Beneficial effects of genistein have been studied in various cancer types but the underlying molecular mechanisms its actions not well established. This study investigated on caspase-3 and p38 mitogen-activated protein kinase (p38MAPK) as main cellular signalling targets PC3 prostate cells.Caspase-3 p38MAPK gene expression intracellular levels were determined. Matrix metalloproteinase-2 (MMP2) gelatinase activity enzyme measured cell migration proliferation potencies assessed.Genistein...

There is a misconception that opium can lower blood sugar and cholesterol levels. Hence, this study aimed to investigate the influences of on expression key metabolism genes in liver intestine rats receiving cholesterol-rich diet. Male Wistar were randomly divided into four groups (n = 6): normal control, addiction, hypercholesterolemic diet, addiction received After 28 days, glucose levels, enzymes, rat's serum measured. The regulatory transporters such as 3-hydroxy-3-methylglutaryl...

ABSTRACT Background Methylenetetrahydrofolate reductase (MTHFR) has a key role in converting homocysteine to methionine so its deficiency might cause accumulation and arterial destruction. The aim of this study was evaluate the activity methylenetetrahydrofolate (MTHFR), homocysteine, MDA levels preeclampsia patients. Material Methods In case–control study, 30 patients healthy pregnant women as control group were selected matched for maternal age, gestational BMI. Preeclampsia confirmed by...

Low motility is one of the causes male infertility. In this study, effects progesterone solid lipid nanoparticles (SLNs) on sperm capacitation, acrosome reaction, oxidative stress and expression SPACA1 MAPK way genes were investigated. Progesterone SLNs synthesized using solvent emulsification evaporation method. Twenty asthenozoospermia samples selected, membrane integrity, motility, viability, total antioxidant capacity (TAC), status tests PKA, PTK, P38MAPK gene expressions assessed. The...

Oronasopharyngeal suction (ONPS) with a bulb at birth is traditional practice in the initial management of healthy infants Iran and many other countries. The purpose this study was to compare effects oronasopharyngeal those no normal, term newborns delivered vaginally. A total 170 first single uncomplicated pregnancies, clear amniotic fluid, vaginal delivery cephalic presentation, enrolled trial during labour. Newborns were randomised into one two groups, according use ONPS procedure....

Background Preeclampsia is a dangerous disease of pregnancy with symptoms such as high blood pressure and proteinuria. The nitric oxide synthase (NOS) enzyme produces (NO) mediator vasodilation need to calcium zinc ions for activity. thioredoxin reductase (TrxR) an containing selenium has been neutralized the damaging effects oxidants. In this study, our aim was evaluate activity eNOS TrxR enzymes amounts calcium, zinc, elements in serum women preeclampsia.Material Methods Thirty...

Background: Methylenetetrahydrofolate reductase enzyme (MTHFR) plays a key role in regulating folate balance, converting homocysteine to methionine, and producing s-adenosylmethionine (SAM) that the methylation process. Objective: This study aimed determine MTHFR activity SAM level men with normozoospermia oligozoospermia. Materials Methods: 30 oligozoospermic normozoospermic as controls were enrolled this case-control study. Semen analysis was conducted according world health organization...

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) protein is one of the factors associated with oxidative stress and dyslipidemia disorders. Objective: This study aimed to evaluate lipid profile, PCSK9 levels, in preeclampsia. Materials Methods: case-control was conducted at Sina hospital Hamadan University Medical Sciences, Hamadan, Iran from August 2020-May 2021. The average maternal age included participants 30 yr preeclampsia healthy pregnant women. After clinical...

Neopterin is a significant and sensitive marker in estimating the activity of cellular immune system. Oxidative stress plays role etiology male infertility. Increased reactive oxygen species accompanied with increase neopterin level. Hence may be involved infertility.The objective this case-control study was to determine level idiopathic infertile normospermic men; furthermore, identify its relationship oxidative markers including total oxidant, malondialdehyde, sperm DNA fragmentation,...

Major depressive disorder (MDD) is one of the common psychiatric disorders that characterized by abnormal neurobiological responses. Proprotein convertase subtilisin/kexin 9 (PCSK9) important in cholesterol homeostasis.

Abstract Cu nanoparticles (CuNPs) have various applications in biomedicine, owing to their unique properties. As the effect of CuNPs on induction oxidative stress and apoptosis human colorectal cancer cell line SW480 has not yet been studied, we investigated toxicity mechanism action these NPs cells. An MTT assay was performed assess particles viability The levels were assessed after 24h treatment with by evaluating ROS production. Antioxidant enzyme activity using a colorimetric method. To...

Background: Genistein is an isoflavone that has been reported to have various anti-cancer properties. Objectives: This study aimed reveal whether or not the properties of genistein in AGS gastric cancer cell line were mediated through caspase-3 enzyme. Methods: cells treated with different concentrations for 12, 24, and 48 hours and, then, viability IC50 determined. To determine effect on migration potency, wound healing assay was performed. The genistein-induced apoptosis evaluated by flow...

Background & Objective: PCOS is a multifactorial disorder characterized by inflammation caused unknown reasons. This study aimed to investigate the Arachidonic acid (AA), eicosapentaenoic (EPA) levels and Serum amyloid A (SAA) protein gene expression of follicular fluid in women with PCOS.Materials Methods: The included 30 healthy women. individuals were selected after clinical examination inclusion criteria. During puncture removing oocytes, fluids collected from individuals. SAA...

Background: Tamoxifen is an effective drug for breast cancer treatment and its side effects are the production of reactive oxygen species kidney damage. As antioxidants, vitamins E D may help decrease dysfunction. Objectives: In present study, protective on renal toxicity caused by tamoxifen in female Wistar rats were investigated. Materials Methods: Twenty-five adult weighing 180-200 randomly divided into five groups with 5 rats. Group C, T, TE, TD, TED treated olive oil, tamoxifen, +...

Background & Objective: Trace element levels are important for sperm function.On the other hand, oxidative stress is one of most causes DNA damage.This study aimed to evaluate relationship between cadmium (Cd), nickel (Ni), and manganese (Mn) trace elements also in infertile men. Materials Methods:This case-control was carried out on 50 oligozoospermic, asthenozoospermic, normozoospermic men.All individuals were subjected semen analysis.Cadmium, nickel, manganese, total antioxidant capacity...