A5028813127- Cancer Genomics and Diagnostics
- Mathematical Biology Tumor Growth
- Prostate Cancer Treatment and Research
- Evolution and Genetic Dynamics
- Glioma Diagnosis and Treatment
- Computational Drug Discovery Methods
- COVID-19 and healthcare impacts
- Innovative Microfluidic and Catalytic Techniques Innovation
- Climate Change and Health Impacts
- Infection Control and Ventilation
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Adrenal and Paraganglionic Tumors
- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Advanced Breast Cancer Therapies
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Radiation Dose and Imaging
- Vascular Tumors and Angiosarcomas
Cleveland Clinic
2020-2024
Cleveland Clinic Lerner College of Medicine
2020-2021
University School
2020-2021
Case Western Reserve University
2020-2021
Moffitt Cancer Center
2019
University of Washington
2019
Integration of evolutionary dynamics into systemic therapy for metastatic cancers can prolong tumor control compared with standard maximum tolerated dose (MTD) strategies. Prior investigations have focused on monotherapy, but many clinical cancer treatments combine two or more drugs. Optimizing the in multidrug is challenging because complex cellular interactions and large parameter space potential variations drugs, doses, treatment schedules. However, also represents an opportunity to...
Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in event an infectious pandemic. As incidence Coronavirus Disease 2019 (COVID-19) increases exponentially United States many parts world, healthcare provider demand for these necessities currently outpacing supply. In midst current pandemic, there has been a concerted effort identify viable ways conserve PPE, including decontamination after use. this study, we outline...
In this study, we experimentally measure the frequency-dependent interactions between a gefitinib-resistant non–small cell lung cancer population and its sensitive ancestor via evolutionary game assay. We show that cost of resistance is insufficient to accurately predict competitive exclusion growth rate measurements are required. Using data, then gefitinib treatment results in ancestor, while absence likely, but not guaranteed, resistant strain. Then, using simulations, demonstrate...
ABSTRACT DISCLAIMER This article does not represent the official recommendation of Cleveland Clinic or Case Western Reserve University School Medicine, nor has it yet been peer reviewed. We are releasing early, pre-peer review, to allow for quick dissemination/vetting by scientific/clinical community given necessity rapid conservation personal protective equipment (PPE) during this dire global situation. welcome feedback from community. Personal (PPE), including face shields, surgical masks,...
Abstract Integrating mathematical modeling and in vitro experiments to measure ecological interactions cancer Maximilian Strobl, Dagim Tadele, Jeffrey Maltas, Rowan Barker-Clarke, Mina Dinh, Jacob Scott Over the past two decades it has become clear that tumours are complex evolving ecosystems, which different cell populations interact with each other their non-tumour microenvironment. This understanding given rise intriguing idea we might be able leverage these slow, or even revert,...
ABSTRACT Therapeutic strategies for tumor control have traditionally assumed that maximizing reduction in volume correlates with clinical efficacy. Unfortunately, this rapid decrease burden is almost invariably followed by the emergence of therapeutic resistance. Evolutionary based treatment attempt to delay resistance via judicious treatments maintain a significant treatable subpopulation. While these shown promise recent trials, they often rely on biological conjecture and intuition derive...
Alamar Blue (AB) has become an increasingly popular reagent of choice for cell viability assays. We chose AB over other reagents such as MTT and Cell-Titer Glo due to its cost effectiveness ability be a nondestructive assay. While analyzing the effect osimertinib, EGFR inhibitor on non-small lung cancer line, PC-9, we noticed unexpected right-shifts dose response curves compared curve obtained by Cell Titer Here, describe our modified assay method avoid right shift in curve. Unlike some...
Cell-cell fusion has been implicated in various physiological and pathological processes, including cancer progression. This study investigated the role of cell-cell non-small cell lung (NSCLC), focusing on its contribution to chemoresistance tumor evolution. By co-culturing drug-sensitive drug-resistant NSCLC lines, we observed spontaneous events, particularly under gefitinib selection. These fused cells exhibited enhanced fitness a higher degree compared parental lines across panel 12...
<div>AbstractPurpose:<p>Integration of evolutionary dynamics into systemic therapy for metastatic cancers can prolong tumor control compared with standard maximum tolerated dose (MTD) strategies. Prior investigations have focused on monotherapy, but many clinical cancer treatments combine two or more drugs. Optimizing the in multidrug is challenging because complex cellular interactions and large parameter space potential variations drugs, doses, treatment schedules. However,...
<div>AbstractPurpose:<p>Integration of evolutionary dynamics into systemic therapy for metastatic cancers can prolong tumor control compared with standard maximum tolerated dose (MTD) strategies. Prior investigations have focused on monotherapy, but many clinical cancer treatments combine two or more drugs. Optimizing the in multidrug is challenging because complex cellular interactions and large parameter space potential variations drugs, doses, treatment schedules. However,...
<p>Supplementary material</p>
<p>Supplementary material</p>
Abstract Hypoxia and the development of spatially heterogeneous hypoxic and/or necrotic regions in non-small cell lung cancer (NSCLC) other solid tumors is associated with chemotherapy radiation resistance. One mechanism by which this could occur through modification cell-cell interactions (or games) between resistant naïve cells within tumor. Cell-cell can modify fitness thereby change evolutionary dynamics a may, way, game directly support maintenance population cells. To understand...
Abstract OBJECTIVES Medulloblastoma is the most common malignant pediatric brain neoplasm, but its pattern of care among adult patients has not been standardized. Disparity in socioeconomic factors influence treatment decision and prognosis many cancers. This study aims to analyze impact insurance status on clinical outcome with medulloblastoma United States. METHODS Adult (age 18 or older) diagnosed from 2004 2016 were identified National Cancer Database (NCDB). OS was evaluated...