were prepared by solvent emulsification‐evaporation technique, their physicochemical properties optimized using Box–Behnken response surface methodology. The morphology particles...
Propolis is a natural resinous product and exerts anti-inflammatory properties. The aim of this study formulation characterization solid lipid nanoparticles (SLNs) encapsulating propolis flavonoids (PFs), intended for topical treatment skin edema. were prepared statistically optimized using Box–Behnken response surface methodology. in vitro release profile the was investigated. Cytotoxicity on HSF-PI 18 cell line determined. Permeation penetration across incised measured. Finally,...
Tempol is a synthetic antioxidant. Since many studies revealed the protective effect of antioxidants on liver, current study was performed to assess hepatoprotective effects tempol streptozotocin induced diabetic rats. Blood glucose, oxidative toxic stress (OTS) biomarkers and liver enzymes were measured. Findings showed that significantly decreased serum levels glucose in treated group. Also treatment with reduced AST ALT compared control group (p < 0.05). Finally, OTS level It can be...