A5078381976- Microbial Natural Products and Biosynthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Adsorption and biosorption for pollutant removal
- Bioactive Compounds and Antitumor Agents
- Extraction and Separation Processes
- DNA and Nucleic Acid Chemistry
- Conducting polymers and applications
- Bone Tissue Engineering Materials
- Organic Electronics and Photovoltaics
- Natural product bioactivities and synthesis
- Parasitic Infections and Diagnostics
- Porphyrin and Phthalocyanine Chemistry
- Synthesis of Organic Compounds
- Marine Biology and Environmental Chemistry
- Click Chemistry and Applications
- Marine Sponges and Natural Products
- Marine Ecology and Invasive Species
- Amyotrophic Lateral Sclerosis Research
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- Synthesis and Biological Activity
- Plant Toxicity and Pharmacological Properties
- Analytical Chemistry and Chromatography
- Bacterial biofilms and quorum sensing
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2019-2024
Hong Kong University of Science and Technology
2019-2024
University of Hong Kong
2019-2024
Shenzhen University
2020-2023
Wuhan Institute of Technology
2021
Southern University of Science and Technology
2018-2019
Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They proved to be the leading cause bitterness consumed for therapeutic purposes as food. Numerous studies have focused on intend develop new chemotherapeutic or complementary medicine recent years. showed various bioactivities such anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti-insect, anti-bacteria, antiviral...
The coordination mechanism of neural innate immune responses for axon regeneration is not well understood. Here, we showed that neuronal deletion protein tyrosine phosphatase non-receptor type 2 sustains the IFNγ-STAT1 activity in retinal ganglion cells (RGCs) to promote after injury, independent mTOR or STAT3. DNA-damage-induced cGAMP synthase (cGAS)-stimulator interferon genes (STINGs) activation functional downstream signaling. Directly activating STING by promotes regeneration. In...
The G-quadruplex (G4) forming C9orf72 GGGGCC (G4C2) expanded hexanucleotide repeat (EHR) is the predominant genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Developing selective G4-binding ligands challenging due to conformational polymorphism similarity G4 structures. We identified three first-in-class marine natural products, chrexanthomycin A (cA), B (cB), C (cC), with remarkable bioactivities. Thereinto, cA shows highest permeability lowest...
The crude extract of Streptomyces chrestomyceticus exhibited strong and broad activities against most “ESKAPE pathogens.” We conducted a comprehensive chemical investigation for secondary metabolites from the S. strain identified two novel albofungin ( alb ) derivatives, i.e., albofungins A (1) B (2), along with known compounds, (3) chloroalbofungin (4). structures compounds were elucidated using HRMS, 1D 2D NMR, electronic circular dichroism spectroscopy. draft genome was sequenced, 72 kb...
Marine biofouling caused huge economic losses of maritime industries. We aim to develop high-efficient, less-toxic, and cost-effective antifoulants solve the problems biofouling. In this study, we described antifouling compounds albofungin its derivatives (albofungin A, chrestoxanthone chloroalbofungin) isolated from metabolites bacterium Streptomyces chrestomyceticus BCC 24770, construction high-yield strains for production, application albofungin-based coatings. Results showed that these...
A convergent protecting-group free 10-step total synthesis of anthracimycin and B (first) was achieved, featuring cascade vinylogous Mukaiyama Aldol intramolelucular Diels–Alder reaction Z-selective ring-closing metathesis.
Siladenoserinols A and H were found to show moderate inhibitory activity toward p53-Hdm2 interactions. Our total synthesis allowed us further examine their bioactivities, which revealed that (i) siladenoserinols not cytotoxic against cancer cell lines (ii) siladenoserinol its desulfamate analogue exhibited significant antibacterial Gram-positive bacteria including MRSA. studies demonstrate are a promising new class of bactericidal antibiotics without hemolytic activity.
The genus Pteris (Pteridaceae) has been used as a traditional herb for long time. In particular, laeta Wall. ex Ettingsh. widely in Chinese medicine to treat nervous system diseases and some pterosin sesquiterpenes from show neuroprotective activity, but their underlying molecular mechanisms remain elusive. Therefore, investigate the activity working mechanism of P. will provide better understanding guidance using medicine.We aim develop effective treatments neurodegenerative by evaluating...
Chronic pain management poses a formidable challenge to healthcare, exacerbated by current analgesic options' limitations and adverse effects. Transient receptor potential vanilloid 1 (TRPV1), non-selective cation channel, has emerged as promising target for novel analgesics. However, safety tolerability concerns have constrained the development of TRPV1 modulators. In this study, we explored marine-derived natural products source modulators using high-throughput dye-uptake assays. We...
The potent antibiotics albofungin [systematic name: (1 S ,4 R ,8a )-13-amino-1,15,16-trihydroxy-4-methoxy-12-methyl-3,4,8a,13-tetrahydro-1 H -xantheno[4′,3′,2′:4,5][1,3]benzodioxino[7,6- g ]isoquinoline-14,17(2 ,9 )-dione, C 27 24 N 2 O 9 , 1 ] and its chlorinated analogue chloroalbofungin (the 11-chloro analogue, 23 ClN ) have been crystallized following their isolation from the bacterial strain Streptomyces chrestomyceticus structures determined by single-crystal X-ray diffraction. novel...
Albofungin is a promising broad-spectrum antimicrobial compound against multidrug-resistant bacteria. In the present study, we further investigated albofungin's biofilm eradication activity and its potential mode of action drug-resistant Vibrio parahaemolyticus. Among all derivatives, albofungin exhibited best antibiofilm antibacterial with rapid killing effects at 0.12 µg mL-1. Confocal microscopy observation that disrupted V. parahaemolyticus biofilms by or dispersing cells. Meanwhile,...
Abstract As an eco-friendly adsorption material, hydroxyapatite (Ha) have received widely attention from researchers owing to their excellent biocompatibility and performance. However, the inconvenient in separating Ha powder adsorbed processes following use has limited application. Herein, a novel alginate-based composite beads encapsulation with cellulose (named HCA) was designed remove Cu(II) aqueous solution. Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD),...
Antibiotic albofungin and its chlorinated analogue chloroalbufungin were identified from Streptomyces chrestomyceticu BCC 24770.[1] With the determination by XRD, they have different 3D crystal structures but similar 2D packings (albofungin has a monoclinic P21 structure with Z = 2, while chloroalbufingin is C2 4).[1] The overlay of shown below.Applying Supramolecular Construct (SC), which Gelbrich Hursthouse first presented in 2005, fundamental approach for determining degree...