In this study, a thermosensitive in situ gel nanoemulsion was formulated by low energy method for intranasal delivery of temozolomide to bypass the blood-brain barrier and optimize chemotherapy glioblastoma. Various amounts Labrasol, Transcutol®P, Triacetin were chosen as components based on solubility partial pseudoternary phase diagrams studies. Poloxamer derivatives added selected gelling temperature optimized. The prepared containing showed mean droplet size <math...

The aim of this study was to investigate the corneal penetration brinzolamide (BZ) nanoemulsions (NEs) and evaluate their in vitro ex vivo irritancy potential. Twelve BZ NEs were prepared by spontaneous emulsification method permeability studies conducted using excised bovine corneas fixed onto Franz diffusion cells. To confirm safety formulations for ophthalmic use, preparations examined potential ocular a cell viability assay on retinal cells, Hen's Egg Test-Chorio-Allantoic Membrane...

The main scope of the present investigation was to improve bioavailability perphenazine (PPZ) by incorporating it into nanostructured lipid carriers (NLCs).As a result lipophilic nature and poor aqueous solubility, as well extensive hepatic metabolism, PPZ has low systemic via oral route. NLCs have shown potentials surmount delivery drawbacks poorly water-soluble drugs.The PPZ-NLCs were prepared emulsification-solvent evaporation method subjected for particle size, zeta potential, entrapment...

Objective: The main goal of the present work was to develop and evaluate nanoemulsions (NEs) containing acyclovir (ACV) for ophthalmic drug delivery.Method: Firstly, component screening performed by determining ACV solubility in various oils, surfactants, co-surfactants. Different NE formulations were developed based on pseudo-ternary phase diagrams, physicochemical assets evaluated. Selected subjected release efficacy, stability studies, ex-vivo trans-corneal permeation test. safety NEs...

Abstract Glaucoma is an ocular disease i.e. more common in older adults with elevated intraocular pressure and a serious threat to vision if it not controlled. Due the limitations regarding conventional form of brinzolamide (Azopt®), two optimum formulations situ gel nanoemulsion were developed. To ensure safety efficacy developed for drug delivery, current study was designed. MTT assay carried out on human retinal pigmentation epithelial cells. investigate irritation potential chosen...

Ocular fungal infections are one of the essential reasons for vision loss, especially in developing countries tropical regions. Ketoconazole (KZ), a broad-spectrum antifungal drug, is lipophilic compound and practically insoluble water. Since topical ophthalmic drug delivery confronts low bioavailability, an situ gel formulation designed to improve residence time consequently bioavailability. Safety developed as carrier was measured using three different methods: MTT assay measuring cell...

Cutaneous Leishmaniasis (CL) remains a significant public health concern, particularly in the tropical and subtropical regions. Present treatment options for CL such as Fluconazole (FLZ) face limitations, including low solubility bioavailability. This study aimed to address these challenges by investigating use of nano-emulsions (NEs) enhance efficacy FLZ against Leishmania major(L.major).

Abstract Background Perphenazine (PPZ) is a typical antipsychotic that mainly administrated for the treatment of schizophrenia. Due to its highly lipophilic nature and extensive hepatic first-pass metabolism, oral bioavailability low (40%). Objective The novel nanocarriers like solid lipid nanoparticles (SLN) have been reported be effective improving therapeutic effect drugs. Therefore main scope present investigation was evaluation in vivo characteristics PPZ-SLN terms pharmacokinetic...

Objective. Perphenazine (PPZ), as a typical antipsychotic medical substance, has the same effectiveness compared to atypical medications for treatment of schizophrenia. Despite lipophilic essence, PPZ encounters limited bioavailability caused by first-pass metabolism following oral administration. In present study, PPZ-containing solid lipid nanoparticles (PPZ-SLNs) were prepared and optimized based on different factors, including surfactant amount, develop appropriate safe novel dosage...

Low motility is one of the causes male infertility. In this study, effects progesterone solid lipid nanoparticles (SLNs) on sperm capacitation, acrosome reaction, oxidative stress and expression SPACA1 MAPK way genes were investigated. Progesterone SLNs synthesized using solvent emulsification evaporation method. Twenty asthenozoospermia samples selected, membrane integrity, motility, viability, total antioxidant capacity (TAC), status tests PKA, PTK, P38MAPK gene expressions assessed. The...

The present study aimed to develop and investigate besifloxacin (BSF) in situ gel nanoemulsions (NEs) consisting of two hydrophilic polymers, that is, poloxamer 407 (P407) 188 (P188), for ocular delivery. BSF loaded gel-NEs containing triacetin (oil), Cremophor ® RH 40 (surfactant), Transcutol P (co-surfactant), (gelling agents) were prepared by spontaneous emulsification method. optimum nanoemulsion was selected based on gelation temperature. formulation evaluated physicochemical...

The aim of this investigation was to design and develop nanoemulsions (NEs) as novel ophthalmic delivery systems for brinzolamide (BZD). Phase behavior quaternary composed triacetin CapryolTM 90 (selected oils, screened through the solubility studies), various surfactants (namely, Cremophor RH 40, Brij 35, Labrasol tyloxapol), Transcutol P (as co-surfactant) water at different surfactant/co-surfactant weight ratios (Rsm) investigated by construction phase diagrams. Formulations were taken...

Background Indomethacin as a non-steroidal anti-inflammatory drug (NSAID) is commonly used to treat some ocular inflammatory disorders. Unfortunately, indomethacin that poorly soluble in water; therefore, it has low efficacy. An attractive approach the targeted delivery of cornea using cationic dextran stearate polymeric micelle carrier. Methods A stearate-glycidyl trimethylammonium chloride (Dex-St-GTMAC) copolymer was prepared through reaction GTMAC, stearoyl chloride, and dextran. Then,...

The object of this study was to prepare binary and ternary solid dispersions atorvastatin (ATR) by the melting method using PEGs poloxamer 188 (P188) as carriers, singly in combination with each other. Dissolution behavior, solubility studies, X-ray diffractometry, differential scanning calorimetry, Fourier transform infrared spectroscopy were studied. Furthermore, antihyperlipidemic activities formulations compared other serum lipid analyses hyperlipidemic rats. Based on results, highest...

Brinzolamide (BZ) is a carbonic anhydrase inhibitor with selectivity and affinity for the type II isoenzyme that administrated topically as an ophthalmic suspension reducing intraocular pressure. In this study, BZ in situ gel nanoemulsions (NEs) were developed evaluated transcorneal permeation via bovine corneal membrane. The spontaneous emulsification method was employed to prepare NEs. Various physicochemical characteristics, including particle size, polydispersity index, pH, refractive...

Objective: The purpose of this study is to develop, optimize, and evaluate the in vivo effectiveness orally administered silibinin-loaded nanostructured lipid carriers (SB-NLCs) amyloid β-induced Alzheimer's disease Wistar rats.