A5080702730- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis of Organic Compounds
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Metal complexes synthesis and properties
- Synthesis of Tetrazole Derivatives
- Computational Drug Discovery Methods
- Synthesis of Indole Derivatives
- Cancer therapeutics and mechanisms
- Wastewater Treatment and Nitrogen Removal
- Inorganic and Organometallic Chemistry
- Natural product bioactivities and synthesis
- Anaerobic Digestion and Biogas Production
- Phytochemistry and Biological Activities
- Free Radicals and Antioxidants
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Constructed Wetlands for Wastewater Treatment
- Synthesis and Reactions of Organic Compounds
National Research Centre
2015-2024
National Water Research Center
2012-2022
Menoufia University
2018
Université Clermont Auvergne
2010
Cairo University
2010
Physique et Physiologie Intégratives de l'Arbre en Environnement Fluctuant
2010
Ajayi Crowther University
2009
Wageningen University & Research
2000-2006
In this study, hybrid carbon dots–plasmonic nanostructures including dots/polyethyleneimine/gold (C-dots/PEI/Au), and dots/polyethyleneimine/silver (C-dots/PEI/Ag) have been prepared using a MWI method for biomedical imaging.
The molecular hybridization concept has recently emerged as a powerful approach in drug discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed and developed via protocol antitumor agents. target compounds (5a–j 7a–e) prepared by reaction 5-aminopyrazoles (1a–e) with N-substituted isatin (4a,b) 1H-indole-3-carbaldehyde (6), respectively. All products characterized several analytical spectroscopic techniques. Compounds screened for their cytotoxicity...
In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of synthesised 2, 5, 7, 13–18 was studied against HCT-116 MCF-7 cell lines MTT assay. triazole glycosides 16 18 provided significant activities comparable to that doxorubicin other compounds. behaviour exhibited all investigated compounds were more potent than doxorubicin. Moreover,...
Abstract New system compromising of chitosan nanoparticles encapsulated pre-synthesized selenium in the presence 5-fluorouracil was successfully prepared and used for cancer antiproliferation. Selenium were synthesized using ascorbic acid as reducing agent under mild condition. Chitosan via ionic gelation technique sodium tri-polyphosphate. Characterization carried out FTIR, TEM, XRD, TGA dynamic light scattering (DLS). The results displayed formation with an average size 20 nm 207 250 neat...
A structure−activity study on the quinone/quinone methide chemistry of a series 3',4'-dihydroxyflavonoids was performed. Using glutathione trapping method followed by HPLC, 1H NMR, MALDI-TOF, and LC/MS analysis to identify glutathionyl adducts, chemical behavior quinones/quinone methides different flavonoids could be deduced. The nature type mono- diglutathionyl adducts formed from quercetin, taxifolin, luteolin, fisetin, 3,3',4'-trihydroxyflavone show how several structural elements...
Xylem vulnerability to cavitation is a key parameter in understanding drought resistance of trees. We determined the xylem water pressure causing 50% loss hydraulic conductivity (P50), proxy cavitation, and we evaluated variability this trait at tree population levels for Fagus sylvatica. checked effects light on stem segments together with time series variation P50. Full sunlight-exposed were less vulnerable than shade-exposed ones. found no clear seasonal change P50, suggesting that was...
New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolyl)thiaazaspiro[4.5]decane thiazolopyrimidinethione by glycosylation reactions using acetylated glycosyl bromides. anticancer activity was studied against cell culture HepG-2 (human liver hepatocellular carcinoma), PC-3 prostate adenocarcinoma) HCT116 colorectal carcinoma) lines a number showed...
New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different aldose sugars. Heterocyclization formed afforded derived acyclic nucleoside analogues possessing 1,3,4-oxadiazoline as modified nucleobase via acetylation followed heterocyclization process. The anticancer activity compounds was studied against human liver carcinoma cell (HepG-2) and at normal retina pigmented epithelium cells (RPE-1). High...
Formation of quercetin quinone/quinone methide metabolites, reflected by formation the glutathionyl adducts as authentic was investigated in an vitro cell model (B16F-10 melanoma cells). Results present study clearly indicate a tyrosinase-containing line, expected to be representative also for peroxidase-containing mammalian cells and tissues. The data obtained support that are formed intracellular subsequently excreted into incubation medium reveal first time evidence pro-oxidative...
A novel series of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazolo[1,5-a]quinazolines 18a, b were synthesized via condensation 5-amino-1H-pyrazoles 10a, with 3-(dimethylamino)-1-aryl-prop-2-en-1-ones 11a–e 2-((dimethylamino)methylene)-5,5-dimethylcyclohexane-1,3-dione (15), respectively, in glacial acetic acid. Finally, treatment sodium nitrite (NaNO2) afforded pyrazolo[3,4-d]triazines 20a, b. Structures compounds confirmed by their spectral data. These screened for vitro cytotoxic activities...
A series of N-aryl-7-aryl-pyrazolo[1,5-a]pyrimidines 18a⁻u and N-aryl-pyrazolo[1,5-a]quinazolines 25a⁻c were designed synthesized via the reaction 5-aminopyrazoles 11a⁻c with enaminones 12a⁻g or 19, respectively. The new compounds screened for their in vitro antitumor activity toward liver (HepG-2) breast (MCF-7) human cancer cells using 3-[4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide MTT assay. From results, it was found that all showed dose-dependent cytotoxic activities...
New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared thiol compounds. Click strategy was also used for synthesis new and 1,2,3-triazole hybrid glycosides by reaction acetylenic derivatives with different glycosyl azids followed deacetylation process. The cytotoxic activities compounds studied against HCT-116 (human colorectal carcinoma) MCF-7 breast adenocarcinoma) cell lines using MTT assay. results showed that key...