Abstract In general, chest radiographs (CXR) have high sensitivity and moderate specificity for active pulmonary tuberculosis (PTB) screening when interpreted by human readers. However, they are challenging to scale due hardware costs the dearth of professionals available interpret CXR in low-resource, PTB burden settings. Recently, several computer-aided detection (CAD) programs been developed facilitate automated interpretation. We conducted a retrospective case-control study assess...

In the rapidly evolving landscape of 21st century, technology has become an integral part our daily lives, reshaping industries and revolutionizing way businesses operate. The business hotel industry, in particular, have witnessed significant transformations as a result recent technological trends. This Paper explores impact these trends on both sectors, examining how advancements shaped their strategies, operations, customer experiences.

Background: Microorganisms are known to be involved in the formation of biofilm. These biofilms often seen chronic wound infections, surgical site implants etc., capable causing recalcitrant infections and most them also possess high antibiotic resistance. Objectives: This study was conducted detect biofilm bacterial isolates from infections. Materials Methods: In present study, ninety two were identified by MALDI-TOF-MS (bioMerieux) VITEK-2-MS (bioMerieux). further screened for three...

Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the process of arabinogalactan and lipoarabinomannan biosynthesis, has become target choice for anti-TB drug discovery recent past. The current study aims to find potential DprE1 inhibitors through in-silico approaches. Here, we built pharmacophore 3D-QSAR model using reported 40 azaindole derivatives inhibitors. best hypothesis (ADRRR_1) was employed virtual screening chEMBL database. To identify prospective...

Nonfermenting gram-negative bacilli have emerged as important healthcare-associated pathogens. It is to correctly identify all clinically significant nonfermenting considering the intrinsic multidrug resistance exhibited by these bacteria.A retrospective study was undertaken various other than Pseudomonas aeruginosa and Acinetobacter spp. isolated from respiratory samples (n = 9363), understand their clinical relevance analyze antibiotic susceptibility pattern.Nonfermenting were 830 (16.4%)...

Background: The presence of granuloma, visualized in histopathology for diagnosing tuberculosis tissue samples, is not a specific finding. Moreover, histopathological examination sections needs one to two weeks final reporting. A rapid and sensitive method therefore needed detection Mycobacterium these paucibacillary samples. Methodology: PCR-assay IS6110 was evaluated 104 different samples comparison that considered gold standard. Results: PCR showed 74.1% sensitivity 96.1% specificity....

This study aimed to see if rifampicin susceptibility can be determined on repeat sampling in pulmonary tuberculosis with a trace call the first GeneXpert Ultra report. retrospective cohort included adults respiratory sample from January 2021 June 2024. Of 27 patients done after initial call, could 37% (n=10) of patients. Repeating testing an is valuable for determining susceptibility.

Anaerobic bacteria which constitute a significant proportion of the normal microbiota also cause variety infections involving various anatomic sites. Considering tedious culture techniques with longer turnaround time, anaerobic cultures are usually neglected by clinicians and microbiologists.To study frequency isolation different from clinical specimens.A retrospective to analyse bacteria, was conducted over period five years 2011 2015 including specimens submitted division Microbiology...

Stenotrophomonas maltophilia infection is gaining importance as an important cause of nosocomial pneumonia due to its characteristic inherent resistance many broad- spectrum antibiotics. In this study we evaluated the demographic, clinical and microbiological profile patients with lower respiratory tract maltophilia.A retrospective analysis 33 diagnosed infections during a period two years from 2012 - 2013 was done.The predominant predisposing factor observed mechanical ventilation in...

Melioidosis has recently gained the status of an emerging disease in India. Multidrug-resistant (MDR) Gram-negative bacteria, however, are already responsible for treatment failure and mortality. In addition, pandrug-resistant (PDR) bacteria have emerged as a new threat to modern medicine. The treatment, clinical follow up, outcome 25 patients with melioidosis 46 MDR non-fermenters (Pseudomonas aeruginosa Acinetobacter spp.) infection were documented during period 2005 2007. Pandrug...

Background: There are reports of emergence resistant strains S. pneumoniae showing resistance to penicillin from all over the world, and now, multiple drugs (multidrug-resistant strains) has been added it. However, scanty available so far India, depicting such resistance. Aims: The aim present study is look for prevalence penicillin-resistant pneumococci also multidrug-resistant among pneumoniae, isolated respiratory specimens, in coastal part South India. Settings Design: A cross-sectional...

A majority of the studies done on western population have shown that Pseudomonas aeruginosa causes many severe infections in patients with bronchiectasis as compared to other pathogens. There is scarcity similar data from Asian population.

Antibodies to Hepatitis B surface Antigen (Anti-HBs) levels are measured as markers for immune response vaccination and in decision making post-exposure prophylaxis against Hepatitis-B. Several immunoassay formats used measure Anti-HBs, thus carrying the possibility of variation between different assays. This study compares performance Chemiluminescence Immunoassay (CLIA) Enzyme-linked Immunosorbent Assay (ELISA) measuring Anti-HBs titer by looking into concordance two test reports.

Background: Aeromonas species are gram-negative rods usually isolated from the gastrointestinal tract. They have been occasionally reported as a cause of extra-intestinal infections such cellulitis, cholangitis, necrotizing fascitis, meningitis, bacteremia, or peritonitis in both immunocompetent and immunocompromised patients . Aim: To determine role possible pathogenesis infections. Settings Design: Retrospective analysis carried out at Kasturba Hospital Manipal, Karnataka months January...

Bronchopleural fistula (BPF) is a communication between the pleural space and bronchial tree.A series of 9 cases are reported where BPF was identified managed with intrabronchial instillation glue (N-butyl-cyanoacrylate) through video bronchoscope.Out patients successfully sealed in 8 (88.88%). In 1 patient postpneumonectomy, big, that >8 mm who had recurrence after procedure. one case pyopneumothorax leak reduced slowly it took us 14 days to remove intercostal drainage tube. Rest favorable...

Nocardiosis is a localized or disseminated infection caused by soil-borne aerobic actinomycetes. Pulmonary nocardiosis rare mostly occurring in immunocompromised patients. We reported case of 36 year old immunocompetent non-smoker female patient with no premorbid illness who presented fever, cough scanty sputum, hemoptysis, left sided chest pain and exertional dyspnea for two weeks. There was past history tuberculosis, diabetes mellitus steroid therapy. Chest X-ray showed homogenous...

The delayed identification and management of musculoskeletal tuberculosis (MSTB) poses substantial health challenges leads to significant morbidity. This study aimed collate ten years hospital data provide valuable insights into the clinical, diagnostics, outcomes patients diagnosed with MSTB.