A5043386016- Child Nutrition and Water Access
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Child Nutrition and Feeding Issues
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Non-Destructive Testing Techniques
- Geophysical Methods and Applications
- Geophysical and Geoelectrical Methods
- Infant Nutrition and Health
- Endoplasmic Reticulum Stress and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
University Medical Center Groningen
2017-2023
University of Groningen
2017-2023
Hospital for Sick Children
2016-2023
Diarrhea affects a large proportion of children with severe acute malnutrition (SAM). However, its etiology and clinical consequences remain unclear.We investigated diarrhea, enteropathogens, systemic intestinal inflammation for their interrelation associations mortality in SAM.Intestinal pathogens (n = 15), cytokines 29), fecal calprotectin, the short-chain fatty acids (SCFAs) butyrate propionate were determined aged 6-59 mo 79) hospitalized Malawi complicated SAM. The relation between...
The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes such as SIRT1- mTORC1-mediated autophagy mitochondrial homeostasis. Using a mouse organoid model SM, we studied repercussions these dysregulations on enteropathy protective capacity maintaining activity health.SM was induced through feeding male weanling C57BL/6 mice low...
Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels suggest a possible disturbance the tryptophan-nicotinamide adenine dinucleotide (TRP-NAD+) pathway and subsequently NAD+ dependent metabolism regulator sirtuin1 (SIRT1). Here we show that weanling mice, induced by 2-weeks low protein diet feeding from weaning, leads an impaired TRP-NAD+ decreased affects hepatic mitochondrial turnover...
Objective Severe acute malnutrition (SAM) is a major cause of mortality in children under 5 years and associated with hepatic steatosis. Bile acids are synthesized the liver participate dietary fat digestion, regulation energy expenditure, immune responses. The aim this work was to investigate whether SAM clinically relevant changes bile acid homeostasis. Design An initial discovery cohort healthy controls 22 SAM-patients used identify altered A follow up 40 were then studied on admission 3...
Background Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality delayed recovery. We tested the hypothesis that a lactose-free, low-carbohydrate F75 milk would serve limit these risks, thereby reducing number days in stabilization phase. Methods findings In multicenter double-blind trial, hospitalized severely malnourished children were...
Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates clearance lipid oxidation also enhances sensitivity (IS). It is not well known how exercise interacts with age diet resistance. To investigate this, oral tolerance tests tracers were conducted mice ranging from 4 to 21 months age, fed a low-fat (LFD) or high-fat (HFD) without...
The case fatality rate of severely malnourished children during inpatient treatment is high and mortality often associated with diarrhea. As intestinal carbohydrate absorption impaired in severe acute malnutrition (SAM), differences dietary formulations nutritional rehabilitation could lead to the development osmotic diarrhea subsequently hypovolemia death. We compared three strategies commonly used transition higher caloric feeds, i.e., F100 milk (F100), Ready-to-Use Therapeutic Food (RUTF)...
Hospitalized children with severe malnutrition face high mortality rates and often suffer from hepatic intestinal dysfunction, negative impacts on their survival. New treatments cannot be developed without understanding the underlying pathophysiology. We have established characterized translational organoid models of liver intestine. In these models, amino acid starvation recapitulates expected organ-specific functional changes (e.g., steatosis, barrier dysfunction) accompanied by reduced...
Abstract Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates clearance, lipid oxidation enhances sensitivity. It is not well known how exercise interacts with age diet resistance. To investigate this, oral tolerance tests (OGTT) a tracer were conducted mice ranging from 4 to 21 months age, fed low- (LFD) or high-fat (HFD), without...
Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates clearance, lipid oxidation enhances sensitivity. It is not well known how exercise interacts with age diet resistance. To investigate this, oral tolerance tests (OGTT) a tracer were conducted mice ranging from 4 to 21 months age, fed low- (LFD) or high-fat (HFD), without life-long...
Abstract Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels suggest a possible disturbance the tryptophan-nicotinamide (TRP-NAM) pathway and subsequently NAD+ dependent metabolism regulator sirtuin1 (SIRT1). We report that weanling mice, induced by feeding low protein diet, leads an impaired TRP-NAM affects hepatic mitochondrial turnover function. demonstrate stimulating improves...
<p> Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates clearance, lipid oxidation enhances sensitivity. It is not well known how exercise interacts with age diet resistance. To investigate this, oral tolerance tests (OGTT) a tracer were conducted mice ranging from 4 to 21 months age, fed low‑ (LFD) or high-fat (HFD), without...
<p> Diet modulates the development of insulin resistance during aging. This includes tissue-specific alterations in signaling and mitochondrial function, which ultimately affect glucose homeostasis. Exercise stimulates clearance, lipid oxidation enhances sensitivity. It is not well known how exercise interacts with age diet resistance. To investigate this, oral tolerance tests (OGTT) a tracer were conducted mice ranging from 4 to 21 months age, fed low‑ (LFD) or high-fat (HFD), without...
Background: Despite a reduction of child mortality in low-income countries, acutely ill undernourished children still have an elevated risk death. Those at highest are with severe acute malnutrition (SAM) who often show metabolic dysregulation that remains poorly understood. Objective: We performed pilot study to examine changes urinary organic acids during nutritional rehabilitation SAM, and identify metabolites associated the presence edema or mortality. Methods: This included 76 aged...