Abstract Objectives Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated (MAFLD), can also manifest in patients classified non-MAFLD who do not meet MAFLD criteria. The involvement of cortisol and thyroid hormones may play a role the pathogenesis FLD by modifying metabolism specific lipoproteins, particularly apolipoprotein M ( Apo ). This study investigated levels gene expression white blood cells (WBCs) individuals with MAFLD, non-MAFLD,...

Background: Epidemiological studies on liver transplant (LT) patients can provide valuable information about the etiology and trends of cirrhosis. The present study aimed to investigate prevalence trend different etiologies survival rates LT at Namazi Transplant Center in Shiraz, Iran, between 2001 2018. Methods: In this single-center, retrospective cohort study, demographic clinical characteristics 3751 who underwent met inclusion criteria, including age, gender, blood group, body mass...

Abstract The conversion of simple steatosis into nonalcoholic steatohepatitis (NASH) in patients with fatty liver disease (NAFLD) has attracted many attentions recent years. role the hedgehog (HH) pathway regulation lipogenesis been addressed literature. This study aimed to investigate levels sonic (SHH) and Indian (IHH) ligands correlation these proteins involved transforming growth factor‐β1 (TGF‐β1) pathway, as well evaluation transcriptional coactivator PDZ binding motif (TAZ) expression...

Abstract Numerous investigations have been performed on the role of transforming growth factor‐β1 (TGF‐β1) pathway in development chronic liver diseases (CLDs); however, they failed to explain underlying mechanism its pathogenesis, suggesting that other alternative pathways might overlooked. The involvement yes‐associated protein1 (YAP1) has attributed fibrosis; yet, precise function this protein not fully understood. Therefore, study aimed investigate activity YAP1 human cirrhosis...

Abstract The pivotal role of the extracellular matrix (ECM) as both a cause and consequence liver fibrosis is striking. However, mechanotransducer molecules profibrogenic factors induced by stiffness are still unclear. current study aimed to investigate its correlation with expression transcriptional coactivator PDZ‐binding motif (TAZ) serum osteopontin (OPN) in human cirrhosis. In this case−control study, tissue was determined using atomic force microscopy cirrhotic livers ( n = 38)...

Matrix metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim this study is to determine prevalence C-1562T MMP-9 (rs3918242) gene polymorphism fertile infertile men. In addition, we association between G-1575A MMP-2 polymorphisms.A total 400 subjects, including 200 men, were recruited for casecontrol study. allele frequencies genotype distributions single nucleotide promoter regions (C-1562T) determined using polymerase...

Background and aim: Cirrhosis is a major public health problem worldwide. The prevalence of cirrhosis various in different geographical regions. aim the present study was to determine distribution etiologies their proportional changes through recent 11 years Iran. Methods: In this retrospective, observational study, data cirrhotic patients who have been listed for liver transplantation Namazi Transplant Center (Shiraz, Iran) between January 2006 December 2016 were analyzed. Demographic...

Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in tissue that is usually associated with metabolic disorders. Traditionally, regarded as a spectrum pathological conditions ranging from simple steatosis (SS) non-alcoholic steatohepatitis (NASH) and hepatic fibrosis progression cirrhosis. However, so far, there no available explanation for progression. Several signaling pathways such transforming growth factor (TGF)-β, hedgehog (HH), yes-associated protein 1...

Background: The evaluation of different cell proliferation and apoptosis indicators in cirrhotic tissues caused by injuries may help recognize the etiology cirrhosis risk progression to hepatocellular carcinoma. Objectives: This study aimed measure p53 gene expression AMPK pAMPK protein expressions, as well AgNOR features associated with five etiologies comparison simple hepatic steatosis controls. Methods: In this case-control study, PAMPK expression, were investigated 68 liver obtained...

The impaired functions of granulosa cells (GCs) in the delayed development and immaturity oocytes have been reported polycystic ovary syndrome (PCOs). Even with ovarian stimulation, a large number these patients are still stage germinal vesicle (GV).

Cirrhosis is often an asymptomatic disease. Its early diagnosis before the development of life-threatening complications important step to prevent progression The aim present study was identification parameters that are significantly changed in cirrhosis, not affected by cause and associated with fatal cirrhosis.Demographic pre-transplant ultrasound laboratory findings were reviewed patients viral- (n = 27), autoimmune hepatitis- alcohol- 18), primary sclerosing cholangitis- (PSC) 36),...

[Figure: see text] It is assumed that high lipid profile (HLP) causes chronic systemic inflammation, which ultimately leads to inflammatory diseases and cancers. The aim of the study was investigate serum concentration proinflammatory/tumor markers interleukin-17 (IL-17), carcinoembryonic antigen (CEA), prostate-specific (PSA) in HLP. HLP cases [F/M: 11/17 triglyceride (TG) >200 mg/dL, high-density lipoprotein (HDL) <50 mg/dL for females HDL <40 males] controls (F/M: 12/15, TG <200 mg/dL)...

Background: Tamoxifen is an effective drug for breast cancer treatment and its side effects are the production of reactive oxygen species kidney damage. As antioxidants, vitamins E D may help decrease dysfunction. Objectives: In present study, protective on renal toxicity caused by tamoxifen in female Wistar rats were investigated. Materials Methods: Twenty-five adult weighing 180-200 randomly divided into five groups with 5 rats. Group C, T, TE, TD, TED treated olive oil, tamoxifen, +...

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases, from steatosis to cirrhosis. Simple remains stable over time, and its development into non-alcoholic steatohepatitis (NASH) takes several years. Several pathways are involved in the progression NAFLD, including transforming growth factor-β (TGF-β), Hedgehog (Hh), Hippo, AMP-activated protein kinase (AMPK) signaling pathways. These have complex interplay, each pathway can either activate or inhibit other This review...

Abstract Background. The effect of cirrhosis etiology on the development HCC is unclear. study main indicators cell proliferation and also apoptosis in cirrhotic patients with different etiologies may declare which one more predispose to HCC. present aimed investigate gene expression p53, hepatic levels AMPK pAMPK, AgNOR features livers simple steatosis. Methods. pAMPK protein levels, p53 expression, were studied NASH(n=8), HBV/HCV(n=8), AIH(n=8), PSC(n=8), alcohol(n=6) cirrhosis, 10...

Abstract Background . The effect of cirrhosis etiology on the development HCC is unclear. study main indicators cell proliferation and also apoptosis in cirrhotic tissues with different etiologies may declare which one more predispose to HCC. present aimed investigate gene expression p53, AMPK pAMPK protein expressions AgNOR features livers etiologies, simple steatosis, controls. Methods. levels, p53 expression, were studied NASH(n=15), HBV/HCV(n=14), AIH(n=15), PSC(n=15), alcohol(n=9)...

Background: Integrins are transmembrane mechanosensitive proteins that negatively contribute to the pathogenesis of different types chronic liver disease and can activate focal adhesion kinase (FAK). Objectives: This study aimed determine hepatic integrin β1 FAK mRNA as well transcriptional coactivator with PDZ-binding motif (TAZ) protein expressions in cirrhotic patients simple steatosis. Methods: In this case–control study, tissues were collected from 30 various etiologies (i.e.,...