Introduction: Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomal recessive inherited disorder characterized by intermittent jaundice episodes. Case Presentation: We report 25-year-old male patient with numerous hospitalizations for jaundice. The diagnosis of BRIC type 1 was established liver biopsy, genetic analysis, and the exclusion alternative etiologies cholestasis. A novel missense heterozygous variant identified in ATP8B1 gene (c.2081T>A). acute cholestatic attack,...

Background: Anaplastic lymphoma kinase (ALK) mutations have been identified as a prominent cause of some familial and sporadic neuroblastoma (NB). ALK expression in NB its relationship with clinical histopathological features remains controversial. This study investigated potential relations these NB.Methods: Ninety cases at the Department Pathology, University Medicine Pharmacy Ho Chi Minh City, Viet Nam from 01/01/2018 to 12/31/2021, were immunohistochemically stained (D5F3) antibody. The...

Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy trastuzumab.We investigated 208 specimens using immunohistochemistry (IHC), fluorescence in situ hybridization dual (ISH). We also concordance between IHC ISH. The correlation status various clinicopathological findings was investigated.In...

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Background: The identification of idiopathic inflammatory myopathies (IIMs) requires a comprehensive analysis involving clinical manifestations and histological findings. This study aims to provide insights into the histopathological immunohistochemical aspects IIMs. Methods: retrospective case series involved 56 patients diagnosed with IIMs at Department Pathology, University Medicine Pharmacy Ho Chi Minh City, from 2019 2023. histology expression HLA-ABC, HLA-DR, C5b-9, Mx1/2/3, p62 were...

Introduction and Aims: Immune mediated necrotizing myopathy (IMNM) is a sub-type of inflammatory myopathies (IIM) that presents with significant muscle weakness, elevated creatine kinase (CK) levels histopathological features fiber necrosis, without myositis specific antibodies. The aims this study was to clarify clinical characteristics autoimmune antibodies (Ab) patients immune-mediated in Vietnamese patients. Methods: A retrospective, single centre, case-series, describing the...

IntroductionVE1 is a monoclonal antibody detecting mutant BRAF V600E protein by immunohistochemistry (IHC) with high concordance rate molecular analysis in many cancers. Materials and methods: mutation was assessed on 94 pediatric LCH patients using sequencing VE1 stringent lenient-scoring criteria. Results: exon 15 detected 47.9% of cases. multiple-system 65.2%, significantly higher than single-system (p = .001). assays showed 35.6% sensitivity, 75.5% specificity (Stringent criteria), 91.1%...

Introduction: Pigmented epithelioid angiomyolipoma is a variant of (EAML) that has not previously been described in children with tuberous sclerosis.Case presentation: A 15-year-old boy sclerosis had rapidly enlarging renal mass associated left lung nodule. Microscopically it was pigmented EAML, confirmed by immunohistochemistry.Discussion/Conclusion: The EAML can arise and metastasize from the kidney teenager sclerosis.

Introduction: Pediatric DLBCL is considered a homogenous group and has superior outcomes compared to adults. This study investigated the clinical pathology immunohistochemical distinction between adult pediatric large B-cell lymphoma. Methods: A cross-sectional of 314 NHLs with morphology diffuse pattern, B-cell, CD20 expression was investigated. Results: Of cases, there were 6 cases pleomorphic MCL (all in adults), 19 Burkitt lymphoma children), 289 DLBCL. had many striking differences:...

Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of gastrointestinal tract. Management GIST patients is currently based on clinicopathological features and associated genetic changes. However, detailed characteristics molecular GISTs have not yet been described in Vietnamese population.We first identified 155 with primary who underwent surgery curative intent between 2011 2014 at University Medical Center Ho Chi Minh City, Vietnam. We evaluated...

Background Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation associated with recurrent high-risk LCH. Methods We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF_V600E by sequencing. The relationship between status clinicopathological parameters were also critically analyzed. Results exon 15 was detected 45 cases (47.9%). Multiple systems showed a significantly higher rate single...

Abstract Background: Several lines of evidence have been focused on the roles tryptophan metabolism genes like indoleamine 2,3-dioxygenase 1 (IDO1) and (TDO2) in bladder cancer progression. However, alternative way targeting immunotherapy has not yet investigated cancer. Method: We explored validated clinicopathological significance correlation with immune infiltrates IDO1 TDO2 expression using Bladder urothelial carcinoma (BLCA) other Gene Expression Omnibus (GEO) datasets (GSE13570,...

Lymphoma-associated hemophagocytic syndrome is a life-threatening disease with poor prognosis and may present as ischemic stroke. We report case of 56-year-old female recurrent multi-territory infarcts caused by diffuse large B-cell lymphoma secondary lymphohistiocytosis. She had been diagnosed stroke probably to Epstein-Barr virus infection 3 months previously treated Dexamethasone Aspirin. High resolution vessel wall magnetic resonance imaging showed thickening at some intracranial vessels...

A 54-year-old female patient was hospitalized due to breathlessness.Her past history includes childhood asthma requiring Ventolin as needed.Since 1 year, she has suffered from severe weight gain, worsening snoring associated with repeated sleep apnoea, early morning headache, daytime sleepiness, persistent breathlessness at walking about 10m, taking shower or changing clothes.No wheezing, chest tightness, nocturnal is noticed.The frequently used relievers and been thrice in the last year...

A 54-year-old female patient was hospitalized due to breathlessness.Her past history includes childhood asthma requiring Ventolin as needed.Since 1 year, she has suffered from severe weight gain, worsening snoring associated with repeated sleep apnoea, early morning headache, daytime sleepiness, persistent breathlessness at walking about 10m, taking shower or changing clothes.No wheezing, chest tightness, nocturnal is noticed.The frequently used relievers and been thrice in the last year...

A 54-year-old female patient was hospitalized due to breathlessness.Her past history includes childhood asthma requiring Ventolin as needed.Since 1 year, she has suffered from severe weight gain, worsening snoring associated with repeated sleep apnoea, early morning headache, daytime sleepiness, persistent breathlessness at walking about 10m, taking shower or changing clothes.No wheezing, chest tightness, nocturnal is noticed.The frequently used relievers and been thrice in the last year...