Reactive oxygen species (ROS) are cytotoxic agents that lead to significant oxidative damage. Bisphenol A (BPA) is a contaminant with increasing exposure it and exerts both toxic estrogenic effects on mammalian cells. Due limited information concerning the effect of BPA liver, this study investigates whether causes hepatotoxicity by induction stress in liver. Rats were divided into five groups: The first four groups, (0.1, 1, 10, 50 mg/kg/day) administrated orally rats for weeks. fifth group...

Background: Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed assess mechanism oleuropin-induced breast cell apoptosis. Materials and Methods: p53, Bcl-2 Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) luminal MCF-7 cells. Results:...

The present study centered around the prospect of bio fabricating nanoparticles using Moringa oleifera leaf and investigating their therapeutic potential with an assessment antioxidant status. Synthesis stable 'green' extract is successfully reported extensive characterization. average particle size polydispersity index (PDI) obtained by Dynamic light scattering (DLS) analysis were 141.6 nm a 0.32 respectively. UV–visible spectroscopy (UV–vis) revealed strong red absorbance peak at 664...

Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase (MMP) enzymes facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects. This study aimed investigate effect of oleuropein on metastatic and anti-metastatic gene expression MDA human breast cell line. We evaluated MMPs TIMPs by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) treated untreated cells. demonstrated that OL may...

As the human population continues to escalate, its requirement for clean water is also increasing. This has resulted in an increased dependency on wastewater effluent maintain base flow of urban streams, especially water-stressed regions. The present study reports synthesis AgNPs with green credentials using aqueous extract Trigonella foenum-graecum seeds. observance surface plasmon resonance (SPR) UV–Vis spectrophotometry confirmed presence spherical/oblong particles a mean diameter 43.8 nm...

Abstract The extensive application of polystyrene (PS) in the industry and release microplastics (PS-MPs) environmental compartments has raised global concerns. ability microbes to utilize PS as a carbon source been currently established. This study utilized Bacillus subtilis (ATCC 11774) break down environmentally relevant sized PS-MPs (5 µm) with without abiotic (thermal UV radiations) pretreatment for period 4 weeks. biodegradation rate was validated using UV–visible (UV–Vis) Fourier...

The aquaculture industry is facing a growing need for cost-effective, sustainable, and highly nutritious alternative to fish meal (FM) due the increasing gap between supply demand. This study investigated effect of substituting with probiotics (Spirulina platensis) in feed on survival, growth, biochemical parameters Oreochromis niloticus. Live tilapia fingerlings were stocked 100-l glass aquaria. feeding regimen consisted four controls: commercial (C), formulated FM (FMR0), feeds 25% 50%...

Purpose: To assess whether bisphenol A contamination occurred in seven brands of bottled drinking water Riyadh, Saudi Arabia.Methods: Liquid-liquid extraction (using dichloromethane) was used to analytically extract from bottles and a gas chromatograph-mass spectrometer employed for its detection using splitless capillary column helium as the carrier gas.Results: The concentration (BPA) high all tested. mean BPA stored indoors (4.03 ng/L) significantly lower than that outdoors (7.5...

The current research interest in nanoscience centers around the synthesis of nanoparticle with noble metals due to their distinctive characteristics that has expanded prospective utilization various fields science and technology. study reports green fabrication bimetallic composite nanoparticles (CNPs) silver (Ag) gold(Au) via an eco-friendly mode a biomaterial, orange peel (OP) extract as reductant. reaction aqueous solutions nitrate (AgNO3) chloroauric acid (HAuCl4) OP resulted rapid...

Coming into the second year of pandemic, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants continue to be a serious health hazard globally. A surge in omicron wave, despite discovery vaccines, has shifted attention research towards use bioactive compounds, being potential inhibitors viral structural proteins. The present study aimed at green synthesis zinc oxide (ZnO) nanoparticles with seed extracts Nigella sativa Pimpinella anisum-loaded nanostructured oil carriers...

The present study assessed the ameliorative potential of a commercial probiotic, Protexin® and its nanoformulation against cadmium (Cd) toxicity in Wistar rats. 'green' synthesized nanoparticles had size 170 nm (PDI 0.527) with spherical tubular bacillary shapes. Rats were exposed to 70 ppm chloride hydrate for 35 days. Group I V negative positive control respectively. Groups II, III, IV Cd. Cd groups, III treated probiotic nanoprobiotic (1 ml containing 2 × 108cfu) intoxication led...

Abstract In recent years, green synthesis of nanoparticles has been the cornerstone development nanotechnology and its applications, as it emphasizes on promoting environmental sustainability. The aim present study was to investigate potential health benefits green-synthesized titanium (TiO 2 NPs). TiO NPs were synthesized using titanium( iv ) isopropoxide lupin bean extract. particles characterized assess average particle size by dynamic light scattering, X-ray diffraction method used...

The study was designed to assess the antioxidative potential of three dietary antioxidants, vitamin C, Rosemary (Rosmarinus officinalis) leaf extract (10% carnosic acid) and Amla ( Embilica officinalis ) fruit (aqueous) on cadmium-induced oxidative stress related histopathology liver kidney Wistar rats. Cadmium administered as cadmium chloride (15 mg/kg body weight/day) for 4 weeks with five groups co-treated C (100 mg/kg/day) 30 amla 200 mg/kg/day). results showed that induced a significant...

Bisphenol A(BPA) is a non-persistent, anthropic compound and continues to be ubiquitous in the environment. Since BPA estrogenic nature, its exposure induces adverse cellular responses associated with oxidative stress inflammation. Hesperetin, major flavonoid present lemons sweet oranges exhibits broad spectrum of pharmacological effects attributed potent anti-inflammatory antioxidant status. The current study reports 'green' synthesis nano hesperetin (NHsp) followed by characterization that...

Contamination by fungi and the toxins they secrete is a worldwide health concern. One such toxin zearalenone (Zea), which structurally similar to hormone estrogen, interferes with its action on reproductive system, therefore classified as an endocrine disruptor. This study aims determine effectiveness of hispidin magnesium nanoparticles (MgONPs) against zearalenone-induced myotoxicity, causes polycystic ovary syndrome (PCOS) in rats. A three-month exposure was performed using female Wistar...