A5084940825- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Membrane Separation Technologies
- Synthesis and properties of polymers
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
- Neuroendocrine regulation and behavior
- Antimicrobial Peptides and Activities
- Dendrimers and Hyperbranched Polymers
- Genetic Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Microfluidic and Capillary Electrophoresis Applications
- biodegradable polymer synthesis and properties
- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
Boston Children's Hospital
2024
Harvard University
2024
Northwestern University
2019-2024
International Institute for Nanotechnology
2019-2021
Seoul National University
2013-2015
Herein, we report the photoinitiated polymerization-induced self-assembly (photo-PISA) of spherical micelles consisting proapoptotic peptide-polymer amphiphiles. The one-pot synthetic approach yielded micellar nanoparticles at high concentrations and scale (150 mg mL-1 ) with tunable peptide loadings up to 48 wt. %. size was tuned by varying lengths hydrophobic hydrophilic building blocks. Critically, peptide-functionalized imbued "KLA" peptides (amino acid sequence: KLAKLAKKLAKLAK) two key...
Abstract Harnessing metal‐free photoinduced reversible‐deactivation radical polymerization (photo‐RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme‐responsive pro‐apoptotic peptide brush polymers. Thermolysin‐responsive peptide‐based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo morphology transition worm‐like micelles upon enzyme‐triggered cleavage of coronal sidechains. Moreover, polypeptide brushes show enhanced cell uptake...
Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in developed world. Current therapy includes monthly intraocular injections anti-VEGF antibodies, which are ineffective up to one third patients. Thrombospondin-1 (TSP1) inhibits angiogenesis via CD36 binding, and its down-regulated expression negatively associated with onset nAMD. Here, we describe TSP1 mimetic protein-like polymers (TSP1 PLPs). PLPs bind high affinity, resist degradation, show prolonged...
A simple strategy for generating stimuli-responsive peptide-based hydrogels
Peptide-brush polymers (PBPs), wherein every side-chain of the is peptidic, represent a new class proteomimetic with unusually high proteolytic resistance while maintaining bioactivity. Here, we sought to determine origin this behavior and assess its generality via combined theory experimental approach. A series PBPs various polymer backbone structures were prepared examined for their stability We discovered that an increase in hydrophobicity backbones predictive elevation peptides. Computer...
Abstract Herein, we report the photoinitiated polymerization‐induced self‐assembly (photo‐PISA) of spherical micelles consisting proapoptotic peptide–polymer amphiphiles. The one‐pot synthetic approach yielded micellar nanoparticles at high concentrations and scale (150 mg mL −1 ) with tunable peptide loadings up to 48 wt. %. size was tuned by varying lengths hydrophobic hydrophilic building blocks. Critically, peptide‐functionalized imbued “KLA” peptides (amino acid sequence:...
Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver disease first reported over century ago, but its management still poses an unmet challenge. A therapeutic agent found to stabilize the condition short cyclic peptide, vasopressin analogue, terlipressin (TP). While TP commonly prescribed for HRS patients in most parts world, it was only recently approved use United States. exhibits circulation half-lives and adverse side effects associated with dose required....
Abstract Harnessing metal‐free photoinduced reversible‐deactivation radical polymerization (photo‐RDRP) in organic and aqueous phases, we report a synthetic approach to enzyme‐responsive pro‐apoptotic peptide brush polymers. Thermolysin‐responsive peptide‐based polymeric amphiphiles assembled into spherical micellar nanoparticles that undergo morphology transition worm‐like micelles upon enzyme‐triggered cleavage of coronal sidechains. Moreover, polypeptide brushes show enhanced cell uptake...
Polymeric nanoscale materials able to target and accumulate in the tumor microenvironment (TME) offer promising routes for a safer delivery of anticancer drugs. By reaching their targets before significant amounts drug are released, such can reduce off-target side effects maximize concentration TME. However, poor loading capacity inefficient nanomaterial penetration into limit therapeutic efficacy. Herein, we provide novel approach achieve high profiles while ensuring fast efficient tumor....
Abstract Fumaramic acid derivatives can be converted into their cis isomer maleamic under UV illumination, and these show pH‐responsive degradability at acidic pH only after the preceding photoisomerization. The rate of tandem photoisomerization–degradation fumaramic finely controlled by changing substituents on double bond. Photoisomerization‐based unlocking has strong potential for development multisignal‐responsive smart materials in biomedical applications.
Recently, it has been shown that blocking the binding of valosin-containing protein (VCP) to mutant huntingtin (mtHtt) can prevent neuronal mitochondrial autophagy in Huntington's disease (HD) models. Herein, we describe development and efficacy a protein-like polymer (PLP) for inhibiting this interaction cellular vivo models HD. PLPs exhibit bioactivity HD mouse striatal cells by successfully destruction. PLP is notably resilient vitro enzyme, serum, liver microsome stability assays, which...
Abstract In this Minireview, we describe synthetic polymers densely functionalized with sequence‐defined biomolecular sidechains. We focus on brush of oligonucleotides, oligosaccharides, and oligopeptides, prepared via graft‐through polymerization from biomolecule monomers. The resulting structures are wherein a graft is positioned at each monomer backbone unit. key milestones, identify opportunities, highlight recent advances in the field, including biological applications.
Peptid-Bürstenpolymere wurden durch photoinduzierte radikalische Polymerisation unter reversibler Deaktivierung (photo-RDRP) hergestellt, wie N. C. Gianneschi et al. in ihrem Forschungsartikel auf S. 17520 berichten. Die Autoren schlagen sie als neue Klasse von “Polypeptiden” vor, bei denen die Peptide entlang eines synthetischen Polymerrückgrats organisiert sind. Diese definierten, multivalenten Strukturen haben abstimmbare biologische Aktivitäten und damit ein enormes Potenzial für Biomedizin.