A5008190677- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Gut microbiota and health
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- GDF15 and Related Biomarkers
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition and Health in Aging
- Macrophage Migration Inhibitory Factor
- Tea Polyphenols and Effects
- Muscle metabolism and nutrition
- Herbal Medicine Research Studies
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Neurogenesis and neuroplasticity mechanisms
- Sirtuins and Resveratrol in Medicine
University of Memphis
2017-2025
Ospedale SS. Annunziata
2023
North Carolina Agricultural and Technical State University
2019
United States Department of Homeland Security
2019
Skidmore College
2019
University of Illinois Chicago
2019
University of Illinois Urbana-Champaign
2009-2018
University of Illinois System
2015
Mayo Clinic
2015
WinnMed
2015
The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. Hippocampal medial temporal lobe volumes are larger higher-fit adults, physical activity training increases hippocampal perfusion, but the extent which aerobic exercise can modify volume adulthood remains unknown. Here we show, a randomized controlled trial with 120 older that size of anterior hippocampus, improvements spatial memory. Exercise by 2%, effectively reversing age-related loss 1...
Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger hippocampal decay aging humans remains a matter of speculation. In rodents, brain-derived neurotrophic factor (BDNF) promotes growth and proliferation cells hippocampus is important long-term potentiation memory formation. humans, circulating levels BDNF decline with advancing age, genetic polymorphism for has been related to gray loss old age. this study, we tested whether age-related reductions serum...
Abstract Exercise training or higher levels of physical activity are known to exert anti-inflammatory effects. CD14+CD16+ monocytes potent producers inflammatory proteins, and elevated these “inflammatory” have been implicated in disease development. Little is about the influence exercise on this cell population. On basis their pattern, male female subjects, 65–80 years old, were assigned a physically active (PA; n=15) inactive (PI; group. The PI group performed 12 weeks (3 days/week)...
Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which preserve executive is through the up-regulation of brain-derived neurotropic factor (BDNF), also age. The present study examined BDNF as a mediator effects 1-year walking intervention on 90 older adults (mean age = 66.82). Participants were randomized to stretching and toning control group or moderate intensity group. serum levels performance task-switching paradigm collected...
We have previously shown that voluntary wheel running (VWR) attenuates, whereas forced treadmill (FTR) exacerbates, intestinal inflammation and clinical outcomes in a mouse model of colitis. As the gut microbiome is implicated colitis, we hypothesized VWR FTR would differentially affect microbiome. Mice (9-10/treatment) were randomly assigned to VWR, FTR, or sedentary home cage control (SED) for 6 wk. given access, ran on 40 min/day at 8-12 m/min, 5% grade. Forty-eight hours after last...
Aging is a critical healthcare concern, with age-related inflammation disposing individuals to variety of diseases. Monocytes are affected by the aging process, increased and impaired cellular functions such as phagocytosis. Mechanisms which alters monocyte function unknown, but recent research suggests that balance metabolic processes determine immune cell phenotype function. Given known association between mitochondrial dysfunction in other tissues, we hypothesized would impair monocytes....
The purpose of this study was to observe exercise training–induced effects on adiponectin, leptin, and ghrelin. Twenty-nine older, healthy participants were classified as physically active (comparison group: N = 15, 70.9±1.2 years) or inactive (exercise 14, 70.5±1.4 years). Exercise group completed 12 weeks combined aerobic resistance training, whereas comparison maintained their current level served a group. Monocyte phenotype, well serum ghrelin, soluble tumor necrosis factor receptor II...
Abstract Aging is a complex process that involves dysfunction on multiple levels, all of which seem to converge inflammation. Macrophages are intimately involved in initiating and resolving inflammation, their dysregulation with age primary contributor inflammaging—a state chronic, low-grade inflammation develops during aging. Among the age-related changes occur macrophages heightened basal diminished or hyperactive inflammatory responses, be driven by metabolic-dependent epigenetic changes....
Inflammaging is a condition of chronic low-grade inflammation due to the aging process and associated with variety diseases. Monocytes are innate immune cells which contribute dysregulated during aging, demonstrated reduced phagocytosis, increased inflammation, alterations in subset proportions. Metabolism known determine cell function, quiescent anti-inflammatory primarily relying on fatty acid oxidation, while activated inflammatory rely glycolysis. We have previously shown an age-related...
A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes undergo metabolic reprogramming and produce inflammatory cytokines when stimulated SARS-CoV-2. We hypothesized that binding by the viral spike protein mediates this effect, drugs which regulate immunometabolism could inhibit response. recombinant SARS-CoV-2 subunit 1 showed dose-dependent increase in glycolytic metabolism production pro-inflammatory cytokines. This response was dependent on...