A5081194085- Venous Thromboembolism Diagnosis and Management
- Peptidase Inhibition and Analysis
- Synthetic Organic Chemistry Methods
- Protease and Inhibitor Mechanisms
- Mitochondrial Function and Pathology
- Lanthanide and Transition Metal Complexes
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Renal cell carcinoma treatment
- Genetic Neurodegenerative Diseases
- Dendrimers and Hyperbranched Polymers
- Fungal and yeast genetics research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac tumors and thrombi
- Angiogenesis and VEGF in Cancer
Northwestern University
2022-2024
International Institute for Nanotechnology
2024
McCormick (United States)
2024
National Institutes of Health Clinical Center
2022-2023
Successful and selective inhibition of the cytosolic protein-protein interaction (PPI) between nuclear factor erythroid 2-related 2 (Nrf2) Kelch-like ECH-associating protein 1 (Keap1) can enhance antioxidant response, with potential for a therapeutic effect in range settings including neurodegenerative disease (ND). Small molecule inhibitors have been developed, yet many off-target effects, or are otherwise limited by poor cellular permeability. Peptide-based strategies also attempted to...
Nanoparticles that undergo a localized morphology change to target areas of inflammation have been previously developed but are limited by their lack biodegradability. In this paper, we describe low-ring-strain cyclic olefin monomer, 1,3-dimethyl-2-phenoxy-1,3,4,7-tetrahydro-1,3,2-diazaphosphepine 2-oxide (MePTDO), rapidly polymerizes via ring-opening metathesis polymerization at room temperature generate well-defined degradable polyphosphoramidates with high monomer conversion (>84%)....
Abstract Hepatocellular carcinoma (HCC) is an aggressive liver cancer with limited effective treatment options. In this study, we selected TLR agonists imiquimod (IMQ), gardiquimod (GARD), GS-9620 and DSR 6434, a small molecule checkpoint inhibitor, BMS-202, for characterization of drug loading release from radiopaque embolic beads (DC Bead LUMI) potential use in image-guided transarterial embolization (TACE) HCC. The maximum capacity amount released over time were determined by high...
Recently, it has been shown that blocking the binding of valosin-containing protein (VCP) to mutant huntingtin (mtHtt) can prevent neuronal mitochondrial autophagy in Huntington's disease (HD) models. Herein, we describe development and efficacy a protein-like polymer (PLP) for inhibiting this interaction cellular vivo models HD. PLPs exhibit bioactivity HD mouse striatal cells by successfully destruction. PLP is notably resilient vitro enzyme, serum, liver microsome stability assays, which...
ABSTRACT Nanoparticles that undergo a localized morphology change to target areas of inflammation have been previously developed but are limited by their lack biodegradability. In this paper, we describe low ring strain cyclic olefin monomer, 1,3-dimethyl-2-phenoxy-1,3,4,7-tetrahydro-1,3,2-diazaphosphepine 2-oxide (MePTDO), rapidly polymerizes via ring-opening metathesis polymerization (ROMP) at room temperature generate well-defined degradable polyphosphoramidates with high monomer...